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A0K1I7

- TRMB_ARTS2

UniProt

A0K1I7 - TRMB_ARTS2

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
Binding sitei128 – 1281S-adenosyl-L-methionineUniRule annotation
Binding sitei155 – 1551S-adenosyl-L-methionineUniRule annotation
Active sitei178 – 1781By similarity
Binding sitei178 – 1781S-adenosyl-L-methionineUniRule annotation
Binding sitei182 – 1821SubstrateUniRule annotation
Binding sitei214 – 2141SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciASP290399:GHIF-3857-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Arth_3782
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319tRNA (guanine-N(7)-)-methyltransferasePRO_0000288119Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290399.Arth_3782.

Structurei

3D structure databases

ProteinModelPortaliA0K1I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni298 – 3014Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiGWAPRFE.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0K1I7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESPETPEP SPAQSPEAAP EQPQAARPVT PGSQASFGTY GGRPVSFVRR
60 70 80 90 100
GTRLQGRRQQ AWEEHSDRWA VDVPRHIANT SVHPDYVFDA EAEFGRSAPL
110 120 130 140 150
IVEIGSGLGD AVCHAAEENP DWDFLAVEVY TPGLANTVIK INSRKLSNVR
160 170 180 190 200
VVEANAPEVL ATMLPAGSVS EVWVFFPDPW HKSRHHKRRL IQPEFAALVA
210 220 230 240 250
AALKPGGLFR VATDWSNYAV HVRDVMAGSA DFVNLHDGER RGPESPLTQV
260 270 280 290 300
WQSGVESLVG GAPVKEGRAP VSTEHTGPNE GVDETGGWAP RFEGRIRTSF
310
ENKAHEAGRL IFDLCYRRL
Length:319
Mass (Da):34,907
Last modified:December 12, 2006 - v1
Checksum:i66612CE2339DD1A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK05157.1.
RefSeqiWP_011693607.1. NC_008541.1.
YP_833257.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK05157; ABK05157; Arth_3782.
GeneIDi4447832.
KEGGiart:Arth_3782.
PATRICi21003065. VBIArtSp72239_4210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK05157.1 .
RefSeqi WP_011693607.1. NC_008541.1.
YP_833257.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0K1I7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_3782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK05157 ; ABK05157 ; Arth_3782 .
GeneIDi 4447832.
KEGGi art:Arth_3782.
PATRICi 21003065. VBIArtSp72239_4210.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi GWAPRFE.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci ASP290399:GHIF-3857-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiTRMB_ARTS2
AccessioniPrimary (citable) accession number: A0K1I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3