ID HLX_RAT Reviewed; 476 AA. AC A0JPN1; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 12-DEC-2006, sequence version 1. DT 24-JAN-2024, entry version 117. DE RecName: Full=H2.0-like homeobox protein; DE AltName: Full=Homeobox protein HLX1; GN Name=Hlx; Synonyms=Hlx1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] {ECO:0000312|EMBL:AAI27514.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung {ECO:0000312|EMBL:AAI27514.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Transcription factor required for TBX21/T-bet-dependent CC maturation of Th1 cells as well as maintenance of Th1-specific gene CC expression. Involved in embryogenesis and hematopoiesis (By CC similarity). {ECO:0000250|UniProtKB:Q61670}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P52950, CC ECO:0000255|PROSITE-ProRule:PRU00108}. CC -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC127513; AAI27514.1; -; mRNA. DR RefSeq; NP_001071142.1; NM_001077674.1. DR AlphaFoldDB; A0JPN1; -. DR SMR; A0JPN1; -. DR STRING; 10116.ENSRNOP00000003155; -. DR PhosphoSitePlus; A0JPN1; -. DR PaxDb; 10116-ENSRNOP00000003155; -. DR Ensembl; ENSRNOT00000003155.6; ENSRNOP00000003155.3; ENSRNOG00000002309.6. DR Ensembl; ENSRNOT00055020523; ENSRNOP00055016524; ENSRNOG00055012080. DR Ensembl; ENSRNOT00060013337; ENSRNOP00060010146; ENSRNOG00060008079. DR Ensembl; ENSRNOT00065028612; ENSRNOP00065022662; ENSRNOG00065017153. DR GeneID; 364069; -. DR KEGG; rno:364069; -. DR UCSC; RGD:1311961; rat. DR AGR; RGD:1311961; -. DR CTD; 3142; -. DR RGD; 1311961; Hlx. DR eggNOG; KOG0488; Eukaryota. DR GeneTree; ENSGT00950000183093; -. DR HOGENOM; CLU_043671_1_0_1; -. DR InParanoid; A0JPN1; -. DR OMA; EPMNEAS; -. DR OrthoDB; 2911948at2759; -. DR PhylomeDB; A0JPN1; -. DR TreeFam; TF350735; -. DR PRO; PR:A0JPN1; -. DR Proteomes; UP000002494; Chromosome 13. DR Bgee; ENSRNOG00000002309; Expressed in esophagus and 19 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD. DR GO; GO:0048513; P:animal organ development; ISO:RGD. DR GO; GO:0008283; P:cell population proliferation; ISO:RGD. DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISO:RGD. DR GO; GO:0048484; P:enteric nervous system development; ISO:RGD. DR GO; GO:0050673; P:epithelial cell proliferation; ISO:RGD. DR GO; GO:0001889; P:liver development; ISO:RGD. DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; ISO:RGD. DR GO; GO:0035265; P:organ growth; ISO:RGD. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD. DR GO; GO:0046622; P:positive regulation of organ growth; ISO:RGD. DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; ISO:RGD. DR GO; GO:0007519; P:skeletal muscle tissue development; ISO:RGD. DR GO; GO:0045063; P:T-helper 1 cell differentiation; ISO:RGD. DR GO; GO:0045064; P:T-helper 2 cell differentiation; ISO:RGD. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR000047; HTH_motif. DR PANTHER; PTHR46808; H2.0-LIKE HOMEOBOX PROTEIN; 1. DR PANTHER; PTHR46808:SF1; H2.0-LIKE HOMEOBOX PROTEIN; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR Genevisible; A0JPN1; RN. PE 2: Evidence at transcript level; KW Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..476 FT /note="H2.0-like homeobox protein" FT /id="PRO_0000311700" FT DNA_BIND 273..332 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 121..170 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 328..401 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 413..476 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 130..146 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 328..372 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 413..467 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 476 AA; 50027 MW; 961BF78D0C817944 CRC64; MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP SEVPAGFPQR LSPLSAAYHQ HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKASAAGA LITASSSASG SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE LLPSHQPSVT SGPQSPEIAQ VPLAGL //