A0JXL3 (A0JXL3_ARTS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 1 HAMAP MF_00444

Gene names

Name:	clpP1 HAMAP MF_00444
Ordered Locus Names:	Arth_2404

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP] EMBL ABK03783.1

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	120	1	By similarity HAMAP MF_00444
	Active site	145	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A0JXL3 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: F57300DE9DAAA076	FASTA	226	24,785
	10 20 30 40 50 60 MIPGEMNMNY NFGSSAGNLP TSRYVLPQFE ERTPYGFKRQ DPYTKLFEDR IIFLGVQVDD 70 80 90 100 110 120 ASADDVMAQL LVLESTDPDR DITLYINSPG GSFTAMTAIY DTMQYIRPEI QTVCLGQAAS 130 140 150 160 170 180 AAAVLLAAGT PGKRLALPNA RVLIHQPALS GGQGGQASDL EIQAAEVMRM RSWLEDTLAK 190 200 210 220 HSGRTSEQVN NDIERDKILT AAEAQSYGLI DQVLDSRKIK PQAISR

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK03783.1.
RefSeq	YP_831883.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JXL3.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JXL3.
Protein family/group databases
MEROPS	S14.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4445003.
GenomeReviews	Gene locus Arth_2404 in contig CP000454_GR.
KEGG	art:Arth_2404.
PATRIC	21000159. VBIArtSp72239_2775.
TIGR	Arth_2404.
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	QDPYTKL.
ProtClustDB	PRK12553.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0JXL3_ARTS2

Accession

Primary (citable) accession number: A0JXL3

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)