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A0JSP6

- PCKG_ARTS2

UniProt

A0JSP6 - PCKG_ARTS2

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, Arth_0667
Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei224 – 2241Substrate; via amide nitrogen By similarity
Metal bindingi231 – 2311Manganese By similarity
Binding sitei231 – 2311Substrate By similarity
Metal bindingi251 – 2511Manganese; via tele nitrogen By similarity
Binding sitei273 – 2731Substrate By similarity
Active sitei275 – 2751 By similarity
Metal bindingi298 – 2981Manganese By similarity
Binding sitei391 – 3911GTP By similarity
Binding sitei422 – 4221GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2796GTP By similarity
Nucleotide bindingi517 – 5204GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP290399:GHIF-682-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:Arth_0667
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_1000072370Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_0667.

Structurei

3D structure databases

ProteinModelPortaliA0JSP6.
SMRiA0JSP6. Positions 13-608.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni389 – 3913Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiIDWHGND.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JSP6-1 [UniParc]FASTAAdd to Basket

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MGDLARLPLL EKAPTTHAGL LAWVEEVAEL TQPDRIHWVD GTEEEYTRLT    50
GELVEAGTLT RLNPELFPNS FAAFSDPADV ARVEEQTFIC SENQRDAGFT 100
NNWMAPAEMK QKLRGLFAGS MRGRTMYVIP FVMGHLDAED PKFGVEITDS 150
AYVVASMRIM ANIGTEVLDK ITATNAFFVP ALHSLGAPLA PGQADVAWPC 200
NPDKWIVHFP EERSIWSFGS GYGGNALLGK KCYALRIASV MARDEGWLAE 250
HMLILKLTSP EKKSYYMSAA FPSACGKTNL ALLDPTIEGW EVETLGDDIT 300
WMRIGKEGEL RATNPEAGLF GVAPGTGWGT NPNAMRAIAK GHSIFTNVAL 350
TDDGGVWWEG MTEETPAHLT DWQGNSWTPD SDKPAAHPNS RFCTPISQID 400
MLAEEYYSPE GVELSAILFG GRRKTTVPLV TQARSWTNGI FMGSTLSSET 450
TAAAAGQVGV LRRDPMAMLP FIGYDAGDYL KHWISVSGKA NPERLPHIFL 500
VNWFRRTADG DFAWPGFGDN ARVLKWAIER IEGKADAIET PIGFVPAGHA 550
LDLTGLDLTH AHVEDAVRVD REEWDAELAS IEEWYAKFGD SLPEALRAEL 600
DALKERMADH S 611
Length:611
Mass (Da):67,176
Last modified:December 12, 2006 - v1
Checksum:i13FC3189846C263D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK02066.1.
RefSeqiWP_011690534.1. NC_008541.1.
YP_830166.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK02066; ABK02066; Arth_0667.
GeneIDi4446848.
KEGGiart:Arth_0667.
PATRICi20996579. VBIArtSp72239_1015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK02066.1 .
RefSeqi WP_011690534.1. NC_008541.1.
YP_830166.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0JSP6.
SMRi A0JSP6. Positions 13-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_0667.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK02066 ; ABK02066 ; Arth_0667 .
GeneIDi 4446848.
KEGGi art:Arth_0667.
PATRICi 20996579. VBIArtSp72239_1015.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi IDWHGND.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci ASP290399:GHIF-682-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiPCKG_ARTS2
AccessioniPrimary (citable) accession number: A0JSP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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