Reviewed, UniProtKB/Swiss-Prot A0JVK7 (HIS3_ARTS2)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-AMP cyclohydrolase
      Short name=PRA-CH
    EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	Arth_1683

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_1000063387

Sequences

	Sequence		Length	Mass (Da)
	A0JVK7-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: AD5BA9D5A158D79B	FASTA	134	14,234
	10 20 30 40 50 60 MSEQPAPAPV PVLPAEVADA LKRDAAGLVA AVVQQFDTNE VLMLGWMDDE ALRRTMTSGR 70 80 90 100 110 120 VTFYSRSRQE YWRKGDTSGH VQWVKSVALD CDGDALLVRV DQVGAACHTG TRTCFDGRGL 130 PVVAGDAGAA GNAS

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK03077.1.
RefSeq	YP_831177.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4445789.
GenomeReviews	Gene locus Arth_1683 in contig CP000454_GR.
KEGG	art:Arth_1683.
TIGR	Arth_1683.
Phylogenomic databases
OMA	A0JVK7. MMAWMDD.
Family and domain databases
HAMAP	MF_01021. [Tree]
InterPro	IPR002496. PRA_CycHdrlase. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_cyclohydro. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_ARTS2

Accession

Primary (citable) accession number: A0JVK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)