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Protein

Pantothenate synthetase

Gene

panC

Organism
Arthrobacter sp. (strain FB24)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36Proton donorUniRule annotation1
Binding sitei60Beta-alanineUniRule annotation1
Binding sitei60PantoateUniRule annotation1
Binding sitei173PantoateUniRule annotation1
Binding sitei196ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 36ATPUniRule annotation8
Nucleotide bindingi167 – 170ATPUniRule annotation4
Nucleotide bindingi204 – 207ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Arth_0160
OrganismiArthrobacter sp. (strain FB24)
Taxonomic identifieri290399 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
Proteomesi
  • UP000000754 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003053931 – 304Pantothenate synthetaseAdd BLAST304

Proteomic databases

PRIDEiA0JR91

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290399.Arth_0160

Structurei

3D structure databases

ProteinModelPortaliA0JR91
SMRiA0JR91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 2 hits
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 2 hits

Sequencei

Sequence statusi: Complete.

A0JR91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAAQLRAE SARLLTEKQG SSQGLVPTMG ALHEGHARLA RTAVEQNDVV
60 70 80 90 100
VASIFVNPLQ FGEAVDLDRY PRTLEADMEL LDAEGVDLVF APAVEEVYPG
110 120 130 140 150
GEPLVRVTAG RLAGKWEGAS RPGHFDGALT VVAKLLHYGI PGTGLPGGGA
160 170 180 190 200
FVTGAGAGLP AYRAYFGQKD AQQLTLVRRM VTDLNFPVEI VAVPTVRSAD
210 220 230 240 250
GLALSSRNRF LSGEEREAAL VLSRALRLLE ERANAHEPLD LESAQALVES
260 270 280 290 300
QPLVGLDYFD VVDPETLEPL AENCKETPFR GEGLAIIAAK VGPVRLIDNL

PLSS
Length:304
Mass (Da):32,382
Last modified:December 12, 2006 - v1
Checksum:i15D698482BC97990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000454 Genomic DNA Translation: ABK01561.1

Genome annotation databases

EnsemblBacteriaiABK01561; ABK01561; Arth_0160
KEGGiart:Arth_0160

Similar proteinsi

Entry informationi

Entry nameiPANC_ARTS2
AccessioniPrimary (citable) accession number: A0JR91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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