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Protein

Dr1-associated corepressor

Gene

Drap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-1181150. Signaling by NODAL.
R-RNO-1502540. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Dr1-associated corepressor
Alternative name(s):
Dr1-associated protein 1
Negative cofactor 2-alpha
Short name:
NC2-alpha
Gene namesi
Name:Drap1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308477. Drap1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 205204Dr1-associated corepressorPRO_0000311698Add
BLAST

Post-translational modificationi

Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JPP1.
PRIDEiA0JPP1.

PTM databases

iPTMnetiA0JPP1.

Expressioni

Gene expression databases

GenevisibleiA0JPP1. RN.

Interactioni

Subunit structurei

Heterodimer with DR1. Binds BTAF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032674.

Structurei

3D structure databases

ProteinModelPortaliA0JPP1.
SMRiA0JPP1. Positions 10-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 7764Histone-foldSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 74Poly-LysSequence analysis
Compositional biasi156 – 19540Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the NC2 alpha/DRAP1 family.Curated
Contains 1 histone-fold domain.Sequence analysis

Phylogenomic databases

eggNOGiKOG1659. Eukaryota.
COG5247. LUCA.
GeneTreeiENSGT00390000012424.
HOGENOMiHOG000113741.
HOVERGENiHBG051403.
InParanoidiA0JPP1.
OMAiVPDMQGE.
OrthoDBiEOG7FBRJ0.
PhylomeDBiA0JPP1.
TreeFamiTF313964.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0JPP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKKKKYNA RFPPARIKKI MQTDEEIGKV AAAVPVIISR ALELFLESLL
60 70 80 90 100
KKACQVTQSR NAKTMTTSHL KQCIELEQQF DFLKDLVASV PDMQGDGEDN
110 120 130 140 150
HTDGDKGPRR GRKPGSSGRK NGGTGSKSKD KKLSGTDSEQ EDESEDTDTD
160 170 180 190 200
GEEETPQAPP QASHPPAHFQ SPPTPFMPFT SPLPLPPAPP GPSAPEAEDE

EDYDS
Length:205
Mass (Da):22,326
Last modified:December 12, 2006 - v1
Checksum:iF84F24F0D18D8C87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127524 mRNA. Translation: AAI27525.1.
RefSeqiNP_001071136.1. NM_001077668.2.
UniGeneiRn.40582.

Genome annotation databases

EnsembliENSRNOT00000038138; ENSRNOP00000032674; ENSRNOG00000020527.
GeneIDi293674.
KEGGirno:293674.
UCSCiRGD:1308477. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127524 mRNA. Translation: AAI27525.1.
RefSeqiNP_001071136.1. NM_001077668.2.
UniGeneiRn.40582.

3D structure databases

ProteinModelPortaliA0JPP1.
SMRiA0JPP1. Positions 10-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032674.

PTM databases

iPTMnetiA0JPP1.

Proteomic databases

PaxDbiA0JPP1.
PRIDEiA0JPP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038138; ENSRNOP00000032674; ENSRNOG00000020527.
GeneIDi293674.
KEGGirno:293674.
UCSCiRGD:1308477. rat.

Organism-specific databases

CTDi10589.
RGDi1308477. Drap1.

Phylogenomic databases

eggNOGiKOG1659. Eukaryota.
COG5247. LUCA.
GeneTreeiENSGT00390000012424.
HOGENOMiHOG000113741.
HOVERGENiHBG051403.
InParanoidiA0JPP1.
OMAiVPDMQGE.
OrthoDBiEOG7FBRJ0.
PhylomeDBiA0JPP1.
TreeFamiTF313964.

Enzyme and pathway databases

ReactomeiR-RNO-1181150. Signaling by NODAL.
R-RNO-1502540. Signaling by Activin.

Miscellaneous databases

PROiA0JPP1.

Gene expression databases

GenevisibleiA0JPP1. RN.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiNC2A_RAT
AccessioniPrimary (citable) accession number: A0JPP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 12, 2006
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.