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A0JPN1 (HLX_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H2.0-like homeobox protein
Alternative name(s):
Homeobox protein HLX1
Gene names
Name:Hlx
Synonyms:Hlx1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis By similarity. UniProtKB Q61670

Subcellular location

Nucleus By similarity UniProtKB P52950.

Sequence similarities

Belongs to the H2.0 homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

enteric nervous system development

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

negative regulation of T-helper 2 cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 1 cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of organ growth

Inferred from electronic annotation. Source: Ensembl

skeletal muscle tissue development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476H2.0-like homeobox protein
PRO_0000311700

Regions

DNA binding273 – 33260Homeobox
Compositional bias91 – 16676Pro-rich
Compositional bias129 – 1368Poly-Gln
Compositional bias362 – 465104Ser-rich

Sequences

Sequence LengthMass (Da)Tools
A0JPN1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 961BF78D0C817944

FASTA47650,027
        10         20         30         40         50         60 
MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL HAGVGEPGPA 

        70         80         90        100        110        120 
AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP SEVPAGFPQR LSPLSAAYHQ 

       130        140        150        160        170        180 
HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT SGTRVVPHHS GSAPAPSSKD LKFGIDRILS 

       190        200        210        220        230        240 
AEFDPKVKEG NTLRDLTSLL TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN 

       250        260        270        280        290        300 
PRNSVQHQFQ DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK 

       310        320        330        340        350        360 
PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG GVPAEGEREE 

       370        380        390        400        410        420 
RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKASAAGA LITASSSASG 

       430        440        450        460        470 
SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE LLPSHQPSVT SGPQSPEIAQ VPLAGL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC127513 mRNA. Translation: AAI27514.1.
RefSeqNP_001071142.1. NM_001077674.1.
UniGeneRn.35243.

3D structure databases

ProteinModelPortalA0JPN1.
SMRA0JPN1. Positions 280-331.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA0JPN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
GeneID364069.
KEGGrno:364069.
UCSCRGD:1311961. rat.

Organism-specific databases

CTD3142.
RGD1311961. Hlx.

Phylogenomic databases

eggNOGNOG331357.
GeneTreeENSGT00730000110534.
HOGENOMHOG000112911.
HOVERGENHBG000457.
InParanoidA0JPN1.
KOK09339.
OMAAHPHASF.
OrthoDBEOG7FR7H1.
PhylomeDBA0JPN1.
TreeFamTF350735.

Gene expression databases

GenevestigatorA0JPN1.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio684784.
PROA0JPN1.

Entry information

Entry nameHLX_RAT
AccessionPrimary (citable) accession number: A0JPN1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families