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A0JYU2 (A0JYU2_ARTS2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:Arth_2833
OrganismArthrobacter sp. (strain FB24) [Complete proteome] [HAMAP] EMBL ABK04212.1
Taxonomic identifier290399 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A0JYU2 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 4B8E05C8D6472D4A

FASTA35938,781
        10         20         30         40         50         60 
MTTSAVSIPM PSIPRRRRSP EDVLAAAPVP GPKKVLLAAP RGYCAGVDRA VIAVEKALEH 

        70         80         90        100        110        120 
YGPPVYVRKQ IVHNVHVVSS LEEKGAIFVD ETDEVPEGAL VIFSAHGVSP AVVQSAEDRG 

       130        140        150        160        170        180 
LRTIDATCPL VTKVHREAVR FAKDDFDILL IGHDGHEEVE GTAGEAPEHI QIINGPHEVD 

       190        200        210        220        230        240 
KVTVRDPEKV IWLSQTTLSV DETMETVRLL KERFPTLQDP PSDDICYATT NRQVAIKKIS 

       250        260        270        280        290        300 
PQADLVIVVG SANSSNSVRL VEVALEYGAK ASYRVDFANE VDEAWFEGVA TVGVTSGASV 

       310        320        330        340        350 
PEVLVKDVLR LLADYGYGTV EEVVTAEEDL LFSLPKELRA TLKKSGDVTR ALGGRGARA

« Hide

References

[1]"Complete sequence of chromosome 1 of Arthrobacter sp. FB24."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FB24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000454 Genomic DNA. Translation: ABK04212.1.
RefSeqYP_832312.1. NC_008541.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0JYU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4444665.
GenomeReviewsGene locus Arth_2833 in contig CP000454_GR.
KEGGart:Arth_2833.
PATRIC21001067. VBIArtSp72239_3217.
TIGRArth_2833.

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAAMAPECD.
PhylomeDBA0JYU2.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0JYU2_ARTS2
AccessionPrimary (citable) accession number: A0JYU2
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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