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A0JZ10

- FTHS_ARTS2

UniProt

A0JZ10 - FTHS_ARTS2

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Arth_2901
Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP290399:GHIF-2968-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Arth_2901
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000293032Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290399.Arth_2901.

Structurei

3D structure databases

ProteinModelPortaliA0JZ10.
SMRiA0JZ10. Positions 9-563.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JZ10-1 [UniParc]FASTAAdd to Basket

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MSDNNVMSDL EIAQRATMRP IGDIAAAAGI NADAVELYGR YKAKIDPAKL    50
IDPAGAPKRL PGKVVLVSAM SPTPAGEGKS TTTVGLADSL ARAGRNVMIA 100
LREPSLGPVL GMKGGATGGG YSQVLPMEEI NLHFTGDFHA ITSANNALMA 150
LVDNHIFQGN ELNIDPRRMT FKRVLDMNDR SLREVIIGLG GPAQGVPRQD 200
GFDITVASEI MAVFCLATDI ADLRARLGRI TFGYTYDREP VTVADLGVQG 250
ALTMLLRDAI KPNLVQTIAG TPALVHGGPF ANIAHGCNSL IATQTARRLA 300
DIVVTEAGFG ADLGAEKFMD IKARVAGVAP SAVVLVATVR ALKMHGGVAK 350
DRLQEPNVEA LAAGSANLRR HIRNVEKFGI TPVVAVNKFA TDTPEELDWL 400
LEWCAGEGVQ AAVADVWGRG GGGDGGDELA AKVLAALEAP HSFRHLYPLE 450
LSVEDKIRTI VQEMYGADGV DFSVPALKRL AEIEKNGWAG MPVCMAKTQY 500
SFSDDATRLG APKGFTVHVR DLIPKTGAGF IVALTGAVMT MPGLPKVPAA 550
LRMDVDDTGK PLGLF 565
Length:565
Mass (Da):59,652
Last modified:December 12, 2006 - v1
Checksum:i2534351725288ABE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK04280.1.
RefSeqiWP_011692739.1. NC_008541.1.
YP_832380.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK04280; ABK04280; Arth_2901.
GeneIDi4444423.
KEGGiart:Arth_2901.
PATRICi21001213. VBIArtSp72239_3289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK04280.1 .
RefSeqi WP_011692739.1. NC_008541.1.
YP_832380.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0JZ10.
SMRi A0JZ10. Positions 9-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_2901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK04280 ; ABK04280 ; Arth_2901 .
GeneIDi 4444423.
KEGGi art:Arth_2901.
PATRICi 21001213. VBIArtSp72239_3289.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ASP290399:GHIF-2968-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiFTHS_ARTS2
AccessioniPrimary (citable) accession number: A0JZ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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