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A0JWX7 (UPPP_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Arth_2167
OrganismArthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]
Taxonomic identifier290399 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290682

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane264 – 28421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0JWX7 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 756D006C6B06E5CC

FASTA28631,290
        10         20         30         40         50         60 
MLHDVGSINV NWFEAALLGL VQGLTEFLPI SSSAHLRIVG SFLPNAADPG AAFTAITQLG 

        70         80         90        100        110        120 
TETAVIVYFW RDIVRIVKAW AGTLTRRVPT DDPDARMGWL VILGSLPIIV LGLIFQDQIE 

       130        140        150        160        170        180 
SVLRSLWIVA TMLIVFGLIL AVADAVGRQE RELTRLTYKH GIFYGFAQAM ALIPGVSRSG 

       190        200        210        220        230        240 
GTITAGLLMG YTREAAARYS FLLAIPAVFG SGLYQLYKVM SKDGITGPYG LPETALATLI 

       250        260        270        280 
AFVVGYVIIG WFLKFVSTRS YRLFVWYRIF LGLALYLLLG FNVISA 

« Hide

References

[1]"Complete sequence of chromosome 1 of Arthrobacter sp. FB24."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FB24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000454 Genomic DNA. Translation: ABK03547.1.
RefSeqYP_831647.1. NC_008541.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290399.Arth_2167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK03547; ABK03547; Arth_2167.
GeneID4445193.
KEGGart:Arth_2167.
PATRIC20999675. VBIArtSp72239_2535.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycASP290399:GHIF-2213-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ARTS2
AccessionPrimary (citable) accession number: A0JWX7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families