ID   PYRB_ARTS2              Reviewed;         337 AA.
AC   A0JX76;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=Arth_2266;
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K.,
RA   Nakatsu C.H., Richardson P.;
RT   "Complete sequence of chromosome 1 of Arthrobacter sp. FB24.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000454; ABK03646.1; -; Genomic_DNA.
DR   RefSeq; YP_831746.1; -.
DR   GeneID; 4445309; -.
DR   GenomeReviews; CP000454_GR; Arth_2266.
DR   KEGG; art:Arth_2266; -.
DR   TIGR; Arth_2266; -.
DR   OMA; A0JX76; RTVVNLF.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    337       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000301552.
SQ   SEQUENCE   337 AA;  36429 MW;  684AD2923955B069 CRC64;
     MKHLLSTEDL SLANAIRILD TAEEMAAVGD REVKKLPALR GRTVVNLFFE DSTRTRISFE
     AAAKRLSADV INFAAKGSSV SKGESLKDTA QTLAAMGADA VVIRHWASGA PHRLAATDWI
     DAAVINAGDG THEHPTQALL DAFTMRRHWA RLHGTPSAGA DLKGMRVAIA GDVLHSRVAR
     SNVWLLRTLG AEVTLVAPPT LLPIGVGQWP CSVSYDMDET LAKGVDAVVM LRVQGERMNA
     SFFPTTREYS RRWGFDDNRL RALDSLGLKD TIIMHPGPMN RGLEISSAAA DSPRSTVLAQ
     VRNGVSVRMA ALYLLLSGDT REPALTPNAA YSTKESH
//