A0JV95 (MURC_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8

Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	Arth_1571

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00046
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm By similarity HAMAP MF_00046.
Sequence similarities	Belongs to the MurCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_0000336813
Regions
	Nucleotide binding	123 – 129	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A0JV95 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 160A537130BAB953	FASTA	467	47,584
	10 20 30 40 50 60 MTMSTARTAV RSLESLGRVH FIGIGGVGMS AVARIMVARG VPVTGSDAKD LPVMADLAAA 70 80 90 100 110 120 GAGIHVGYSA GNLGAAEAVV AGSAIRADNP ELQAARAAGL PVLHRSEALA AAMAGDRVVT 130 140 150 160 170 180 VAGTHGKSTT TSMVTVLLQG AGLDPTFAIG ANVPSLGVNA ASGTSDIFVA EADESDGSFL 190 200 210 220 230 240 NYRPHIAVVT NVEPDHLDYY GTAEAVYESF DSFTELLPAD GVLVACADDP GARALAERTR 250 260 270 280 290 300 TRGNTRVVTY GTAEDAQLRL HDGGPGDVWV STGAGRFALD LQVPGRHNAL NAAAAFAVAL 310 320 330 340 350 360 ELGVAPDAAS GALAHFSGAS RRFEFKGEGR GVRVYDDYAH HPTEVRAALA AARSVAGDHK 370 380 390 400 410 420 VHVLFQPHLF SRTREFAADF AEALNAADTA LVLDIYPARE DPIPGVSSKL IGDRLSAGGR 430 440 450 460 LVAAEDAVRA VVANAAAGDI VLTAGAGDVT AYGPLIVEAL LAEAPGG

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK02965.1.
RefSeq	YP_831065.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JV95.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JV95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4445903.
GenomeReviews	Gene locus Arth_1571 in contig CP000454_GR.
KEGG	art:Arth_1571.
PATRIC	20998451. VBIArtSp72239_1931.
TIGR	Arth_1571.
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HBG476594.
OMA	YQPHRYS.
PhylomeDB	A0JV95.
ProtClustDB	PRK00421.
Enzyme and pathway databases
BioCyc	ASP1667:ARTH_1571-MONOMER.
Family and domain databases
HAMAP	MF_00046. MurC. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K01924.
PANTHER	PTHR23135:SF5. PTHR23135:SF5. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01082. MurC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_ARTS2

Accession

Primary (citable) accession number: A0JV95

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program