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A0JZ10 (FTHS_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Arth_2901
OrganismArthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]
Taxonomic identifier290399 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293032

Regions

Nucleotide binding73 – 808ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0JZ10 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 2534351725288ABE

FASTA56559,652
        10         20         30         40         50         60 
MSDNNVMSDL EIAQRATMRP IGDIAAAAGI NADAVELYGR YKAKIDPAKL IDPAGAPKRL 

        70         80         90        100        110        120 
PGKVVLVSAM SPTPAGEGKS TTTVGLADSL ARAGRNVMIA LREPSLGPVL GMKGGATGGG 

       130        140        150        160        170        180 
YSQVLPMEEI NLHFTGDFHA ITSANNALMA LVDNHIFQGN ELNIDPRRMT FKRVLDMNDR 

       190        200        210        220        230        240 
SLREVIIGLG GPAQGVPRQD GFDITVASEI MAVFCLATDI ADLRARLGRI TFGYTYDREP 

       250        260        270        280        290        300 
VTVADLGVQG ALTMLLRDAI KPNLVQTIAG TPALVHGGPF ANIAHGCNSL IATQTARRLA 

       310        320        330        340        350        360 
DIVVTEAGFG ADLGAEKFMD IKARVAGVAP SAVVLVATVR ALKMHGGVAK DRLQEPNVEA 

       370        380        390        400        410        420 
LAAGSANLRR HIRNVEKFGI TPVVAVNKFA TDTPEELDWL LEWCAGEGVQ AAVADVWGRG 

       430        440        450        460        470        480 
GGGDGGDELA AKVLAALEAP HSFRHLYPLE LSVEDKIRTI VQEMYGADGV DFSVPALKRL 

       490        500        510        520        530        540 
AEIEKNGWAG MPVCMAKTQY SFSDDATRLG APKGFTVHVR DLIPKTGAGF IVALTGAVMT 

       550        560 
MPGLPKVPAA LRMDVDDTGK PLGLF 

« Hide

References

[1]"Complete sequence of chromosome 1 of Arthrobacter sp. FB24."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FB24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000454 Genomic DNA. Translation: ABK04280.1.
RefSeqYP_832380.1. NC_008541.1.

3D structure databases

ProteinModelPortalA0JZ10.
SMRA0JZ10. Positions 9-563.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290399.Arth_2901.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK04280; ABK04280; Arth_2901.
GeneID4444423.
KEGGart:Arth_2901.
PATRIC21001213. VBIArtSp72239_3289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMATWRRCLD.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycASP290399:GHIF-2968-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ARTS2
AccessionPrimary (citable) accession number: A0JZ10
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways