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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei200DesacetylmycothiolUniRule annotation1
Binding sitei240DesacetylmycothiolUniRule annotation1
Binding sitei253DesacetylmycothiolUniRule annotation1
Binding sitei291Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Arth_3013
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000000754 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002401 – 323Mycothiol acetyltransferaseAdd BLAST323

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_3013.

Structurei

3D structure databases

ProteinModelPortaliA0JZC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 323N-acetyltransferaseUniRule annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 100Acetyl-CoA binding 1UniRule annotation3
Regioni257 – 259Acetyl-CoA binding 2UniRule annotation3
Regioni264 – 270Acetyl-CoA binding 2UniRule annotation7

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 1 N-acetyltransferase domain.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JZC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAHPENWP VLVVKGGVDD ELLRDFTALA AAAEESDGNP PLSEQTFVTL
60 70 80 90 100
RAGESGTHSL LSLALYAPDE ESDPATAQDL AGFAVVVEEA DGTGVLELAV
110 120 130 140 150
HPSYRNQGVA DRLVATLKAS RGFDGLKAWS HGNHEAAADL AAKYGYAPIR
160 170 180 190 200
ELWKMRLTAS DAELPDAALP DNVSLRAFIP GQDEEAWLAA NKAAFSHHPE
210 220 230 240 250
QGNMTRQDLA ARMAEDWFDP AGFLLAVDPS GRILGFHWTK VHPGHGGHPA
260 270 280 290 300
IGEVYVVGVT PEAQGMGLGK ALTVAGIKYL QDKGLHAVVL YTDADNTPAV
310 320
SLYRRLGFTR WDADVMYGPK NGG
Length:323
Mass (Da):34,483
Last modified:December 12, 2006 - v1
Checksum:iD6BBD9B02432394B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK04392.1.
RefSeqiWP_011692844.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK04392; ABK04392; Arth_3013.
KEGGiart:Arth_3013.
PATRICi21001451. VBIArtSp72239_3407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK04392.1.
RefSeqiWP_011692844.1. NC_008541.1.

3D structure databases

ProteinModelPortaliA0JZC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290399.Arth_3013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK04392; ABK04392; Arth_3013.
KEGGiart:Arth_3013.
PATRICi21001451. VBIArtSp72239_3407.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_ARTS2
AccessioniPrimary (citable) accession number: A0JZC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.