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A0JZ10

- FTHS_ARTS2

UniProt

A0JZ10 - FTHS_ARTS2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP290399:GHIF-2968-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Arth_2901
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Formate--tetrahydrofolate ligasePRO_0000293032Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290399.Arth_2901.

Structurei

3D structure databases

ProteinModelPortaliA0JZ10.
SMRiA0JZ10. Positions 9-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JZ10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDNNVMSDL EIAQRATMRP IGDIAAAAGI NADAVELYGR YKAKIDPAKL
60 70 80 90 100
IDPAGAPKRL PGKVVLVSAM SPTPAGEGKS TTTVGLADSL ARAGRNVMIA
110 120 130 140 150
LREPSLGPVL GMKGGATGGG YSQVLPMEEI NLHFTGDFHA ITSANNALMA
160 170 180 190 200
LVDNHIFQGN ELNIDPRRMT FKRVLDMNDR SLREVIIGLG GPAQGVPRQD
210 220 230 240 250
GFDITVASEI MAVFCLATDI ADLRARLGRI TFGYTYDREP VTVADLGVQG
260 270 280 290 300
ALTMLLRDAI KPNLVQTIAG TPALVHGGPF ANIAHGCNSL IATQTARRLA
310 320 330 340 350
DIVVTEAGFG ADLGAEKFMD IKARVAGVAP SAVVLVATVR ALKMHGGVAK
360 370 380 390 400
DRLQEPNVEA LAAGSANLRR HIRNVEKFGI TPVVAVNKFA TDTPEELDWL
410 420 430 440 450
LEWCAGEGVQ AAVADVWGRG GGGDGGDELA AKVLAALEAP HSFRHLYPLE
460 470 480 490 500
LSVEDKIRTI VQEMYGADGV DFSVPALKRL AEIEKNGWAG MPVCMAKTQY
510 520 530 540 550
SFSDDATRLG APKGFTVHVR DLIPKTGAGF IVALTGAVMT MPGLPKVPAA
560
LRMDVDDTGK PLGLF
Length:565
Mass (Da):59,652
Last modified:December 12, 2006 - v1
Checksum:i2534351725288ABE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK04280.1.
RefSeqiWP_011692739.1. NC_008541.1.
YP_832380.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK04280; ABK04280; Arth_2901.
GeneIDi4444423.
KEGGiart:Arth_2901.
PATRICi21001213. VBIArtSp72239_3289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK04280.1 .
RefSeqi WP_011692739.1. NC_008541.1.
YP_832380.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0JZ10.
SMRi A0JZ10. Positions 9-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_2901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK04280 ; ABK04280 ; Arth_2901 .
GeneIDi 4444423.
KEGGi art:Arth_2901.
PATRICi 21001213. VBIArtSp72239_3289.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ASP290399:GHIF-2968-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiFTHS_ARTS2
AccessioniPrimary (citable) accession number: A0JZ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3