Reviewed, UniProtKB/Swiss-Prot A0JZ01 (GCP_ARTS2)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Arth_2892

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303258
Sites
	Metal binding	115	1	Zinc Potential
	Metal binding	119	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A0JZ01-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 538FBCF34794DCAE	FASTA	356	36,793
	10 20 30 40 50 60 MNRTQPLVLG IESSCDETGV GIVRGTALLS NTVSSSMEEH VRFGGVIPEI ASRAHLDAFV 70 80 90 100 110 120 PTLQEALADA GVQLDDVDAI AVTSGPGLAG ALMVGVCAAK ALAVATGKPL YAINHLVAHV 130 140 150 160 170 180 GVGLLQEENT LPEHLGALLV SGGHTEILRI RSITDDVELL GSTIDDAAGE AYDKVARLLG 190 200 210 220 230 240 LGYPGGPAID KLARTGNAKA IRFPRGLTQP KYMGTADEPG PHRYDWSFSG LKTAVARCVE 250 260 270 280 290 300 QFEARGDEVP VADIAAAFQE AVVDVITSKA VLACTENGIT ELLLGGGVAA NSRLRQLTEQ 310 320 330 340 350 RCRAAGIRLT VPPLELCTDN GAMVAALGAQ LVMAGIEPSG ISFAPDSSMP VTTVSA

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK04271.1.
RefSeq	YP_832371.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0JZ01.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4444449.
GenomeReviews	Gene locus Arth_2892 in contig CP000454_GR.
KEGG	art:Arth_2892.
TIGR	Arth_2892.
Phylogenomic databases
OMA	EHSAYGG.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ARTS2

Accession

Primary (citable) accession number: A0JZ01

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)