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A0JX57

- SYL_ARTS2

UniProt

A0JX57 - SYL_ARTS2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei609 – 6091ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASP290399:GHIF-2293-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Arth_2247
    OrganismiArthrobacter sp. (strain FB24)
    Taxonomic identifieri290399 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000754: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 843843Leucine--tRNA ligasePRO_0000334729Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290399.Arth_2247.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JX57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi61 – 7111"HIGH" regionAdd
    BLAST
    Motifi606 – 6105"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiEICAPEQ.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JX57-1 [UniParc]FASTAAdd to Basket

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    MSVQPETETG TAAVATEGPE EGTYSFAAME AKWPQVWEDL KVFTPVDDGS    50
    RERRYVLDMF PYPSGDLHMG HAEAFAMGDV VARYLRQKGY DVLHPIGWDS 100
    FGLPAENAAI KRNAHPSEWT YANIDTQAAS FKRYAISADW SRRLHTSDPE 150
    YYRWTQWLFK RFYERGLAYR KDSPVNWCPK DQTVLANEQV VNGACERCGT 200
    AVTKKSLNQW YFKITDYADR LLDDMDELRG HWPERVLAMQ KNWIGRSEGA 250
    HVNFVIEAAG DKPAKDVTVF TTRPDTLYGA TFFVVAADAP MAVELVTDEH 300
    AAALDAYREQ VKALSEIERQ STEREKTGVF TGRYAVNPLN GEKLPVWAAD 350
    YVLADYGTGA IMAVPAHDQR DLDFARTFDL PVRAVLDTGE DDPAVTGKAT 400
    AGEGTLINSG VLDGLPKAEA IPTAIDMLEK QGTGEKFVNF RLRDWLLSRQ 450
    RFWGTPIPII HCPACGEVPV PDDQLPVTLP ADLRGEDLSP KGTSPLAAAE 500
    AWVNVECPNC HGPAKRDTDT MDTFVDSSWY FLRFVSPQYT EGPFDPKKIN 550
    DWMPVGQYVG GVEHAILHLL YARFFTKVIH DLGMIDADEP FSALLNQGQV 600
    LNGGKAMSKS LGNGVDLGEQ LDKYGVDAVR LTMIFASPPE DDVDWADVSP 650
    SGSAKFLARA WRLAQDVSSA PGADAAQGDR ALRSVTHRTI ADAAALLDSN 700
    KFNVVVAKLM ELVNATRKTI DAASGAGGAD PAVREAAEAV AVILSLFAPY 750
    TAEDMWNVLG HPASVANAGW PSHDEALLVQ DTVTAVVQVQ GKVRDRLEVS 800
    PEIGEDELRE LALASENVQR ALDGRGIRTV IVRAPKLVNI VPA 843
    Length:843
    Mass (Da):92,600
    Last modified:December 12, 2006 - v1
    Checksum:i9C5CE6DF8B5BFEB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK03627.1.
    RefSeqiWP_011692091.1. NC_008541.1.
    YP_831727.1. NC_008541.1.

    Genome annotation databases

    EnsemblBacteriaiABK03627; ABK03627; Arth_2247.
    GeneIDi4445169.
    KEGGiart:Arth_2247.
    PATRICi20999837. VBIArtSp72239_2616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK03627.1 .
    RefSeqi WP_011692091.1. NC_008541.1.
    YP_831727.1. NC_008541.1.

    3D structure databases

    ProteinModelPortali A0JX57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290399.Arth_2247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK03627 ; ABK03627 ; Arth_2247 .
    GeneIDi 4445169.
    KEGGi art:Arth_2247.
    PATRICi 20999837. VBIArtSp72239_2616.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi EICAPEQ.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ASP290399:GHIF-2293-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FB24.

    Entry informationi

    Entry nameiSYL_ARTS2
    AccessioniPrimary (citable) accession number: A0JX57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3