A0JQT2 (A0JQT2_ARTS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377
Ordered Locus Names:	Arth_0001

Organism

Arthrobacter sp. (strain FB24) [Complete proteome] [HAMAP] EMBL ABK01402.1

Taxonomic identifier

290399 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 DNA-binding HAMAP MF_00377 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	173 – 180	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	A0JQT2 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 854F6BF182B1FE09	FASTA	474	53,201
	10 20 30 40 50 60 MMTVDEANHA NTVGSSWRRV VSLLEQDHRV SPRQRGFVIL AQAQGLIGST LLVAVPNELT 70 80 90 100 110 120 REVLQTQVKE ALDDALHNVF SDDIRCAIDV DTDLVPVHTE PEPAVELSLA TDPTVELKPQ 130 140 150 160 170 180 PMLPSTSHEF GRLNPKYVFD TFVIGSSNRF AHAAAVAVAE APAKAYNPLF IYGDSGLGKT 190 200 210 220 230 240 HLLHAIGHYA RRLYSGIRVR YVNSEEFTND FINSIRDDEG TSFKTTYRNV DVLLIDDIQF 250 260 270 280 290 300 LAGKDRTLEE FFHTFNALHN NNKQVVITSD QPPKLLAGFE DRMKSRFEWG LLTDIQPPEL 310 320 330 340 350 360 ETRIAILRKK ALSEGLSAPD DALEYIASKI SSNIRELEGA LIRVTAFASL NRQPVDVALA 370 380 390 400 410 420 EMVLKDLITD DGAQEITSAQ ILTQTADYFK LSMEELCSKS RTRTLVTARQ IAMYLCRELT 430 440 450 460 470 DMSLPKIGQE LGGRDHTTVI HADRKIRELM AERRVIYNQV TELTNRIKQQ QRDS

References

[1]

"Complete sequence of chromosome 1 of Arthrobacter sp. FB24." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Thompson S., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Beasley F., Chen W., Jerke K., Nakatsu C.H., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FB24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000454 Genomic DNA. Translation: ABK01402.1.
RefSeq	YP_829502.1. NC_008541.1.
3D structure databases
ProteinModelPortal	A0JQT2.
ModBase	Search...
Protein-protein interaction databases
STRING	A0JQT2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4447534.
GenomeReviews	Gene locus Arth_0001 in contig CP000454_GR.
KEGG	art:Arth_0001.
PATRIC	20995213. VBIArtSp72239_0343.
TIGR	Arth_0001.
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	DEVAFLI.
PhylomeDB	A0JQT2.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0JQT2_ARTS2

Accession

Primary (citable) accession number: A0JQT2

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)