A0JVG0 (A0JVG0_ARTS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116

Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116

Gene names

Name:	dut HAMAP MF_00116
Ordered Locus Names:	Arth_1636

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP] EMBL ABK03030.1

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116
Cofactor	Magnesium By similarity. HAMAP MF_00116
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116
Sequence similarities	Belongs to the dUTPase family. HAMAP MF_00116

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00116
Ligand	Magnesium HAMAP MF_00116 Metal-binding HAMAP MF_00116
Molecular function	Hydrolase HAMAP MF_00116 EMBL ABK03030.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	89 – 91	3	Substrate binding By similarity HAMAP MF_00116
	Region	106 – 108	3	Substrate binding By similarity HAMAP MF_00116
Sites
	Binding site	102	1	Substrate By similarity HAMAP MF_00116

Sequences

	Sequence		Length	Mass (Da)
	A0JVG0 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 71B4902EFD79008A	FASTA	182	18,712
	10 20 30 40 50 60 MTEETAAVST LPSDSPEGSA AAYGSPTLSV QLKMLDAGLE APSYAHPGDA GADLRAREDV 70 80 90 100 110 120 VLEPGERRLV PTGVSIALPN GFVALIHPRS GLATKHGLTV VNAPGTVDAG YRGEIAVTLL 130 140 150 160 170 180 NTDREKSIEL RRGDRIAQMV IQRVEYAQFV AVAELSDSVR GDGGFGSTGG FGVAGGVATP QA

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK03030.1.
RefSeq	YP_831130.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JVG0.
SMR	A0JVG0. Positions 29-158.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JVG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4445828.
GenomeReviews	Gene locus Arth_1636 in contig CP000454_GR.
KEGG	art:Arth_1636.
PATRIC	20998583. VBIArtSp72239_1997.
TIGR	Arth_1636.
Phylogenomic databases
eggNOG	COG0756.
HOGENOM	HBG436079.
OMA	KIAQMVI.
PhylomeDB	A0JVG0.
ProtClustDB	CLSK779867.
Family and domain databases
HAMAP	MF_00116. dUTPase_bact. [Tree]
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0JVG0_ARTS2

Accession

Primary (citable) accession number: A0JVG0

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)