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A0JZC7

- TYSY_ARTS2

UniProt

A0JZC7 - TYSY_ARTS2

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Protein

Thymidylate synthase

Gene

thyA

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciASP290399:GHIF-3086-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:Arth_3018
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Thymidylate synthasePRO_0000321466Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_3018.

Structurei

3D structure databases

ProteinModelPortaliA0JZC7.
SMRiA0JZC7. Positions 7-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiFGRQIRY.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JZC7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIPTPYEDL LRDVLANGTH KSDRTGTGTL SVFGRQMRFD LSQSFPLITT
60 70 80 90 100
KRVHFKSVAV ELLWFLRGET NVKWMQDQGV TIWNEWADAD GELGPVYGVQ
110 120 130 140 150
WRSWPTPDGG HIDQIAELVE NLKSNPDSRR HIVSAWNVAE LQDMALPPCH
160 170 180 190 200
AFFQFYVADG KLSCQLYQRS ADTFLGVPFN IASYALLTCM LAQQVGLEPG
210 220 230 240 250
EFVWTGGDVH IYDNHMDQVL KQLKREPYEY PQLKILRKPD SIFDYTLDDF
260
EVVGYQHHPT IKAPIAV
Length:267
Mass (Da):30,447
Last modified:December 12, 2006 - v1
Checksum:i64DE7A588619AC66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK04397.1.
RefSeqiWP_011692849.1. NC_008541.1.
YP_832497.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK04397; ABK04397; Arth_3018.
GeneIDi4444385.
KEGGiart:Arth_3018.
PATRICi21001461. VBIArtSp72239_3412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK04397.1 .
RefSeqi WP_011692849.1. NC_008541.1.
YP_832497.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0JZC7.
SMRi A0JZC7. Positions 7-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_3018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK04397 ; ABK04397 ; Arth_3018 .
GeneIDi 4444385.
KEGGi art:Arth_3018.
PATRICi 21001461. VBIArtSp72239_3412.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi FGRQIRY.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci ASP290399:GHIF-3086-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiTYSY_ARTS2
AccessioniPrimary (citable) accession number: A0JZC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3