A0JZ10 (FTHS_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	Arth_2901

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 565	565	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000293032
Regions
	Nucleotide binding	73 – 80	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JZ10 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 2534351725288ABE	FASTA	565	59,652
	10 20 30 40 50 60 MSDNNVMSDL EIAQRATMRP IGDIAAAAGI NADAVELYGR YKAKIDPAKL IDPAGAPKRL 70 80 90 100 110 120 PGKVVLVSAM SPTPAGEGKS TTTVGLADSL ARAGRNVMIA LREPSLGPVL GMKGGATGGG 130 140 150 160 170 180 YSQVLPMEEI NLHFTGDFHA ITSANNALMA LVDNHIFQGN ELNIDPRRMT FKRVLDMNDR 190 200 210 220 230 240 SLREVIIGLG GPAQGVPRQD GFDITVASEI MAVFCLATDI ADLRARLGRI TFGYTYDREP 250 260 270 280 290 300 VTVADLGVQG ALTMLLRDAI KPNLVQTIAG TPALVHGGPF ANIAHGCNSL IATQTARRLA 310 320 330 340 350 360 DIVVTEAGFG ADLGAEKFMD IKARVAGVAP SAVVLVATVR ALKMHGGVAK DRLQEPNVEA 370 380 390 400 410 420 LAAGSANLRR HIRNVEKFGI TPVVAVNKFA TDTPEELDWL LEWCAGEGVQ AAVADVWGRG 430 440 450 460 470 480 GGGDGGDELA AKVLAALEAP HSFRHLYPLE LSVEDKIRTI VQEMYGADGV DFSVPALKRL 490 500 510 520 530 540 AEIEKNGWAG MPVCMAKTQY SFSDDATRLG APKGFTVHVR DLIPKTGAGF IVALTGAVMT 550 560 MPGLPKVPAA LRMDVDDTGK PLGLF

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK04280.1.
RefSeq	YP_832380.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JZ10.
SMR	A0JZ10. Positions 9-563.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JZ10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4444423.
GenomeReviews	Gene locus Arth_2901 in contig CP000454_GR.
KEGG	art:Arth_2901.
PATRIC	21001213. VBIArtSp72239_3289.
TIGR	Arth_2901.
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	EIMAVLC.
PhylomeDB	A0JZ10.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	ASP1667:ARTH_2901-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_ARTS2

Accession

Primary (citable) accession number: A0JZ10

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program