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Protein

Alanine racemase

Gene

Arth_1108

Organism
Arthrobacter sp. (strain FB24)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Arth_1108), Alanine racemase (Arth_2896)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Active sitei281Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei329Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciASP290399:GHIF-1128-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Arth_1108Imported
OrganismiArthrobacter sp. (strain FB24)Imported
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000000754 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi290399.Arth_1108

Structurei

3D structure databases

ProteinModelPortaliA0JTY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 389Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0JTY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNAHIESA RNAALTGQVS VDLSAISDNI RTLRQRSAAP HFMAVVKGNA
60 70 80 90 100
YGHGLVDVAR TALSAGADWL GTAQLHEAIA LRRAGITAPV LSWLYLAAAS
110 120 130 140 150
SETIREALEY DVDVSLGSVA QLDVVAGIAR RLGRPAVVHL ELDTGLSRGG
160 170 180 190 200
ARAEDWAELV AAARTAERDG TLSVRGVWTH LAWADVPAHP ANLAAVAAFE
210 220 230 240 250
EAVLAARAAG LEPELRHVSS SANILDRPEF AFDMVRAGLA FYGLAPADHL
260 270 280 290 300
APADFGLRPA LTVTAPVVLV KKVPAGTGVS YEHQAITHEP RYLGLIPLGY
310 320 330 340 350
ADGIPKGISG RSLILLGGRR VPVIGKVCMD QFMVDLGPDA NGVAVGDTAV
360 370 380 390 400
LFGDPRTGAA SADDWGAAIG SHGDEIINRI APRLPRAYEC PDYQEAGAPV

GA
Length:402
Mass (Da):42,040
Last modified:December 12, 2006 - v1
Checksum:i538B48B3E9112BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA Translation: ABK02502.1

Genome annotation databases

EnsemblBacteriaiABK02502; ABK02502; Arth_1108
KEGGiart:Arth_1108

Similar proteinsi

Entry informationi

Entry nameiA0JTY2_ARTS2
AccessioniPrimary (citable) accession number: A0JTY2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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