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A0JWX7

- UPPP_ARTS2

UniProt

A0JWX7 - UPPP_ARTS2

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciASP290399:GHIF-2213-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Arth_2167
    OrganismiArthrobacter sp. (strain FB24)
    Taxonomic identifieri290399 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000754: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Undecaprenyl-diphosphatasePRO_0000290682Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290399.Arth_2167.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei126 – 14621HelicalUniRule annotationAdd
    BLAST
    Transmembranei156 – 17621HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei236 – 25621HelicalUniRule annotationAdd
    BLAST
    Transmembranei264 – 28421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiIEGPFRD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0JWX7-1 [UniParc]FASTAAdd to Basket

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    MLHDVGSINV NWFEAALLGL VQGLTEFLPI SSSAHLRIVG SFLPNAADPG    50
    AAFTAITQLG TETAVIVYFW RDIVRIVKAW AGTLTRRVPT DDPDARMGWL 100
    VILGSLPIIV LGLIFQDQIE SVLRSLWIVA TMLIVFGLIL AVADAVGRQE 150
    RELTRLTYKH GIFYGFAQAM ALIPGVSRSG GTITAGLLMG YTREAAARYS 200
    FLLAIPAVFG SGLYQLYKVM SKDGITGPYG LPETALATLI AFVVGYVIIG 250
    WFLKFVSTRS YRLFVWYRIF LGLALYLLLG FNVISA 286
    Length:286
    Mass (Da):31,290
    Last modified:December 12, 2006 - v1
    Checksum:i756D006C6B06E5CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK03547.1.
    RefSeqiWP_011692013.1. NC_008541.1.
    YP_831647.1. NC_008541.1.

    Genome annotation databases

    EnsemblBacteriaiABK03547; ABK03547; Arth_2167.
    GeneIDi4445193.
    KEGGiart:Arth_2167.
    PATRICi20999675. VBIArtSp72239_2535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK03547.1 .
    RefSeqi WP_011692013.1. NC_008541.1.
    YP_831647.1. NC_008541.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290399.Arth_2167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK03547 ; ABK03547 ; Arth_2167 .
    GeneIDi 4445193.
    KEGGi art:Arth_2167.
    PATRICi 20999675. VBIArtSp72239_2535.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi IEGPFRD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci ASP290399:GHIF-2213-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FB24.

    Entry informationi

    Entry nameiUPPP_ARTS2
    AccessioniPrimary (citable) accession number: A0JWX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3