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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3826C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi128 – 1358ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciASP290399:GHIF-2451-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:Arth_2403
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429ATP-dependent Clp protease ATP-binding subunit ClpXPRO_1000024513Add
BLAST

Proteomic databases

PRIDEiA0JXL2.

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_2403.

Structurei

3D structure databases

ProteinModelPortaliA0JXL2.
SMRiA0JXL2. Positions 7-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3826C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1219.
HOGENOMiHOG000010093.
KOiK03544.
OMAiILLDIMY.
OrthoDBiEOG625JZK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JXL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIGESTDL LKCSFCGKSQ KQVRKLIAGP GVYICDECIE LCNEIIEEEL
60 70 80 90 100
AEVADLGSFE LPKPREIYDF LQEYVIGQEP AKRSLAVAVY NHYKRIQAGH
110 120 130 140 150
APKSGSLAEG VHHDDVEIAK SNILLIGPTG CGKTYLAQTL ARRLNVPFAV
160 170 180 190 200
ADATALTEAG YVGEDVENIL LKLIQAADYD VKKAEQGIIY IDEIDKISRK
210 220 230 240 250
SENPSITRDV SGEGVQQALL KILEGTVASV PPQGGRKHPH QEFIQIDTTN
260 270 280 290 300
VLFIVAGAFA GLEDIIGSRS GRKGIGFGAP LNEVKNNSDS YGEVMPEDLL
310 320 330 340 350
KFGLIPEFIG RLPVITTVSN LDRPALIQIL STPKNALVKQ YQKMFQLDGV
360 370 380 390 400
ELLFDDEALD VIADQALERG TGARGLRAIM EEVLLPVMFD LPSRDDIASV
410 420
VITADVVAKK APPTMIAHDV VAKRRNKSA
Length:429
Mass (Da):46,687
Last modified:December 12, 2006 - v1
Checksum:iEF172172D5B99044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK03782.1.
RefSeqiWP_011692245.1. NC_008541.1.
YP_831882.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK03782; ABK03782; Arth_2403.
KEGGiart:Arth_2403.
PATRICi21000157. VBIArtSp72239_2774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA. Translation: ABK03782.1.
RefSeqiWP_011692245.1. NC_008541.1.
YP_831882.1. NC_008541.1.

3D structure databases

ProteinModelPortaliA0JXL2.
SMRiA0JXL2. Positions 7-50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290399.Arth_2403.

Proteomic databases

PRIDEiA0JXL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK03782; ABK03782; Arth_2403.
KEGGiart:Arth_2403.
PATRICi21000157. VBIArtSp72239_2774.

Phylogenomic databases

eggNOGiCOG1219.
HOGENOMiHOG000010093.
KOiK03544.
OMAiILLDIMY.
OrthoDBiEOG625JZK.

Enzyme and pathway databases

BioCyciASP290399:GHIF-2451-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiCLPX_ARTS2
AccessioniPrimary (citable) accession number: A0JXL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.