Reviewed, UniProtKB/Swiss-Prot A0JV22 (ARGB_ARTS2)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	Arth_1498

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Acetylglutamate kinase HAMAP MF_00082		PRO_0000335607
Regions
	Region	74 – 75	2	Substrate binding By similarity
Sites
	Binding site	96	1	Substrate By similarity
	Binding site	201	1	Substrate By similarity
	Site	39	1	Transition state stabilizer By similarity
	Site	262	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JV22-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 71D67791F3090BC3	FASTA	310	32,486
	10 20 30 40 50 60 MNTQTRETTS MSDAQDKAGT LIEALPWIQR FAGTTMVIKY GGNAMVNDEL RRAFAEDVVF 70 80 90 100 110 120 LHHVGIHPVV VHGGGPQINA MLSRLGIESE FKGGLRVTTP EAMDVVRMVL TGQVGRELVG 130 140 150 160 170 180 LINSHGPYAV GMSGEDGGLL RAVRTGTVVD GEEVDLGLVG EVVGVNPEGI VDILAAGRIP 190 200 210 220 230 240 VISTVAPEIA DDGSTTGQVL NVNADTAAAA VASALGASKL VILTDVEGLY ANWPDKSSLI 250 260 270 280 290 300 SSLTASELRE MLPRLESGMI PKMAACLQAV DDGVERAHIV DGRLPHSMLL ETFTTAGIGT 310 QVVPDEETNA

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK02892.1.
RefSeq	YP_830992.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0JV22.
Genome annotation databases
GeneID	4445994.
GenomeReviews	Gene locus Arth_1498 in contig CP000454_GR.
KEGG	art:Arth_1498.
TIGR	Arth_1498.
Phylogenomic databases
OMA	FVIKYGG.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ARTS2

Accession

Primary (citable) accession number: A0JV22

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)