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Protein

Dr1-associated corepressor

Gene

Drap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-1181150. Signaling by NODAL.
R-RNO-1502540. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Dr1-associated corepressor
Alternative name(s):
Dr1-associated protein 1
Negative cofactor 2-alpha
Short name:
NC2-alpha
Gene namesi
Name:Drap1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308477. Drap1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003116981 – 205Dr1-associated corepressorAdd BLAST205

Post-translational modificationi

Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JPP1.
PeptideAtlasiA0JPP1.
PRIDEiA0JPP1.

PTM databases

iPTMnetiA0JPP1.
PhosphoSitePlusiA0JPP1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020527.
GenevisibleiA0JPP1. RN.

Interactioni

Subunit structurei

Heterodimer with DR1. Binds BTAF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032674.

Structurei

3D structure databases

ProteinModelPortaliA0JPP1.
SMRiA0JPP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 77Histone-foldSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-LysSequence analysis4
Compositional biasi156 – 195Pro-richSequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the NC2 alpha/DRAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1659. Eukaryota.
COG5247. LUCA.
GeneTreeiENSGT00390000012424.
HOGENOMiHOG000113741.
HOVERGENiHBG051403.
InParanoidiA0JPP1.
KOiK21752.
OMAiHPPAHFQ.
OrthoDBiEOG091G0JIJ.
PhylomeDBiA0JPP1.
TreeFamiTF313964.

Family and domain databases

InterProiView protein in InterPro
IPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
PfamiView protein in Pfam
PF00808. CBFD_NFYB_HMF. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JPP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKKKKYNA RFPPARIKKI MQTDEEIGKV AAAVPVIISR ALELFLESLL
60 70 80 90 100
KKACQVTQSR NAKTMTTSHL KQCIELEQQF DFLKDLVASV PDMQGDGEDN
110 120 130 140 150
HTDGDKGPRR GRKPGSSGRK NGGTGSKSKD KKLSGTDSEQ EDESEDTDTD
160 170 180 190 200
GEEETPQAPP QASHPPAHFQ SPPTPFMPFT SPLPLPPAPP GPSAPEAEDE

EDYDS
Length:205
Mass (Da):22,326
Last modified:December 12, 2006 - v1
Checksum:iF84F24F0D18D8C87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127524 mRNA. Translation: AAI27525.1.
RefSeqiNP_001071136.1. NM_001077668.2.
UniGeneiRn.40582.

Genome annotation databases

EnsembliENSRNOT00000038138; ENSRNOP00000032674; ENSRNOG00000020527.
GeneIDi293674.
KEGGirno:293674.
UCSCiRGD:1308477. rat.

Similar proteinsi

Entry informationi

Entry nameiNC2A_RAT
AccessioniPrimary (citable) accession number: A0JPP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 12, 2006
Last modified: September 27, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families