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A0JYM2

- GSA_ARTS2

UniProt

A0JYM2 - GSA_ARTS2

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, Arth_2763
Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciASP290399:GHIF-2829-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Arth_2763
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_0000382255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_2763.

Structurei

3D structure databases

ProteinModelPortaliA0JYM2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiADIAHEN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JYM2-1 [UniParc]FASTAAdd to Basket

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MTSSSPRNEA LFDRARQLMP GGVNSPVRAF GSVGGTPRFM VSAKGAYLTD    50
ADGAEYVDLV CSWGPALLGH AHPAVLEAVH AAVDRGLSFG ASTPDEANLA 100
AIVKERVPAA ERVRMVSTGT EATMTAIRLA RGFTGRDLVI KFAGCYHGHL 150
DGLLAAAGSG VATLALPGSA GVTAATAAET LVLPYNDLAA VEAAFAAHGS 200
NIAAVITEAA PANMGVVTPG EGFNAGLSRI TREHGALLIV DEVLTGFRTG 250
YSGYWGLTGG AADAAEPWSP DLLTFGKVIG GGMPTAALGG RADIMDYLAP 300
LGPVYQAGTL SGNPVAMAAG VATLAHATPE VYSFIDARSL ELSAALSSAL 350
DAAGVDHSIQ RAGNLFSVAF GTSARGVHNY DDAQGQEVFR YAPFFHSMLD 400
SGVYLPPSVF EAWFLSAAHD DAAMNRIFDA LPAAARAAAS AAVPAGL 447
Length:447
Mass (Da):45,602
Last modified:December 12, 2006 - v1
Checksum:iA539D1F70DA7300B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK04142.1.
RefSeqiWP_011692603.1. NC_008541.1.
YP_832242.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK04142; ABK04142; Arth_2763.
GeneIDi4444562.
KEGGiart:Arth_2763.
PATRICi21000919. VBIArtSp72239_3143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK04142.1 .
RefSeqi WP_011692603.1. NC_008541.1.
YP_832242.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0JYM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_2763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK04142 ; ABK04142 ; Arth_2763 .
GeneIDi 4444562.
KEGGi art:Arth_2763.
PATRICi 21000919. VBIArtSp72239_3143.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi ADIAHEN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci ASP290399:GHIF-2829-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiGSA_ARTS2
AccessioniPrimary (citable) accession number: A0JYM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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