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A0JXL2

- CLPX_ARTS2

UniProt

A0JXL2 - CLPX_ARTS2

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri13 – 3826C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi128 – 1358ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciASP290399:GHIF-2451-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:Arth_2403
    OrganismiArthrobacter sp. (strain FB24)
    Taxonomic identifieri290399 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000754: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429ATP-dependent Clp protease ATP-binding subunit ClpXPRO_1000024513Add
    BLAST

    Proteomic databases

    PRIDEiA0JXL2.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi290399.Arth_2403.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JXL2.
    SMRiA0JXL2. Positions 7-50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri13 – 3826C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiHVEIAKS.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0JXL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARIGESTDL LKCSFCGKSQ KQVRKLIAGP GVYICDECIE LCNEIIEEEL    50
    AEVADLGSFE LPKPREIYDF LQEYVIGQEP AKRSLAVAVY NHYKRIQAGH 100
    APKSGSLAEG VHHDDVEIAK SNILLIGPTG CGKTYLAQTL ARRLNVPFAV 150
    ADATALTEAG YVGEDVENIL LKLIQAADYD VKKAEQGIIY IDEIDKISRK 200
    SENPSITRDV SGEGVQQALL KILEGTVASV PPQGGRKHPH QEFIQIDTTN 250
    VLFIVAGAFA GLEDIIGSRS GRKGIGFGAP LNEVKNNSDS YGEVMPEDLL 300
    KFGLIPEFIG RLPVITTVSN LDRPALIQIL STPKNALVKQ YQKMFQLDGV 350
    ELLFDDEALD VIADQALERG TGARGLRAIM EEVLLPVMFD LPSRDDIASV 400
    VITADVVAKK APPTMIAHDV VAKRRNKSA 429
    Length:429
    Mass (Da):46,687
    Last modified:December 12, 2006 - v1
    Checksum:iEF172172D5B99044
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK03782.1.
    RefSeqiWP_011692245.1. NC_008541.1.
    YP_831882.1. NC_008541.1.

    Genome annotation databases

    EnsemblBacteriaiABK03782; ABK03782; Arth_2403.
    GeneIDi4445002.
    KEGGiart:Arth_2403.
    PATRICi21000157. VBIArtSp72239_2774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK03782.1 .
    RefSeqi WP_011692245.1. NC_008541.1.
    YP_831882.1. NC_008541.1.

    3D structure databases

    ProteinModelPortali A0JXL2.
    SMRi A0JXL2. Positions 7-50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290399.Arth_2403.

    Proteomic databases

    PRIDEi A0JXL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK03782 ; ABK03782 ; Arth_2403 .
    GeneIDi 4445002.
    KEGGi art:Arth_2403.
    PATRICi 21000157. VBIArtSp72239_2774.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi HVEIAKS.
    OrthoDBi EOG625JZK.

    Enzyme and pathway databases

    BioCyci ASP290399:GHIF-2451-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FB24.

    Entry informationi

    Entry nameiCLPX_ARTS2
    AccessioniPrimary (citable) accession number: A0JXL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3