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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 1311D-inositol 3-phosphateUniRule annotation
Binding sitei27 – 271UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei82 – 8211D-inositol 3-phosphateUniRule annotation
Binding sitei115 – 11511D-inositol 3-phosphateUniRule annotation
Binding sitei139 – 13911D-inositol 3-phosphateUniRule annotation
Binding sitei159 – 15911D-inositol 3-phosphateUniRule annotation
Binding sitei233 – 2331UDP-GlcNAcUniRule annotation
Binding sitei238 – 2381UDP-GlcNAcUniRule annotation
Binding sitei294 – 2941UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation
Metal bindingi303 – 3031Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi304 – 3041Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi306 – 3061Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei316 – 3161UDP-GlcNAcUniRule annotation
Binding sitei324 – 3241UDP-GlcNAcUniRule annotation
Metal bindingi330 – 3301MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciASP290399:GHIF-2967-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Arth_2900
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000000754 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421D-inositol 3-phosphate glycosyltransferasePRO_0000400111Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_2900.

Structurei

3D structure databases

ProteinModelPortaliA0JZ09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 202UDP-GlcNAc bindingUniRule annotation
Regioni24 – 2961D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiEOG647TVR.

Family and domain databases

HAMAPiMF_01695. MshA.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLIRRVAFL SLHTSPMEQP GSGDAGGMNV YVRALASALA ASGVEVEIFT
60 70 80 90 100
RSTSSGQPAV EHPDPGVCVH NVISGPPRKL PKEELPELLH SMVAEIERIR
110 120 130 140 150
QRQPHGRYDL IHSHYWVSGV AGLELSRLWG VPLVHTMHTM AKVKNLLLQS
160 170 180 190 200
GEKPEPRRRE DGELRIVDGA TRLIANTPAE AAELVSHYNA DFDHIDVAPP
210 220 230 240 250
GVDLTVFTPA FRPRSRAQLG VPAGKFHLLF AGRIQRLKGP QVLVKAAALL
260 270 280 290 300
RSRRPDIDLQ VTILGALSGA KDFDLKSLIS AAGMDDVVTH HPPVNAPELA
310 320 330 340 350
GWFRSADVVV MPSYSESFGL VALEAQACGT PVVATRVGGL SRAIFDGRTG
360 370 380 390 400
LLVDGHKAAD WADVLEALYD DPATRGDMGR AAALHAQGFG WQRTAAITLE
410 420
SYHAAVDQYI DSHRIPVGHS P
Length:421
Mass (Da):45,443
Last modified:December 12, 2006 - v1
Checksum:i23477940FA28AC61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK04279.1.
RefSeqiWP_011692738.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK04279; ABK04279; Arth_2900.
KEGGiart:Arth_2900.
PATRICi21001211. VBIArtSp72239_3288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK04279.1.
RefSeqiWP_011692738.1. NC_008541.1.

3D structure databases

ProteinModelPortaliA0JZ09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290399.Arth_2900.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK04279; ABK04279; Arth_2900.
KEGGiart:Arth_2900.
PATRICi21001211. VBIArtSp72239_3288.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiEOG647TVR.

Enzyme and pathway databases

BioCyciASP290399:GHIF-2967-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiMSHA_ARTS2
AccessioniPrimary (citable) accession number: A0JZ09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 12, 2006
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.