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A0JZ10

- FTHS_ARTS2

UniProt

A0JZ10 - FTHS_ARTS2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 808ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASP290399:GHIF-2968-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Arth_2901
    OrganismiArthrobacter sp. (strain FB24)
    Taxonomic identifieri290399 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000754: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Formate--tetrahydrofolate ligasePRO_0000293032Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290399.Arth_2901.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JZ10.
    SMRiA0JZ10. Positions 9-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiTWRRCLD.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JZ10-1 [UniParc]FASTAAdd to Basket

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    MSDNNVMSDL EIAQRATMRP IGDIAAAAGI NADAVELYGR YKAKIDPAKL    50
    IDPAGAPKRL PGKVVLVSAM SPTPAGEGKS TTTVGLADSL ARAGRNVMIA 100
    LREPSLGPVL GMKGGATGGG YSQVLPMEEI NLHFTGDFHA ITSANNALMA 150
    LVDNHIFQGN ELNIDPRRMT FKRVLDMNDR SLREVIIGLG GPAQGVPRQD 200
    GFDITVASEI MAVFCLATDI ADLRARLGRI TFGYTYDREP VTVADLGVQG 250
    ALTMLLRDAI KPNLVQTIAG TPALVHGGPF ANIAHGCNSL IATQTARRLA 300
    DIVVTEAGFG ADLGAEKFMD IKARVAGVAP SAVVLVATVR ALKMHGGVAK 350
    DRLQEPNVEA LAAGSANLRR HIRNVEKFGI TPVVAVNKFA TDTPEELDWL 400
    LEWCAGEGVQ AAVADVWGRG GGGDGGDELA AKVLAALEAP HSFRHLYPLE 450
    LSVEDKIRTI VQEMYGADGV DFSVPALKRL AEIEKNGWAG MPVCMAKTQY 500
    SFSDDATRLG APKGFTVHVR DLIPKTGAGF IVALTGAVMT MPGLPKVPAA 550
    LRMDVDDTGK PLGLF 565
    Length:565
    Mass (Da):59,652
    Last modified:December 12, 2006 - v1
    Checksum:i2534351725288ABE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK04280.1.
    RefSeqiWP_011692739.1. NC_008541.1.
    YP_832380.1. NC_008541.1.

    Genome annotation databases

    EnsemblBacteriaiABK04280; ABK04280; Arth_2901.
    GeneIDi4444423.
    KEGGiart:Arth_2901.
    PATRICi21001213. VBIArtSp72239_3289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK04280.1 .
    RefSeqi WP_011692739.1. NC_008541.1.
    YP_832380.1. NC_008541.1.

    3D structure databases

    ProteinModelPortali A0JZ10.
    SMRi A0JZ10. Positions 9-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290399.Arth_2901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK04280 ; ABK04280 ; Arth_2901 .
    GeneIDi 4444423.
    KEGGi art:Arth_2901.
    PATRICi 21001213. VBIArtSp72239_3289.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi TWRRCLD.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci ASP290399:GHIF-2968-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FB24.

    Entry informationi

    Entry nameiFTHS_ARTS2
    AccessioniPrimary (citable) accession number: A0JZ10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3