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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 38C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi128 – 135ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:Arth_2403
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000000754 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000245131 – 429ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST429

Proteomic databases

PRIDEiA0JXL2

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi290399.Arth_2403

Structurei

3D structure databases

ProteinModelPortaliA0JXL2
SMRiA0JXL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 38C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN Bacteria
COG1219 LUCA
HOGENOMiHOG000010093
KOiK03544
OMAiDIMYDLP
OrthoDBiPOG091H01U4

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175 ClpX, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004487 Clp_protease_ATP-bd_su_ClpX
IPR027417 P-loop_NTPase
IPR010603 Znf_CppX_C4
IPR038366 Znf_CppX_C4_sf
PANTHERiPTHR11262 PTHR11262, 2 hits
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
PF06689 zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SM00994 zf-C4_ClpX, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00382 clpX, 1 hit

Sequencei

Sequence statusi: Complete.

A0JXL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIGESTDL LKCSFCGKSQ KQVRKLIAGP GVYICDECIE LCNEIIEEEL
60 70 80 90 100
AEVADLGSFE LPKPREIYDF LQEYVIGQEP AKRSLAVAVY NHYKRIQAGH
110 120 130 140 150
APKSGSLAEG VHHDDVEIAK SNILLIGPTG CGKTYLAQTL ARRLNVPFAV
160 170 180 190 200
ADATALTEAG YVGEDVENIL LKLIQAADYD VKKAEQGIIY IDEIDKISRK
210 220 230 240 250
SENPSITRDV SGEGVQQALL KILEGTVASV PPQGGRKHPH QEFIQIDTTN
260 270 280 290 300
VLFIVAGAFA GLEDIIGSRS GRKGIGFGAP LNEVKNNSDS YGEVMPEDLL
310 320 330 340 350
KFGLIPEFIG RLPVITTVSN LDRPALIQIL STPKNALVKQ YQKMFQLDGV
360 370 380 390 400
ELLFDDEALD VIADQALERG TGARGLRAIM EEVLLPVMFD LPSRDDIASV
410 420
VITADVVAKK APPTMIAHDV VAKRRNKSA
Length:429
Mass (Da):46,687
Last modified:December 12, 2006 - v1
Checksum:iEF172172D5B99044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA Translation: ABK03782.1
RefSeqiWP_011692245.1, NC_008541.1

Genome annotation databases

EnsemblBacteriaiABK03782; ABK03782; Arth_2403
KEGGiart:Arth_2403

Similar proteinsi

Entry informationi

Entry nameiCLPX_ARTS2
AccessioniPrimary (citable) accession number: A0JXL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health