Reviewed, UniProtKB/Swiss-Prot A0JX82 (AROB_ARTS2)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Arth_2272

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094453

Sequences

	Sequence		Length	Mass (Da)
	A0JX82-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: F825AA32B0CC88AD	FASTA	363	38,981
	10 20 30 40 50 60 MSSESTVIKV TGKSAADNYD VVVGRGLLGR LPELLGERVK RVLVIHPRAL RLTGDTVRDE 70 80 90 100 110 120 LASAGFTALT AEIPDAEEGK HIQVAAFCWQ VLGQNDFTRS DAVVAVGGGA VTDLAGFVAA 130 140 150 160 170 180 TWLRGVKVIH MPTSLLGMVD ASVGGKTGIN TAEGKNLVGA FHPPAAVLAD LDTLSTLPKN 190 200 210 220 230 240 ELISGMAEVI KCGFIADPAI LDLVEKDPSA VTDPQSAFLR ELIERAIAVK ADVVSEDLKE 250 260 270 280 290 300 TGRREILNYG HTLGHAIELV ERYSWRHGAA VSVGMMFAAE LARSVGRLSD ADADRHRTIL 310 320 330 340 350 360 ETLGLPITYR RDRWQGLLDG MRRDKKSRGD LLRFVVLDGI ARPGILDVPD TSLLFAAYQE IAS

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK03652.1.
RefSeq	YP_831752.1.
3D structure databases
SMR	A0JX82. Positions 8-360.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JX82.
Genome annotation databases
GeneID	4445315.
GenomeReviews	Gene locus Arth_2272 in contig CP000454_GR.
KEGG	art:Arth_2272.
TIGR	Arth_2272.
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	VAAFCWQ.
PhylomeDB	A0JX82.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ARTS2

Accession

Primary (citable) accession number: A0JX82

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 12, 2006
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)