Reviewed, UniProtKB/Swiss-Prot A0K258 (MTLD_ARTS2)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	Arth_4003

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011793
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0K258-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 77C999E600295831	FASTA	384	40,805
	10 20 30 40 50 60 MKAVHFGAGN IGRGFVGLLL HQAGYELVFA DVAEELISQL AAADSYDVHE VGDNPTVRTV 70 80 90 100 110 120 DNFRALNSAT QEADVVAEIA TADVVTTAVG PHILKFVAPV IAKGIAARAA GLAPLQVMAC 130 140 150 160 170 180 ENAINATDIL RDEVAAQWDP AAGPLEAVAV FANTAVDRIV PNQEPGKGLD VTVETFYEWV 190 200 210 220 230 240 IDRTPFGDNV PVIPGATFVD NLEPYIERKL FTVNTGHAAA AYFGFEAGLS KISEAMADQD 250 260 270 280 290 300 VAADVRAVLD ETKELLIHKH GFNREEQEAY VEKILGRFTN PHLPDTVNRV GRAPLRKLSR 310 320 330 340 350 360 HERFIGPAAE LAERGIVPEA LLGAIAAALR FNDPADAEAA ELAQIVASST AAEATEKVTG 370 380 LTPGHPLFAA VEALVEEVKA EVKA

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK05378.1.
RefSeq	YP_833478.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0K258.
Genome annotation databases
GeneID	4447266.
GenomeReviews	Gene locus Arth_4003 in contig CP000454_GR.
KEGG	art:Arth_4003.
TIGR	Arth_4003.
Phylogenomic databases
OMA	VDRIVPN.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ARTS2

Accession

Primary (citable) accession number: A0K258

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)