A0JVG9 (DXS_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	Arth_1645

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000019006

Sequences

	Sequence		Length	Mass (Da)
	A0JVG9 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: F3CB7CA49925476A	FASTA	657	70,491
	10 20 30 40 50 60 MGILDTIRNP QDLSKLTEEQ LSQLAAEVRS FLIGNVSQTG GHLGPNLGVV ELTMAVHRIF 70 80 90 100 110 120 DSPRDSIVFD TGHQSYVHKL LTGRQDFSTL RQEGGMSGYP DRGESEHDIV ESSHASSSLS 130 140 150 160 170 180 WADGISRARQ LTGDGDRYVI AVVGDGALTG GMAWEAINNI AADKRRRVVI VVNDNGRSYA 190 200 210 220 230 240 PTVGGFADYL ASLRPTIDSF RAAPAYEGTL DWWKRKLQNG GPVGQFTYRS LHAMKKGIKD 250 260 270 280 290 300 WWAPQGMFED LGMKYIGPVD GHNLQAMEHA LSTAKNYAGP VIVHAMTEKG HGYAPARAHE 310 320 330 340 350 360 ADQFHAVGII DPETGVPTEA GGAQSWTSVF ADEIAAIADE RKDIVGITGA MLIPVGLHKF 370 380 390 400 410 420 AARHPERVFD VGIAEQHALT SAAGMAFGGL HPVVAVYATF LNRAFDQLLM DVALHKAGVT 430 440 450 460 470 480 IVLDRAGVTG PDGASHHGMW DMAMVQIVPG LHLAAPRDAT RLREELREAV AIEDAPTVVR 490 500 510 520 530 540 YSKGNVGAEV EALERLSDGV DVLARRPAGS SENDVLIVSV GAMSELALDV SNRLGAQGIS 550 560 570 580 590 600 STVVDPRWLL PVRKSIIALA ARHRLVICIE DGVRAGGVGS RIRQEMRAAG VDTALNEVGL 610 620 630 640 650 PVEFLDHGTR AQVLERVGLT ARQITHDVVA QVLGTKVPFA RPLPGQEHPT TGSLPKL

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK03039.1.
RefSeq	YP_831139.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JVG9.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JVG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4445837.
GenomeReviews	Gene locus Arth_1645 in contig CP000454_GR.
KEGG	art:Arth_1645.
PATRIC	20998601. VBIArtSp72239_2006.
TIGR	Arth_1645.
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	QYDISYM.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	ASP1667:ARTH_1645-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ARTS2

Accession

Primary (citable) accession number: A0JVG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program