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Protein

Zinc transporter ZIP4

Gene

Slc39a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP4
Alternative name(s):
Solute carrier family 39 member 4
Zrt- and Irt-like protein 4
Short name:
ZIP-4
Gene namesi
Name:Slc39a4Imported
Synonyms:Zip4By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306701. Slc39a4.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Recycling endosome membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 334313ExtracellularSequence analysisAdd
BLAST
Transmembranei335 – 35521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini356 – 37318CytoplasmicSequence analysisAdd
BLAST
Transmembranei374 – 39421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini395 – 41622ExtracellularSequence analysisAdd
BLAST
Transmembranei417 – 43721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini438 – 567130CytoplasmicSequence analysisAdd
BLAST
Transmembranei568 – 58821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini589 – 5968ExtracellularSequence analysis
Transmembranei597 – 61721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini618 – 6269CytoplasmicSequence analysis
Transmembranei627 – 64721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini648 – 6569ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 656635Zinc transporter ZIP4Sequence analysisPRO_0000278126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA0JPN2.
PRIDEiA0JPN2.

Expressioni

Gene expression databases

GenevisibleiA0JPN2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047376.

Family & Domainsi

Sequence similaritiesi

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
HOGENOMiHOG000293181.
HOVERGENiHBG062532.
InParanoidiA0JPN2.
KOiK14710.
OMAiFVFRQHS.
OrthoDBiEOG744T95.
PhylomeDBiA0JPN2.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0JPN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKSLTQGL LLAMLVGTAA MVQPYHLLSL LTSGQGALDR TALDGLLNTL
60 70 80 90 100
VARVHCTDGP CEKCLSVETA LALGKPDKPQ LAPESVLESR YITYLSAAAA
110 120 130 140 150
LYLNDPEKTC KDIRAGLLAS HVDDYLAKLE SPEAMTLGLS QLLQKIEAHD
160 170 180 190 200
ASQPTREETC VDVPQLLEEA EEAGVSRSPG LVLTALLDHV LNGSCFQGLP
210 220 230 240 250
SPQYFVDFVF RQLSSKPRNI TLPELEDLMH HLGVGGEDHS DHGDHVDHSH
260 270 280 290 300
LDREANHQDS ELHATHNSSS SVWDTLCLSA KDVMAVYGLS EEAGVSPQAW
310 320 330 340 350
AQLTPALVQQ QLSEACSSSP IIHVQDQLSQ AERYLYGSLA TLLICLCAVF
360 370 380 390 400
GLLLLTCAKC STATHYIMQT FLSLAVGALT GDALLHLIPK VLGLHTHSGE
410 420 430 440 450
VHSHEEESIG GQSTWRLLAV LGGFYIFFLF ESFFNLLLPR DQDHEKDGPC
460 470 480 490 500
SHGGHSHGIS LQLSPSNLRQ SKQPHESSRS DLVTEETPEL LNPDTRRLRA
510 520 530 540 550
ELRMLPYLIT LGDAVHNFAD GLAVGAAFSS TWKTGLATSL AVFCHELPHE
560 570 580 590 600
LGDFAALLHA GLTVKRALLL NLASALTAFA GLYVALAVGV GEEGETWILA
610 620 630 640 650
VATGLFLYVA LCDMLPAMMN VRDQRPWLLF LLHNVGLLGG WTILLLLSLY

EDSITF
Length:656
Mass (Da):71,121
Last modified:December 12, 2006 - v1
Checksum:iF1DD0D0CE8513120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127514 mRNA. Translation: AAI27515.1.
RefSeqiNP_001071137.1. NM_001077669.1.
XP_008763785.1. XM_008765563.1.
XP_008763786.1. XM_008765564.1.
UniGeneiRn.7960.

Genome annotation databases

GeneIDi300051.
KEGGirno:300051.
UCSCiRGD:1306701. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127514 mRNA. Translation: AAI27515.1.
RefSeqiNP_001071137.1. NM_001077669.1.
XP_008763785.1. XM_008765563.1.
XP_008763786.1. XM_008765564.1.
UniGeneiRn.7960.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047376.

Proteomic databases

PaxDbiA0JPN2.
PRIDEiA0JPN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi300051.
KEGGirno:300051.
UCSCiRGD:1306701. rat.

Organism-specific databases

CTDi55630.
RGDi1306701. Slc39a4.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
HOGENOMiHOG000293181.
HOVERGENiHBG062532.
InParanoidiA0JPN2.
KOiK14710.
OMAiFVFRQHS.
OrthoDBiEOG744T95.
PhylomeDBiA0JPN2.
TreeFamiTF318470.

Miscellaneous databases

PROiA0JPN2.

Gene expression databases

GenevisibleiA0JPN2. RN.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.

Entry informationi

Entry nameiS39A4_RAT
AccessioniPrimary (citable) accession number: A0JPN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 12, 2006
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.