A0JPN1 (HLX_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
H2.0-like homeobox protein

Alternative name(s):
Homeobox protein HLX1

Gene names

Name:	Hlx
Synonyms:	Hlx1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis By similarity. UniProtKB Q61670
Subcellular location	Nucleus By similarity UniProtKB P52950.
Sequence similarities	Belongs to the H2.0 homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW embryonic digestive tract morphogenesis Inferred from electronic annotation. Source: Compara enteric nervous system development Inferred from electronic annotation. Source: Compara liver development Inferred from electronic annotation. Source: Compara negative regulation of T-helper 2 cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of T-helper 1 cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of organ growth Inferred from electronic annotation. Source: Compara skeletal muscle tissue development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	H2.0-like homeobox protein		PRO_0000311700
Regions
	DNA binding	273 – 332	60	Homeobox
	Compositional bias	91 – 166	76	Pro-rich
	Compositional bias	129 – 136	8	Poly-Gln
	Compositional bias	362 – 465	104	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	A0JPN1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 961BF78D0C817944	FASTA	476	50,027
	10 20 30 40 50 60 MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL HAGVGEPGPA 70 80 90 100 110 120 AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP SEVPAGFPQR LSPLSAAYHQ 130 140 150 160 170 180 HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT SGTRVVPHHS GSAPAPSSKD LKFGIDRILS 190 200 210 220 230 240 AEFDPKVKEG NTLRDLTSLL TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN 250 260 270 280 290 300 PRNSVQHQFQ DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK 310 320 330 340 350 360 PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG GVPAEGEREE 370 380 390 400 410 420 RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKASAAGA LITASSSASG 430 440 450 460 470 SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE LLPSHQPSVT SGPQSPEIAQ VPLAGL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC127513 mRNA. Translation: AAI27514.1.
IPI	IPI00194237.
RefSeq	NP_001071142.1. NM_001077674.1.
UniGene	Rn.35243.
3D structure databases
ProteinModelPortal	A0JPN1.
SMR	A0JPN1. Positions 280-331.
ModBase	Search...
Proteomic databases
PaxDb	A0JPN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
GeneID	364069.
KEGG	rno:364069.
UCSC	RGD:1311961. rat.
Organism-specific databases
CTD	3142.
RGD	1311961. Hlx.
Phylogenomic databases
eggNOG	NOG331357.
GeneTree	ENSGT00700000104097.
HOGENOM	HOG000112911.
HOVERGEN	HBG000457.
InParanoid	A0JPN1.
KO	K09339.
OMA	AHPHASF.
OrthoDB	EOG473PRM.
Gene expression databases
Genevestigator	A0JPN1.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	684784.

Entry information

Entry name

HLX_RAT

Accession

Primary (citable) accession number: A0JPN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program