A0JXZ6 (ILVC_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	Arth_2537

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000050477
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A0JXZ6 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 3FE814BF4EFAAC1E	FASTA	341	37,189
	10 20 30 40 50 60 MTEMFYDDDA DLSIIQGRKV AIVGYGSQGH AHALNLRDSG VEVTIALKEG SSSIAKAQDA 70 80 90 100 110 120 GFTVKNVADA AEWADVIMIL APDQHQRSIY NDSIKDKLTP GKALAFAHGF NIRFGYIKAP 130 140 150 160 170 180 EGVDVILIAP KAPGHTVRRE FEAGRGIPDI IAVEQDATGA AWDLAKSYAK AIGGTRAGVI 190 200 210 220 230 240 KTTFTEETET DLFGEQAVLC GGVSQLVQYG FETLTEAGYQ PQIAYFEVLH ELKLIVDLMW 250 260 270 280 290 300 EGGIAKQRWS VSDTAEYGDY VSGPRVITPE VKENMKAVLA DIQNGAFAKR FIEDQDNGGV 310 320 330 340 EFKALRAKAE QHPIESVGRE LRGLFSWQQQ DEDYVEGSAA R

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK03916.1.
RefSeq	YP_832016.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JXZ6.
SMR	A0JXZ6. Positions 3-328.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JXZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4444945.
GenomeReviews	Gene locus Arth_2537 in contig CP000454_GR.
KEGG	art:Arth_2537.
PATRIC	21000449. VBIArtSp72239_2913.
TIGR	Arth_2537.
Phylogenomic databases
eggNOG	COG0059.
HOGENOM	HBG286525.
OMA	MAYAKGI.
PhylomeDB	A0JXZ6.
ProtClustDB	PRK05479.
Enzyme and pathway databases
BioCyc	ASP1667:ARTH_2537-MONOMER.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_ARTS2

Accession

Primary (citable) accession number: A0JXZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program