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A0JPN1

- HLX_RAT

UniProt

A0JPN1 - HLX_RAT

Protein

H2.0-like homeobox protein

Gene

Hlx

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi273 – 33260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. embryonic digestive tract morphogenesis Source: Ensembl
    3. enteric nervous system development Source: Ensembl
    4. liver development Source: Ensembl
    5. negative regulation of T-helper 2 cell differentiation Source: Ensembl
    6. positive regulation of cell proliferation Source: Ensembl
    7. positive regulation of organ growth Source: Ensembl
    8. positive regulation of T-helper 1 cell differentiation Source: Ensembl
    9. skeletal muscle tissue development Source: Ensembl
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H2.0-like homeobox protein
    Alternative name(s):
    Homeobox protein HLX1
    Gene namesi
    Name:Hlx
    Synonyms:Hlx1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1311961. Hlx.

    Subcellular locationi

    Nucleus By similarityPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476H2.0-like homeobox proteinPRO_0000311700Add
    BLAST

    Proteomic databases

    PaxDbiA0JPN1.

    Expressioni

    Gene expression databases

    GenevestigatoriA0JPN1.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JPN1.
    SMRiA0JPN1. Positions 280-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi91 – 16676Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi129 – 1368Poly-GlnSequence Analysis
    Compositional biasi362 – 465104Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the H2.0 homeobox family.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG331357.
    GeneTreeiENSGT00730000110534.
    HOGENOMiHOG000112911.
    HOVERGENiHBG000457.
    InParanoidiA0JPN1.
    KOiK09339.
    OMAiAHPHASF.
    OrthoDBiEOG7FR7H1.
    PhylomeDBiA0JPN1.
    TreeFamiTF350735.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JPN1-1 [UniParc]FASTAAdd to Basket

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    MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL    50
    HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP 100
    SEVPAGFPQR LSPLSAAYHQ HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT 150
    SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL 200
    TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ 250
    DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK 300
    PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG 350
    GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT 400
    TVIKASAAGA LITASSSASG SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE 450
    LLPSHQPSVT SGPQSPEIAQ VPLAGL 476
    Length:476
    Mass (Da):50,027
    Last modified:December 12, 2006 - v1
    Checksum:i961BF78D0C817944
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127513 mRNA. Translation: AAI27514.1.
    RefSeqiNP_001071142.1. NM_001077674.1.
    UniGeneiRn.35243.

    Genome annotation databases

    EnsembliENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
    GeneIDi364069.
    KEGGirno:364069.
    UCSCiRGD:1311961. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127513 mRNA. Translation: AAI27514.1 .
    RefSeqi NP_001071142.1. NM_001077674.1.
    UniGenei Rn.35243.

    3D structure databases

    ProteinModelPortali A0JPN1.
    SMRi A0JPN1. Positions 280-331.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A0JPN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003155 ; ENSRNOP00000003155 ; ENSRNOG00000002309 .
    GeneIDi 364069.
    KEGGi rno:364069.
    UCSCi RGD:1311961. rat.

    Organism-specific databases

    CTDi 3142.
    RGDi 1311961. Hlx.

    Phylogenomic databases

    eggNOGi NOG331357.
    GeneTreei ENSGT00730000110534.
    HOGENOMi HOG000112911.
    HOVERGENi HBG000457.
    InParanoidi A0JPN1.
    KOi K09339.
    OMAi AHPHASF.
    OrthoDBi EOG7FR7H1.
    PhylomeDBi A0JPN1.
    TreeFami TF350735.

    Miscellaneous databases

    NextBioi 684784.
    PROi A0JPN1.

    Gene expression databases

    Genevestigatori A0JPN1.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.

    Entry informationi

    Entry nameiHLX_RAT
    AccessioniPrimary (citable) accession number: A0JPN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3