Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0JWX7

- UPPP_ARTS2

UniProt

A0JWX7 - UPPP_ARTS2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciASP290399:GHIF-2213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Arth_2167
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Undecaprenyl-diphosphatasePRO_0000290682Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290399.Arth_2167.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11721HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalUniRule annotationAdd
BLAST
Transmembranei156 – 17621HelicalUniRule annotationAdd
BLAST
Transmembranei200 – 22021HelicalUniRule annotationAdd
BLAST
Transmembranei236 – 25621HelicalUniRule annotationAdd
BLAST
Transmembranei264 – 28421HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JWX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHDVGSINV NWFEAALLGL VQGLTEFLPI SSSAHLRIVG SFLPNAADPG
60 70 80 90 100
AAFTAITQLG TETAVIVYFW RDIVRIVKAW AGTLTRRVPT DDPDARMGWL
110 120 130 140 150
VILGSLPIIV LGLIFQDQIE SVLRSLWIVA TMLIVFGLIL AVADAVGRQE
160 170 180 190 200
RELTRLTYKH GIFYGFAQAM ALIPGVSRSG GTITAGLLMG YTREAAARYS
210 220 230 240 250
FLLAIPAVFG SGLYQLYKVM SKDGITGPYG LPETALATLI AFVVGYVIIG
260 270 280
WFLKFVSTRS YRLFVWYRIF LGLALYLLLG FNVISA
Length:286
Mass (Da):31,290
Last modified:December 12, 2006 - v1
Checksum:i756D006C6B06E5CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK03547.1.
RefSeqiWP_011692013.1. NC_008541.1.
YP_831647.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK03547; ABK03547; Arth_2167.
GeneIDi4445193.
KEGGiart:Arth_2167.
PATRICi20999675. VBIArtSp72239_2535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK03547.1 .
RefSeqi WP_011692013.1. NC_008541.1.
YP_831647.1. NC_008541.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_2167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK03547 ; ABK03547 ; Arth_2167 .
GeneIDi 4445193.
KEGGi art:Arth_2167.
PATRICi 20999675. VBIArtSp72239_2535.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci ASP290399:GHIF-2213-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiUPPP_ARTS2
AccessioniPrimary (citable) accession number: A0JWX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3