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Protein

H2.0-like homeobox protein

Gene

Hlx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi273 – 33260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
H2.0-like homeobox protein
Alternative name(s):
Homeobox protein HLX1
Gene namesi
Name:Hlx
Synonyms:Hlx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1311961. Hlx.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476H2.0-like homeobox proteinPRO_0000311700Add
BLAST

Proteomic databases

PaxDbiA0JPN1.

Expressioni

Gene expression databases

GenevisibleiA0JPN1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003155.

Structurei

3D structure databases

ProteinModelPortaliA0JPN1.
SMRiA0JPN1. Positions 280-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi91 – 16676Pro-richSequence AnalysisAdd
BLAST
Compositional biasi129 – 1368Poly-GlnSequence Analysis
Compositional biasi362 – 465104Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG331357.
GeneTreeiENSGT00790000122955.
HOGENOMiHOG000112911.
HOVERGENiHBG000457.
InParanoidiA0JPN1.
KOiK09339.
OMAiPMNEASA.
OrthoDBiEOG7FR7H1.
PhylomeDBiA0JPN1.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JPN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL
60 70 80 90 100
HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP
110 120 130 140 150
SEVPAGFPQR LSPLSAAYHQ HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT
160 170 180 190 200
SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL
210 220 230 240 250
TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ
260 270 280 290 300
DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK
310 320 330 340 350
PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG
360 370 380 390 400
GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT
410 420 430 440 450
TVIKASAAGA LITASSSASG SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE
460 470
LLPSHQPSVT SGPQSPEIAQ VPLAGL
Length:476
Mass (Da):50,027
Last modified:December 12, 2006 - v1
Checksum:i961BF78D0C817944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127513 mRNA. Translation: AAI27514.1.
RefSeqiNP_001071142.1. NM_001077674.1.
UniGeneiRn.35243.

Genome annotation databases

EnsembliENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
GeneIDi364069.
KEGGirno:364069.
UCSCiRGD:1311961. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127513 mRNA. Translation: AAI27514.1.
RefSeqiNP_001071142.1. NM_001077674.1.
UniGeneiRn.35243.

3D structure databases

ProteinModelPortaliA0JPN1.
SMRiA0JPN1. Positions 280-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003155.

Proteomic databases

PaxDbiA0JPN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
GeneIDi364069.
KEGGirno:364069.
UCSCiRGD:1311961. rat.

Organism-specific databases

CTDi3142.
RGDi1311961. Hlx.

Phylogenomic databases

eggNOGiNOG331357.
GeneTreeiENSGT00790000122955.
HOGENOMiHOG000112911.
HOVERGENiHBG000457.
InParanoidiA0JPN1.
KOiK09339.
OMAiPMNEASA.
OrthoDBiEOG7FR7H1.
PhylomeDBiA0JPN1.
TreeFamiTF350735.

Miscellaneous databases

NextBioi684784.
PROiA0JPN1.

Gene expression databases

GenevisibleiA0JPN1. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.

Entry informationi

Entry nameiHLX_RAT
AccessioniPrimary (citable) accession number: A0JPN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 12, 2006
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.