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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103S-adenosyl-L-methionineUniRule annotation1
Binding sitei128S-adenosyl-L-methionineUniRule annotation1
Binding sitei155S-adenosyl-L-methionineUniRule annotation1
Active sitei178By similarity1
Binding sitei178S-adenosyl-L-methionineUniRule annotation1
Binding sitei182SubstrateUniRule annotation1
Binding sitei214SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Arth_3782
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000000754 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881191 – 319tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST319

Interactioni

Protein-protein interaction databases

STRINGi290399.Arth_3782

Structurei

3D structure databases

ProteinModelPortaliA0K1I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 301Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

A0K1I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESPETPEP SPAQSPEAAP EQPQAARPVT PGSQASFGTY GGRPVSFVRR
60 70 80 90 100
GTRLQGRRQQ AWEEHSDRWA VDVPRHIANT SVHPDYVFDA EAEFGRSAPL
110 120 130 140 150
IVEIGSGLGD AVCHAAEENP DWDFLAVEVY TPGLANTVIK INSRKLSNVR
160 170 180 190 200
VVEANAPEVL ATMLPAGSVS EVWVFFPDPW HKSRHHKRRL IQPEFAALVA
210 220 230 240 250
AALKPGGLFR VATDWSNYAV HVRDVMAGSA DFVNLHDGER RGPESPLTQV
260 270 280 290 300
WQSGVESLVG GAPVKEGRAP VSTEHTGPNE GVDETGGWAP RFEGRIRTSF
310
ENKAHEAGRL IFDLCYRRL
Length:319
Mass (Da):34,907
Last modified:December 12, 2006 - v1
Checksum:i66612CE2339DD1A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA Translation: ABK05157.1
RefSeqiWP_011693607.1, NC_008541.1

Genome annotation databases

EnsemblBacteriaiABK05157; ABK05157; Arth_3782
KEGGiart:Arth_3782

Similar proteinsi

Entry informationi

Entry nameiTRMB_ARTS2
AccessioniPrimary (citable) accession number: A0K1I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health