ID A0JRM5_ARTS2 Unreviewed; 845 AA. AC A0JRM5; DT 12-DEC-2006, integrated into UniProtKB/TrEMBL. DT 12-DEC-2006, sequence version 1. DT 27-MAR-2024, entry version 98. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=Arth_0294 {ECO:0000313|EMBL:ABK01695.1}; OS Arthrobacter sp. (strain FB24). OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae; OC Arthrobacter. OX NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK01695.1, ECO:0000313|Proteomes:UP000000754}; RN [1] {ECO:0000313|Proteomes:UP000000754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FB24 {ECO:0000313|Proteomes:UP000000754}; RX PubMed=24501649; DOI=10.4056/sigs.4438185; RA Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T., RA Han C., Beasley F., Chen W., Konopka A., Xie G.; RT "Complete genome sequence of Arthrobacter sp. strain FB24."; RL Stand. Genomic Sci. 9:106-116(2013). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000454; ABK01695.1; -; Genomic_DNA. DR RefSeq; WP_011690165.1; NC_008541.1. DR AlphaFoldDB; A0JRM5; -. DR STRING; 290399.Arth_0294; -. DR KEGG; art:Arth_0294; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_2_1_11; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000000754; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd04863; MtLigD_Pol_like; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR033649; MtLigD_Pol-like. DR InterPro; IPR012340; NA-bd_OB-fold. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS00697; DNA_LIGASE_A1; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABK01695.1}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000000754}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 630..754 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 287..354 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 497..526 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 325..345 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 845 AA; 92365 MW; 5FE4487128634C0A CRC64; MAGSRERVRI QGRELVVTNL DKVMYPETGT TKADVLAYYT AVAPVLVPAA VNRPATRKRW VNGVGTAEAP GEMFFQKNLE DSTPGWIPRA SIRHKERTNQ YPLVNDAATL IWLAQMGSLE IHVPQWRVDP HGNPMNPDRL VLDLDPGEGA GLAECAEVAR LARAILRDVG LDPIPVTSGS KGVHLYAGLD GTQSSDQISE FAHELARALE SDHPDLAVSD MKKTLRTGKV LVDWSQNNAA KTTIVPYSLR GRLRPTVAAP RTWRELASPK LKQLDYREVM RRVKDGKDPF APVSAGGSHV RGHPGGGGSA AGPRDSTTAD GGSTDPRLEK YRSMRDPEGT PEPFSADRHG ADPNAGTIRE RFVIQEHHAS RLHYDFRLER DGVLVSWALP KGVPTSGTQN HLAVQTEDHP MDYLDFEGTI PKGQYGAGNV TIWDHGYYEC DKWIAGKEVI ATLTGADGGG LGGTRKFALI RTSRDSDTSK SPEQAQWLIH LMDRKGHAPA ATGTPPATGG PAEAAKQDEP PPDLSPAPDF LPMMASAGTP ADLRGLDWQF ELKWDGIRAL IIGDADRIRL ISRNGNDMTA SYPELTDRSC WPEQSFTADG EIVAVGPSGR PDFGLLQTRM KLTKAADVAK ARAATPVRLM VFDLLSDAGE DLRRMPLRRR RARLEQLDWP DGCPVHLSEV LDHEVEHILE SARELGLEGI MAKRLDGRYV SGERSRSWLK LKFERTQEVV VGGWRPGKGS RQGSVGSLLV GIPDGAKLRY VGRVGSGFSD RELKELRLQV DTLSRKTSPF TEVPAADASD AHWVAPGLVG EVTFGEWTGG GKLRHPVWRG WRLDKNADDV VAESG //