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A0JYM2

- GSA_ARTS2

UniProt

A0JYM2 - GSA_ARTS2

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciASP290399:GHIF-2829-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Arth_2763
    OrganismiArthrobacter sp. (strain FB24)
    Taxonomic identifieri290399 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000754: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382255Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei277 – 2771N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290399.Arth_2763.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JYM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiADIAHEN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0JYM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSSPRNEA LFDRARQLMP GGVNSPVRAF GSVGGTPRFM VSAKGAYLTD    50
    ADGAEYVDLV CSWGPALLGH AHPAVLEAVH AAVDRGLSFG ASTPDEANLA 100
    AIVKERVPAA ERVRMVSTGT EATMTAIRLA RGFTGRDLVI KFAGCYHGHL 150
    DGLLAAAGSG VATLALPGSA GVTAATAAET LVLPYNDLAA VEAAFAAHGS 200
    NIAAVITEAA PANMGVVTPG EGFNAGLSRI TREHGALLIV DEVLTGFRTG 250
    YSGYWGLTGG AADAAEPWSP DLLTFGKVIG GGMPTAALGG RADIMDYLAP 300
    LGPVYQAGTL SGNPVAMAAG VATLAHATPE VYSFIDARSL ELSAALSSAL 350
    DAAGVDHSIQ RAGNLFSVAF GTSARGVHNY DDAQGQEVFR YAPFFHSMLD 400
    SGVYLPPSVF EAWFLSAAHD DAAMNRIFDA LPAAARAAAS AAVPAGL 447
    Length:447
    Mass (Da):45,602
    Last modified:December 12, 2006 - v1
    Checksum:iA539D1F70DA7300B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK04142.1.
    RefSeqiWP_011692603.1. NC_008541.1.
    YP_832242.1. NC_008541.1.

    Genome annotation databases

    EnsemblBacteriaiABK04142; ABK04142; Arth_2763.
    GeneIDi4444562.
    KEGGiart:Arth_2763.
    PATRICi21000919. VBIArtSp72239_3143.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK04142.1 .
    RefSeqi WP_011692603.1. NC_008541.1.
    YP_832242.1. NC_008541.1.

    3D structure databases

    ProteinModelPortali A0JYM2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290399.Arth_2763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK04142 ; ABK04142 ; Arth_2763 .
    GeneIDi 4444562.
    KEGGi art:Arth_2763.
    PATRICi 21000919. VBIArtSp72239_3143.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi ADIAHEN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci ASP290399:GHIF-2829-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FB24.

    Entry informationi

    Entry nameiGSA_ARTS2
    AccessioniPrimary (citable) accession number: A0JYM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3