ID   A0JSC2_ARTS2            Unreviewed;      1015 AA.
AC   A0JSC2;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Arth_0543 {ECO:0000313|EMBL:ABK01942.1};
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK01942.1, ECO:0000313|Proteomes:UP000000754};
RN   [1] {ECO:0000313|Proteomes:UP000000754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FB24 {ECO:0000313|Proteomes:UP000000754};
RX   PubMed=24501649; DOI=10.4056/sigs.4438185;
RA   Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA   Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT   "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL   Stand. Genomic Sci. 9:106-116(2013).
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DR   EMBL; CP000454; ABK01942.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0JSC2; -.
DR   STRING; 290399.Arth_0543; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; art:Arth_0543; -.
DR   eggNOG; COG1470; Bacteria.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_299110_0_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000000754; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ABK01942.1};
KW   Hydrolase {ECO:0000313|EMBL:ABK01942.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000754};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          107..426
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   DOMAIN          462..523
FT                   /note="Alpha-galactosidase NEW3"
FT                   /evidence="ECO:0000259|Pfam:PF10633"
SQ   SEQUENCE   1015 AA;  106055 MW;  176400292F8E9E39 CRC64;
     MWDKSLCPTR FRTAALGRLP ERTVDLKLKK REPAGRAGSV GRVAAAGLLG MALIAGPGLP
     ARAEPAPPSN PAAAPGTFAE ANIAADRTAA NFFYRIPALT YLGNDVVLAA WDGRPGSSAD
     APNPNSIVQR RSIDGGATWG PLTVIAAGHV ADASGPKYGF SDPSYIYDAE ANKVFALFVY
     SKDAGFSAST YGNDDADRNV ISSAVVESAD EGRTWSQPRF ITSVTKPGSS KTNPQPGDVR
     TNFAASGEGI QLKYGAHKGR LIQQYSGYVR QANGSELFQA YSVYSDDHGA TWHKGAPIGD
     RMDENKTVEL SDGRVLLNSR DSGNGGYRKV AVSTDGGASY GPVTQDTELP DPANNGSISR
     MYPAAPEGSA EARKLIFTNS NSKAARENVS ARVSCDDGAT WPGVRTIRPG FSAYSTITRL
     AEGKFGVLYE ANYTDNIQFA SFDDAWLNYV CAPVNVPAQT IAPGVAQQVP VTVTNQEAHV
     LSGARASIYT PAGWSAATVD VPDLATGSSA TVNVQLTPPA GASGPTSLNA AFTTADGRVS
     QYTFVANSPV APQVGLTIAG SAPARDVAAN PYKEGEVLSY TFAVKSTSNV TSNAVPLSGT
     FETGFLPPSA PNCRYNNLAA GASYNCTTPK HTLTPEDIAR GYLVPVAEFT VTASGNTALT
     KAVSFKGAAV PLRDGLLAGS ISGARNDAGR DLAVQPYAAG EQVPYTFTVS NTGPLAADVV
     PIAGNFSPLV PPGAGNCRWL NLAAGGSYAC STPRHTVTQK EAEEGFFRAD STWTVAASGQ
     SSREYRVDGG EVDLAIRNPK LDGTISAEWA DADGDRYASA GDSVTYTYGV GNAGNVALTG
     VTATDAGISV DRLGIGETAT ATRVHILTPA DIAAGQLPAS PFAASASNGS RNVRVDVQAG
     AVALRLQPAK PAAVPVLTVQ DFDGQVPPVD LDTNEKYRNG EKVTLRGLPH GQWYYVYLNK
     HGFRLGWIFP TTADTVEFLL PSTVQNGRDD VVVLDSEGKQ VSFDRLQVTP KGSIG
//