ID   A0JRC0_ARTS2            Unreviewed;       589 AA.
AC   A0JRC0;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Arth_0189 {ECO:0000313|EMBL:ABK01590.1};
OS   Arthrobacter sp. (strain FB24).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=290399 {ECO:0000313|EMBL:ABK01590.1, ECO:0000313|Proteomes:UP000000754};
RN   [1] {ECO:0000313|Proteomes:UP000000754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FB24 {ECO:0000313|Proteomes:UP000000754};
RX   PubMed=24501649; DOI=10.4056/sigs.4438185;
RA   Nakatsu C.H., Barabote R., Thompson S., Bruce D., Detter C., Brettin T.,
RA   Han C., Beasley F., Chen W., Konopka A., Xie G.;
RT   "Complete genome sequence of Arthrobacter sp. strain FB24.";
RL   Stand. Genomic Sci. 9:106-116(2013).
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DR   EMBL; CP000454; ABK01590.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0JRC0; -.
DR   STRING; 290399.Arth_0189; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; art:Arth_0189; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_493195_0_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000000754; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ABK01590.1};
KW   Hydrolase {ECO:0000313|EMBL:ABK01590.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000754};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          45..365
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          392..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   589 AA;  62397 MW;  5580043D7D1A65DE CRC64;
     MTSHLFSSAD GIPMARPATE HVLAERGRGG YRQYRIPAMA VTARGTLLAA YDGRPNLDDL
     PSPIDLLLRR SGDSGRSWQA QQVVRTGVGL EGYGDPSLLV DAETGRIFMF HAAGTRAGFF
     EAAEGAGNDG DVQHCDVSYS DDDGLTWRHR RLTDQLKLAA GRGRGITGIF AAAGQGIQIH
     AGPFSGRLVQ QYVVLVQGNI LAASAYSDDH GETWTLGEFI GPSTAGGEAG APTAGEAAPN
     ENKVACLNDG RLLLHSRATP RRLSALSGDG GHSWSPLTAI ADLPDPSDNG SVTRFDGLPL
     PLGHATAETD AWVLATNNHD TALRRNTVLS LSRDNGASWP AKLVICPGSS AYSTAARLPD
     GNIGVLYERQ GYREIVFCSI PPAQLTDAAA LRQGNRRDAR QDSARPDQPS GRASGPPASG
     MVFDMELRSI TPGRPEVWQN AGEFHVLAAD AGQWDVHTWK EIGQGYSPES AQVVGTREAQ
     DLNYGPVSTG YKAGDILAFT GRARNSGPEV LAGVRLTGPG AEEFGPADLQ PGEESLYFTP
     VCTVTAQDVG RGSLDVRYGV EWTAAGVNGR LERRFTFNMA DGSVDIGPV
//