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A0JR91

- PANC_ARTS2

UniProt

A0JR91 - PANC_ARTS2

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Protein

Pantothenate synthetase

Gene

panC

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton donorUniRule annotation
Binding sitei60 – 601Beta-alanineUniRule annotation
Binding sitei60 – 601PantoateUniRule annotation
Binding sitei173 – 1731PantoateUniRule annotation
Binding sitei196 – 1961ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 368ATPUniRule annotation
Nucleotide bindingi167 – 1704ATPUniRule annotation
Nucleotide bindingi204 – 2074ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP290399:GHIF-165-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Arth_0160
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000754: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Pantothenate synthetasePRO_0000305393Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_0160.

Structurei

3D structure databases

ProteinModelPortaliA0JR91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JR91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTAAQLRAE SARLLTEKQG SSQGLVPTMG ALHEGHARLA RTAVEQNDVV
60 70 80 90 100
VASIFVNPLQ FGEAVDLDRY PRTLEADMEL LDAEGVDLVF APAVEEVYPG
110 120 130 140 150
GEPLVRVTAG RLAGKWEGAS RPGHFDGALT VVAKLLHYGI PGTGLPGGGA
160 170 180 190 200
FVTGAGAGLP AYRAYFGQKD AQQLTLVRRM VTDLNFPVEI VAVPTVRSAD
210 220 230 240 250
GLALSSRNRF LSGEEREAAL VLSRALRLLE ERANAHEPLD LESAQALVES
260 270 280 290 300
QPLVGLDYFD VVDPETLEPL AENCKETPFR GEGLAIIAAK VGPVRLIDNL

PLSS
Length:304
Mass (Da):32,382
Last modified:December 12, 2006 - v1
Checksum:i15D698482BC97990
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK01561.1.
RefSeqiWP_011690031.1. NC_008541.1.
YP_829661.1. NC_008541.1.

Genome annotation databases

EnsemblBacteriaiABK01561; ABK01561; Arth_0160.
GeneIDi4447388.
KEGGiart:Arth_0160.
PATRICi20995549. VBIArtSp72239_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000454 Genomic DNA. Translation: ABK01561.1 .
RefSeqi WP_011690031.1. NC_008541.1.
YP_829661.1. NC_008541.1.

3D structure databases

ProteinModelPortali A0JR91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290399.Arth_0160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK01561 ; ABK01561 ; Arth_0160 .
GeneIDi 4447388.
KEGGi art:Arth_0160.
PATRICi 20995549. VBIArtSp72239_0507.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci ASP290399:GHIF-165-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FB24.

Entry informationi

Entry nameiPANC_ARTS2
AccessioniPrimary (citable) accession number: A0JR91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3