ID   TRMB_ARTS2              Reviewed;         319 AA.
AC   A0K1I7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   16-JUN-2009, entry version 16.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase;
DE            EC=2.1.1.33;
DE   AltName: Full=tRNA(m7G46)-methyltransferase;
GN   Name=trmB; OrderedLocusNames=Arth_3782;
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K.,
RA   Nakatsu C.H., Richardson P.;
RT   "Complete sequence of chromosome 1 of Arthrobacter sp. FB24.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of N(7)-methylguanine at
CC       position 46 (m7G46) in tRNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(7)-methylguanine.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. TrmB
CC       family.
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DR   EMBL; CP000454; ABK05157.1; -; Genomic_DNA.
DR   RefSeq; YP_833257.1; -.
DR   GeneID; 4447832; -.
DR   GenomeReviews; CP000454_GR; Arth_3782.
DR   KEGG; art:Arth_3782; -.
DR   TIGR; Arth_3782; -.
DR   OMA; A0K1I7; WVFFPDP.
DR   GO; GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_01057; -; 1.
DR   InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase.
DR   PANTHER; PTHR23417:SF1; Methyltransf_4; 1.
DR   Pfam; PF02390; Methyltransf_4; 1.
DR   TIGRFAMs; TIGR00091; CHP91; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN         1    319       tRNA (guanine-N(7)-)-methyltransferase.
FT                                /FTId=PRO_0000288119.
FT   REGION      298    301       Substrate binding (Potential).
FT   BINDING     103    103       S-adenosyl-L-methionine (By similarity).
FT   BINDING     128    128       S-adenosyl-L-methionine (By similarity).
FT   BINDING     155    155       S-adenosyl-L-methionine (By similarity).
FT   BINDING     178    178       S-adenosyl-L-methionine (By similarity).
FT   BINDING     182    182       Substrate (By similarity).
FT   BINDING     214    214       Substrate (Potential).
SQ   SEQUENCE   319 AA;  34907 MW;  66612CE2339DD1A6 CRC64;
     MSESPETPEP SPAQSPEAAP EQPQAARPVT PGSQASFGTY GGRPVSFVRR GTRLQGRRQQ
     AWEEHSDRWA VDVPRHIANT SVHPDYVFDA EAEFGRSAPL IVEIGSGLGD AVCHAAEENP
     DWDFLAVEVY TPGLANTVIK INSRKLSNVR VVEANAPEVL ATMLPAGSVS EVWVFFPDPW
     HKSRHHKRRL IQPEFAALVA AALKPGGLFR VATDWSNYAV HVRDVMAGSA DFVNLHDGER
     RGPESPLTQV WQSGVESLVG GAPVKEGRAP VSTEHTGPNE GVDETGGWAP RFEGRIRTSF
     ENKAHEAGRL IFDLCYRRL
//