Reviewed, UniProtKB/Swiss-Prot A0K2D5 (AROE_ARTS2)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Arth_4080

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325100
Regions
	Nucleotide binding	136 – 140	5	NADP By similarity
Sites
	Active site	76	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A0K2D5-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: FC2EB3DDC4789AC3	FASTA	293	31,189
	10 20 30 40 50 60 MSNRAESFLV GLVGDGVMPS LTPHMHEREG DVQGLRYLYR PIDLLELGLP GESVGELLQS 70 80 90 100 110 120 AHRMGFNGLN ITHPCKQLVL DHLDEIAPDA RRLGAVNTVI IRDGRFTGHN TDFSGFAAAL 130 140 150 160 170 180 ASGLPDAKLD RVVQLGAGGA GSAVAYALLT AGVRHLDLVD TDAARCAERA AELAGFFPDS 190 200 210 220 230 240 SVTARTTAEL PQLMPLADGL VHCTPVGMAA HPGAPLDLSL LESRHWVADI VYRPIDTELV 250 260 270 280 290 REARAKGCEV LDGGRMAVGQ AADAFRIFTG LEADADRMRA HFLELVAAEE VTA

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK05455.1.
RefSeq	YP_833555.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4447722.
GenomeReviews	Gene locus Arth_4080 in contig CP000454_GR.
KEGG	art:Arth_4080.
TIGR	Arth_4080.
Phylogenomic databases
OMA	A0K2D5. VKAFELF.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROE_ARTS2

Accession

Primary (citable) accession number: A0K2D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)