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A0JPN1

- HLX_RAT

UniProt

A0JPN1 - HLX_RAT

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Protein

H2.0-like homeobox protein

Gene

Hlx

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi273 – 33260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. embryonic digestive tract morphogenesis Source: Ensembl
  3. enteric nervous system development Source: Ensembl
  4. liver development Source: Ensembl
  5. negative regulation of T-helper 2 cell differentiation Source: Ensembl
  6. positive regulation of cell proliferation Source: Ensembl
  7. positive regulation of organ growth Source: Ensembl
  8. positive regulation of T-helper 1 cell differentiation Source: Ensembl
  9. regulation of transcription, DNA-templated Source: UniProtKB-KW
  10. skeletal muscle tissue development Source: Ensembl
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
H2.0-like homeobox protein
Alternative name(s):
Homeobox protein HLX1
Gene namesi
Name:Hlx
Synonyms:Hlx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1311961. Hlx.

Subcellular locationi

Nucleus By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476H2.0-like homeobox proteinPRO_0000311700Add
BLAST

Proteomic databases

PaxDbiA0JPN1.

Expressioni

Gene expression databases

GenevestigatoriA0JPN1.

Structurei

3D structure databases

ProteinModelPortaliA0JPN1.
SMRiA0JPN1. Positions 280-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi91 – 16676Pro-richSequence AnalysisAdd
BLAST
Compositional biasi129 – 1368Poly-GlnSequence Analysis
Compositional biasi362 – 465104Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG331357.
GeneTreeiENSGT00770000120470.
HOGENOMiHOG000112911.
HOVERGENiHBG000457.
InParanoidiA0JPN1.
KOiK09339.
OMAiAHPHASF.
OrthoDBiEOG7FR7H1.
PhylomeDBiA0JPN1.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JPN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL
60 70 80 90 100
HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP
110 120 130 140 150
SEVPAGFPQR LSPLSAAYHQ HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT
160 170 180 190 200
SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL
210 220 230 240 250
TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ
260 270 280 290 300
DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK
310 320 330 340 350
PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG
360 370 380 390 400
GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT
410 420 430 440 450
TVIKASAAGA LITASSSASG SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE
460 470
LLPSHQPSVT SGPQSPEIAQ VPLAGL
Length:476
Mass (Da):50,027
Last modified:December 12, 2006 - v1
Checksum:i961BF78D0C817944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127513 mRNA. Translation: AAI27514.1.
RefSeqiNP_001071142.1. NM_001077674.1.
UniGeneiRn.35243.

Genome annotation databases

EnsembliENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
GeneIDi364069.
KEGGirno:364069.
UCSCiRGD:1311961. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127513 mRNA. Translation: AAI27514.1 .
RefSeqi NP_001071142.1. NM_001077674.1.
UniGenei Rn.35243.

3D structure databases

ProteinModelPortali A0JPN1.
SMRi A0JPN1. Positions 280-331.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi A0JPN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003155 ; ENSRNOP00000003155 ; ENSRNOG00000002309 .
GeneIDi 364069.
KEGGi rno:364069.
UCSCi RGD:1311961. rat.

Organism-specific databases

CTDi 3142.
RGDi 1311961. Hlx.

Phylogenomic databases

eggNOGi NOG331357.
GeneTreei ENSGT00770000120470.
HOGENOMi HOG000112911.
HOVERGENi HBG000457.
InParanoidi A0JPN1.
KOi K09339.
OMAi AHPHASF.
OrthoDBi EOG7FR7H1.
PhylomeDBi A0JPN1.
TreeFami TF350735.

Miscellaneous databases

NextBioi 684784.
PROi A0JPN1.

Gene expression databases

Genevestigatori A0JPN1.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.

Entry informationi

Entry nameiHLX_RAT
AccessioniPrimary (citable) accession number: A0JPN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 12, 2006
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3