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A0JPL0 (ZN382_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 382
Alternative name(s):
KRAB/zinc finger suppressor protein 1
Short name=KS1
Multiple zinc finger and krueppel-associated box protein KS1
Gene names
Name:Znf382
Synonyms:Zfp382
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a sequence-specific transcriptional repressor. Ref.1 Ref.3

Subunit structure

Interacts with TRIM28; enhances the transcriptional repressor activity. Ref.3

Subcellular location

Nucleus Ref.1 Ref.3.

Tissue specificity

Ubiquitously expressed with higher expression in lung, kidney and testis. Ref.1

Induction

Up-regulated by EGF; delayed early response target for EGF (at protein level). Ref.1

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAD05020.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Zinc finger protein 382
PRO_0000361568

Regions

Domain12 – 8372KRAB
Zinc finger211 – 23323C2H2-type 1
Zinc finger295 – 31723C2H2-type 2
Zinc finger323 – 34523C2H2-type 3
Zinc finger351 – 37323C2H2-type 4
Zinc finger379 – 40123C2H2-type 5
Zinc finger407 – 42923C2H2-type 6
Zinc finger435 – 45723C2H2-type 7
Zinc finger463 – 48523C2H2-type 8
Zinc finger491 – 51323C2H2-type 9
Zinc finger519 – 54123C2H2-type 10
Region1 – 105105Mediates interaction with TRIM28
Region10 – 5142Represses transcription
Region75 – 210136Represses transcription
Region295 – 549255Required for transcriptional repression activity; probably mediates sequence-specific DNA-binding

Experimental info

Mutagenesis16 – 172DV → AA: Loss of transcriptional repressor activity. Loss of interaction with TRIM28. Ref.3

Sequences

Sequence LengthMass (Da)Tools
A0JPL0 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 72B9DA5087E9C177

FASTA54963,563
        10         20         30         40         50         60 
MNCHSVPLQG PVSFKDVTVD FTQEEWQRLD PAQKALYRDV MLENYCHFIS VGFHITKPDM 

        70         80         90        100        110        120 
IRKLEQGEEL WTERMFPSQS YLEDEEVLVK FRDYQDKPPT SIVIINHKKL IKERNNVYEK 

       130        140        150        160        170        180 
TLGNNHIISK TLFEYKSDGK VLKNISDFIS RDINPVMGTL GDSSEWEESV LTSEQEKTHP 

       190        200        210        220        230        240 
VPTLYKQIGR NLSSSLELAQ HQKTQIPEQR FECDECDSSF LMTEVAFPHD RAHRGVRDFN 

       250        260        270        280        290        300 
CSKDEIAFFE KSDLGIHPHN LMEKKCSTYN KYGKLLCRKS VFVMHPRSQV DERPFQCPYC 

       310        320        330        340        350        360 
GNSFRRKSYL IEHQRIHTGE KPYICSQCGK AFRQKTALTL HEKTHTDGKP YLCVDCGKSF 

       370        380        390        400        410        420 
RQKATLTRHH KTHTGEKAYE CTQCGSAFGK KSYLIDHQRT HTGEKPYQCA ECGKAFIQKT 

       430        440        450        460        470        480 
TLTVHQRTHT GEKPYMCSEC GKSFCQKTTL TLHQRIHTGE KPYVCSDCGK SFRQKAILTV 

       490        500        510        520        530        540 
HYRIHTGEKS NGCPQCGKAF SRKSNLIRHQ KTHTGEKPYE CHECGKFFSC KSNLVAHQKT 


HKAETVRFQ 

« Hide

References

« Hide 'large scale' references
[1]"KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1."
Gebelein B., Fernandez-Zapico M., Imoto M., Urrutia R.
J. Clin. Invest. 102:1911-1919(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY EGF, TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein."
Gebelein B., Urrutia R.
Mol. Cell. Biol. 21:928-939(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF 16-ASP-VAL-17, INTERACTION WITH TRIM28, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U56732 mRNA. Translation: AAD05020.1. Sequence problems.
BC127483 mRNA. Translation: AAI27484.1.
RefSeqNP_653350.1. NM_144749.1.
UniGeneRn.11374.

3D structure databases

ProteinModelPortalA0JPL0.
SMRA0JPL0. Positions 349-541.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028187.

Proteomic databases

PaxDbA0JPL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028187; ENSRNOP00000028187; ENSRNOG00000020777.
GeneID246264.
KEGGrno:246264.
UCSCRGD:708385. rat.

Organism-specific databases

CTD233060.
RGD708385. Zfp382.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117469.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidA0JPL0.
KOK09228.
OrthoDBEOG7KSX7Q.
PhylomeDBA0JPL0.
TreeFamTF337898.

Gene expression databases

GenevestigatorA0JPL0.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio623622.
PROA0JPL0.

Entry information

Entry nameZN382_RAT
AccessionPrimary (citable) accession number: A0JPL0
Secondary accession number(s): Q62977
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families