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A0JSP6

- PCKG_ARTS2

UniProt

A0JSP6 - PCKG_ARTS2

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821SubstrateUniRule annotation
    Binding sitei224 – 2241Substrate; via amide nitrogenUniRule annotation
    Metal bindingi231 – 2311ManganeseUniRule annotation
    Binding sitei231 – 2311SubstrateUniRule annotation
    Metal bindingi251 – 2511Manganese; via tele nitrogenUniRule annotation
    Binding sitei273 – 2731SubstrateUniRule annotation
    Active sitei275 – 2751UniRule annotation
    Metal bindingi298 – 2981ManganeseUniRule annotation
    Binding sitei391 – 3911GTPUniRule annotation
    Binding sitei422 – 4221GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi274 – 2796GTPUniRule annotation
    Nucleotide bindingi517 – 5204GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASP290399:GHIF-682-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:Arth_0667
    OrganismiArthrobacter sp. (strain FB24)
    Taxonomic identifieri290399 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000754: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 611611Phosphoenolpyruvate carboxykinase [GTP]PRO_1000072370Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290399.Arth_0667.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JSP6.
    SMRiA0JSP6. Positions 13-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni389 – 3913Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiIDWHGND.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JSP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDLARLPLL EKAPTTHAGL LAWVEEVAEL TQPDRIHWVD GTEEEYTRLT    50
    GELVEAGTLT RLNPELFPNS FAAFSDPADV ARVEEQTFIC SENQRDAGFT 100
    NNWMAPAEMK QKLRGLFAGS MRGRTMYVIP FVMGHLDAED PKFGVEITDS 150
    AYVVASMRIM ANIGTEVLDK ITATNAFFVP ALHSLGAPLA PGQADVAWPC 200
    NPDKWIVHFP EERSIWSFGS GYGGNALLGK KCYALRIASV MARDEGWLAE 250
    HMLILKLTSP EKKSYYMSAA FPSACGKTNL ALLDPTIEGW EVETLGDDIT 300
    WMRIGKEGEL RATNPEAGLF GVAPGTGWGT NPNAMRAIAK GHSIFTNVAL 350
    TDDGGVWWEG MTEETPAHLT DWQGNSWTPD SDKPAAHPNS RFCTPISQID 400
    MLAEEYYSPE GVELSAILFG GRRKTTVPLV TQARSWTNGI FMGSTLSSET 450
    TAAAAGQVGV LRRDPMAMLP FIGYDAGDYL KHWISVSGKA NPERLPHIFL 500
    VNWFRRTADG DFAWPGFGDN ARVLKWAIER IEGKADAIET PIGFVPAGHA 550
    LDLTGLDLTH AHVEDAVRVD REEWDAELAS IEEWYAKFGD SLPEALRAEL 600
    DALKERMADH S 611
    Length:611
    Mass (Da):67,176
    Last modified:December 12, 2006 - v1
    Checksum:i13FC3189846C263D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK02066.1.
    RefSeqiWP_011690534.1. NC_008541.1.
    YP_830166.1. NC_008541.1.

    Genome annotation databases

    EnsemblBacteriaiABK02066; ABK02066; Arth_0667.
    GeneIDi4446848.
    KEGGiart:Arth_0667.
    PATRICi20996579. VBIArtSp72239_1015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000454 Genomic DNA. Translation: ABK02066.1 .
    RefSeqi WP_011690534.1. NC_008541.1.
    YP_830166.1. NC_008541.1.

    3D structure databases

    ProteinModelPortali A0JSP6.
    SMRi A0JSP6. Positions 13-608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290399.Arth_0667.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK02066 ; ABK02066 ; Arth_0667 .
    GeneIDi 4446848.
    KEGGi art:Arth_0667.
    PATRICi 20996579. VBIArtSp72239_1015.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi IDWHGND.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci ASP290399:GHIF-682-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FB24.

    Entry informationi

    Entry nameiPCKG_ARTS2
    AccessioniPrimary (citable) accession number: A0JSP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3