A0JT53 (IOLG_ARTS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Arth_0825

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP]

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352553

Sequences

	Sequence		Length	Mass (Da)
	A0JT53 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: E76AE8247C7EC538	FASTA	337	36,178
	10 20 30 40 50 60 MTETLRVAVI GAGRMGADHI QRLSKRIHGA EVAAVVDVDL ARAQAAVEGI PGAVALADAD 70 80 90 100 110 120 EALNNGDVNA VLIATPGFLH EDILLKALAR DIPILCEKPL TPDAESAWKI VQAEEKLGHK 130 140 150 160 170 180 RIQVGFMRRF DAEYAALGQV IRDHELGELL MLHHQHRNPT TPPGFTNEML INDSVVHEFD 190 200 210 220 230 240 AIRFFTGEEI TSVQVRLGKA TKNAPAGQHD PQHVLVETES GVLADVEIFV NAKFGYEVAT 250 260 270 280 290 300 QASFEDGIVS IGGDKGPYTR AAGRWGGNVT PGFEERFGAA YDVEIQSWVD AALRGEIGGP 310 320 330 TAWDGYATAA CCEAGVEAQK NGEKVAVKLN ARPALYS

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK02223.1.
RefSeq	YP_830323.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JT53.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JT53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4446663.
GenomeReviews	Gene locus Arth_0825 in contig CP000454_GR.
KEGG	art:Arth_0825.
PATRIC	20996907. VBIArtSp72239_1171.
TIGR	Arth_0825.
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	RTEVVGE.
ProtClustDB	CLSK959549.
Enzyme and pathway databases
BioCyc	ASP1667:ARTH_0825-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_ARTS2

Accession

Primary (citable) accession number: A0JT53

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program