Reviewed, UniProtKB/Swiss-Prot A0JXN9 (XYLA_ARTS2)

Names and origin

Protein names

Recommended name:
    Xylose isomerase
    EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	Arth_2430

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Xylose isomerase HAMAP MF_00455		PRO_1000026428
Sites
	Active site	54	1	By similarity
	Active site	57	1	By similarity
	Metal binding	181	1	Magnesium 1 By similarity
	Metal binding	217	1	Magnesium 1 By similarity
	Metal binding	217	1	Magnesium 2 By similarity
	Metal binding	220	1	Magnesium 2 By similarity
	Metal binding	245	1	Magnesium 1 By similarity
	Metal binding	255	1	Magnesium 2 By similarity
	Metal binding	257	1	Magnesium 2 By similarity
	Metal binding	293	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JXN9-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: FCEE25EBD87D6D40	FASTA	395	42,917
	10 20 30 40 50 60 MTLQPTPADR FTFGLWTVGW TGADPFGVAT RPALDPVEAV HKLSELGAYG ITFHDNDLVP 70 80 90 100 110 120 FDATASEREL ILKNFKAALA ETGLKTPMVT TNLFSHPVFK DGGFTSNDRS VRRFALSKVL 130 140 150 160 170 180 QNIDLAAELG AETFVMWGGR EGSEYDGSKD LSAALDRMKE GVDTAAAYIK DKGYGLRIAL 190 200 210 220 230 240 EPKPNEPRGD IFLPTVGHGL AFIAQLEHGD IVGLNPETGH EQMAGLNFTH GIAQALWAGK 250 260 270 280 290 300 LFHIDLNGQR GIKYDQDLVF GHGDLTSAFF TVDLLENGFP NGGPKYDGPR HFDYKPSRTD 310 320 330 340 350 360 GYDGVWESAK SNMSMYLLLK ERALAFRADP DVQEALKTSG VFELGEPTLA AGETTADLLA 370 380 390 DASAFAEFDA DAAAQRSFAF VRLNQLAIEH LLGAR

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK03809.1.
RefSeq	YP_831909.1.
3D structure databases
SMR	A0JXN9. Positions 3-395.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JXN9.
Genome annotation databases
GeneID	4445032.
GenomeReviews	Gene locus Arth_2430 in contig CP000454_GR.
KEGG	art:Arth_2430.
TIGR	Arth_2430.
Phylogenomic databases
OMA	FDATASE.
Family and domain databases
HAMAP	MF_00455. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013453. XylA_actinobac. IPR001998. Xylose_isomerase. IPR018115. Xylose_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02631. xylA_Arthro. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_ARTS2

Accession

Primary (citable) accession number: A0JXN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)