ID   TYSY_ARTS2              Reviewed;         267 AA.
AC   A0JZC7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Thymidylate synthase;
DE            Short=TS;
DE            Short=TSase;
DE            EC=2.1.1.45;
GN   Name=thyA; OrderedLocusNames=Arth_3018;
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K.,
RA   Nakatsu C.H., Richardson P.;
RT   "Complete sequence of chromosome 1 of Arthrobacter sp. FB24.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Provides the sole de novo source of dTMP for DNA
CC       biosynthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-
CC       type thyA subfamily.
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DR   EMBL; CP000454; ABK04397.1; -; Genomic_DNA.
DR   RefSeq; YP_832497.1; -.
DR   GeneID; 4444385; -.
DR   GenomeReviews; CP000454_GR; Arth_3018.
DR   KEGG; art:Arth_3018; -.
DR   TIGR; Arth_3018; -.
DR   OMA; A0JZC7; LGPVYGH.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:HAMAP.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00008; -; 1.
DR   InterPro; IPR000398; Thymidylat_synth_C.
DR   Gene3D; G3DSA:3.30.572.10; Thymidylat_synth_C; 1.
DR   PANTHER; PTHR11549:SF2; Thymidylat_synth_C; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   ProDom; PD001180; Thymidylat_synth; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   Nucleotide biosynthesis; Transferase.
FT   CHAIN         1    267       Thymidylate synthase.
FT                                /FTId=PRO_0000321466.
FT   ACT_SITE    149    149       By similarity.
SQ   SEQUENCE   267 AA;  30447 MW;  64DE7A588619AC66 CRC64;
     MSIPTPYEDL LRDVLANGTH KSDRTGTGTL SVFGRQMRFD LSQSFPLITT KRVHFKSVAV
     ELLWFLRGET NVKWMQDQGV TIWNEWADAD GELGPVYGVQ WRSWPTPDGG HIDQIAELVE
     NLKSNPDSRR HIVSAWNVAE LQDMALPPCH AFFQFYVADG KLSCQLYQRS ADTFLGVPFN
     IASYALLTCM LAQQVGLEPG EFVWTGGDVH IYDNHMDQVL KQLKREPYEY PQLKILRKPD
     SIFDYTLDDF EVVGYQHHPT IKAPIAV
//