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Protein

Alkylglycerol monooxygenase

Gene

Agmo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity).By similarity

Catalytic activityi

1-alkyl-sn-glycerol + tetrahydrobiopterin + O2 = 1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O.

Cofactori

Fe cationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiR-RNO-75109. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkylglycerol monooxygenase (EC:1.14.16.5)
Alternative name(s):
Transmembrane protein 195
Gene namesi
Name:Agmo
Synonyms:Tmem195
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1312038. Agmo.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993021 – 447Alkylglycerol monooxygenaseAdd BLAST447

Proteomic databases

PaxDbiA0JPQ8.
PeptideAtlasiA0JPQ8.
PRIDEiA0JPQ8.

PTM databases

PhosphoSitePlusiA0JPQ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023116.
GenevisibleiA0JPQ8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029816.

Structurei

3D structure databases

ProteinModelPortaliA0JPQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 136Histidine box-15
Motifi145 – 149Histidine box-25
Motifi221 – 225Histidine box-35

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0872. Eukaryota.
COG3000. LUCA.
GeneTreeiENSGT00440000033807.
HOVERGENiHBG097659.
InParanoidiA0JPQ8.
KOiK15537.
OMAiYTMKPNE.
OrthoDBiEOG091G0P9T.
PhylomeDBiA0JPQ8.
TreeFamiTF314881.

Family and domain databases

InterProiIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamiPF04116. FA_hydroxylase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JPQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNPGAQDNV SVSQGMRAMF YMMKPSETAF QTVEEVPDYV KKATPFFIFL
60 70 80 90 100
ILLELVVSWI LKGKPSGRLD DILTSMSAGV VSRLPNLFFR SLEVTSYIYI
110 120 130 140 150
WENYRVCELP WDSPWTWYLT FLGVDFGYYW FHRMAHEINI IWAAHQAHHS
160 170 180 190 200
SEDYNLSTAL RQSVLQQYSS WVFYCPLALF VPPSVFAVHI QFNLLYQFWI
210 220 230 240 250
HTEVIRTLGP LELVLNTPSH HRVHHGRNRY CIDKNYAGTL IIWDRIFGTF
260 270 280 290 300
EAENEQVIYG LTHPIGTFEP FKVQFHHLLY IWTTFWATPG FCHKFSVLFK
310 320 330 340 350
GPGWGPGKPR LGLSEEIPEV TGQEVPFTSS ASQFLKIYAV LQFAVMLVFY
360 370 380 390 400
EETFANTAVL SQVTILLRIC FIILTLTSIG FLLDQRPKAA IVETLRCLLF
410 420 430 440
LTLYRFGHLK PLIESLSFAF EIFFSVCIAF WGVRSITHLA SGSWKKP
Length:447
Mass (Da):51,698
Last modified:December 12, 2006 - v1
Checksum:i5920D097F0D99EB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127545 mRNA. Translation: AAI27546.1.
RefSeqiNP_001129371.1. NM_001135899.1.
UniGeneiRn.152690.

Genome annotation databases

EnsembliENSRNOT00000032108; ENSRNOP00000029816; ENSRNOG00000023116.
GeneIDi362732.
KEGGirno:362732.
UCSCiRGD:1312038. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127545 mRNA. Translation: AAI27546.1.
RefSeqiNP_001129371.1. NM_001135899.1.
UniGeneiRn.152690.

3D structure databases

ProteinModelPortaliA0JPQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029816.

PTM databases

PhosphoSitePlusiA0JPQ8.

Proteomic databases

PaxDbiA0JPQ8.
PeptideAtlasiA0JPQ8.
PRIDEiA0JPQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032108; ENSRNOP00000029816; ENSRNOG00000023116.
GeneIDi362732.
KEGGirno:362732.
UCSCiRGD:1312038. rat.

Organism-specific databases

CTDi392636.
RGDi1312038. Agmo.

Phylogenomic databases

eggNOGiKOG0872. Eukaryota.
COG3000. LUCA.
GeneTreeiENSGT00440000033807.
HOVERGENiHBG097659.
InParanoidiA0JPQ8.
KOiK15537.
OMAiYTMKPNE.
OrthoDBiEOG091G0P9T.
PhylomeDBiA0JPQ8.
TreeFamiTF314881.

Enzyme and pathway databases

ReactomeiR-RNO-75109. Triglyceride Biosynthesis.

Miscellaneous databases

PROiA0JPQ8.

Gene expression databases

BgeeiENSRNOG00000023116.
GenevisibleiA0JPQ8. RN.

Family and domain databases

InterProiIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamiPF04116. FA_hydroxylase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALKMO_RAT
AccessioniPrimary (citable) accession number: A0JPQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.