Reviewed, UniProtKB/Swiss-Prot A0JUI7 (HUTI_ARTS2)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Arth_1313

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Imidazolonepropionase HAMAP MF_00372		PRO_0000306426
Sites
	Metal binding	64	1	Zinc or iron By similarity
	Metal binding	66	1	Zinc or iron By similarity
	Metal binding	219	1	Zinc or iron By similarity
	Metal binding	303	1	Zinc or iron By similarity
	Binding site	73	1	Substrate By similarity
	Binding site	86	1	Substrate By similarity
	Binding site	131	1	Substrate By similarity
	Binding site	158	1	Substrate By similarity
	Binding site	222	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JUI7-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 4626C3E7F1919D60	FASTA	400	41,829
	10 20 30 40 50 60 MSTLITNIAE LMTQDAEHRV LKDAAVVIEG ERISWIGPSS AAPAADDEVD AGGRALLPGW 70 80 90 100 110 120 VDSHTHLIFA GDRTAEFEAR MAGESYSAGG IAVTTGATRG TSDFDLTRLA LGRVAEAVSQ 130 140 150 160 170 180 GTTYLETKTG YGLDVENETR SARIASTVAD EVTYLGAHLV PAGADADEYT DLVCGPMLAA 190 200 210 220 230 240 VRPYVSWADV FCEQGAFNEQ QSRRVLQACK DAGMGLRVHG NQLGEGPGVR LAVEFGAASV 250 260 270 280 290 300 DHVNYLSAAD VEALAGSWSG WQGAGTRGTV ATCLPACDLS TRQPLAPGRE LLDAGVPIAL 310 320 330 340 350 360 ASNCNPGTSY TSSMAFCVTT AVLQMRLSVH EAVRAATYGG ALALRREAGN DVDGERAVGS 370 380 390 400 VAIGHRADLH LLNAPSATHL AYRPGIPLTH AVWRAGVRAR

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000454 Genomic DNA. Translation: ABK02707.1.
RefSeq	YP_830807.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0JUI7.
Genome annotation databases
GeneID	4446202.
GenomeReviews	Gene locus Arth_1313 in contig CP000454_GR.
KEGG	art:Arth_1313.
TIGR	Arth_1313.
Phylogenomic databases
OMA	MNMACTL.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_ARTS2

Accession

Primary (citable) accession number: A0JUI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)