Reviewed, UniProtKB/Swiss-Prot A0JV91 (MRAY_ARTS2)

Names and origin

Protein names

Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase

Gene names

Name:	mraY
Ordered Locus Names:	Arth_1567

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.
Catalytic activity	UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 4 family. MraY subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	phospho-N-acetylmuramoyl-pentapeptide-transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038		PRO_1000002935
Regions
	Transmembrane	2 – 22	21	Potential
	Transmembrane	55 – 75	21	Potential
	Transmembrane	86 – 106	21	Potential
	Transmembrane	122 – 142	21	Potential
	Transmembrane	158 – 178	21	Potential
	Transmembrane	196 – 216	21	Potential
	Transmembrane	239 – 259	21	Potential
	Transmembrane	266 – 286	21	Potential
	Transmembrane	291 – 311	21	Potential
	Transmembrane	348 – 368	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A0JV91-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 8E3A4EF8625CC526	FASTA	369	39,203
	10 20 30 40 50 60 MIALLIGAGL ALLFALVGTP LFIRLLVRKS YGQFIRDDGP TSHHTKRGTP TMGGTVVVFA 70 80 90 100 110 120 VLLSYALTHL IMWMMNPRSP GPSASALLLL FLMVGMGLVG FLDDFIKISK QRSLGLDAKA 130 140 150 160 170 180 KLVLQGAVGI IFAILALNFP NADGVTPAST QISLVRDIPW LNLAFGGTVL GAILFVLWSN 190 200 210 220 230 240 LIVTAATNGV NLTDGLDGLA AGASVMVFGA YTLMGIWQSN QACGSPRQTG GGCYSVRDPL 250 260 270 280 290 300 DLALLAAILS AALVGFLWWN TSPAKIFMGD TGSLAIGGAV AGFAILSRTE LLLAFIGGLF 310 320 330 340 350 360 VLITLSVIIQ VGYFKITKGK RFFKMAPLQH HFELKGWAEV TVVVRFWILG GLFVAAGLGI FYAEWVVLL

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK02961.1.
RefSeq	YP_831061.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0JV91.
Genome annotation databases
GeneID	4445899.
GenomeReviews	Gene locus Arth_1567 in contig CP000454_GR.
KEGG	art:Arth_1567.
TIGR	Arth_1567.
Phylogenomic databases
OMA	HHHFEQK.
Family and domain databases
HAMAP	MF_00038. [Tree]
InterPro	IPR000715. Glycosyl_transferase_4. IPR018481. Glycosyl_Trfase_4_cons-reg. IPR003524. PNAcMuramoyl-5peptid_Trfase. IPR018480. PNAcMuramoyl-5peptid_Trfase_CS. [Graphical view]
PANTHER	PTHR22926. Glyco_trans_4. 1 hit. PTHR22926:SF3. PNAcPpept_trans. 1 hit.
Pfam	PF00953. Glycos_transf_4. 1 hit. PF10555. MraY_sig1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00445. mraY. 1 hit.
PROSITE	PS01347. MRAY_1. False negative. PS01348. MRAY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRAY_ARTS2

Accession

Primary (citable) accession number: A0JV91

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)