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A0JPL0

- ZN382_RAT

UniProt

A0JPL0 - ZN382_RAT

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Protein

Zinc finger protein 382

Gene

Znf382

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a sequence-specific transcriptional repressor.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: RGD
  2. regulation of cell growth Source: RGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 382
Alternative name(s):
KRAB/zinc finger suppressor protein 1
Short name:
KS1
Multiple zinc finger and krueppel-associated box protein KS1
Gene namesi
Name:Znf382
Synonyms:Zfp382
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi708385. Zfp382.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi16 – 172DV → AA: Loss of transcriptional repressor activity. Loss of interaction with TRIM28. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Zinc finger protein 382PRO_0000361568Add
BLAST

Proteomic databases

PaxDbiA0JPL0.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in lung, kidney and testis.1 Publication

Inductioni

Up-regulated by EGF; delayed early response target for EGF (at protein level).1 Publication

Gene expression databases

GenevestigatoriA0JPL0.

Interactioni

Subunit structurei

Interacts with TRIM28; enhances the transcriptional repressor activity.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028187.

Structurei

3D structure databases

ProteinModelPortaliA0JPL0.
SMRiA0JPL0. Positions 349-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372KRABPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 105105Mediates interaction with TRIM28Add
BLAST
Regioni10 – 5142Represses transcriptionAdd
BLAST
Regioni75 – 210136Represses transcriptionAdd
BLAST
Regioni295 – 549255Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118917.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA0JPL0.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA0JPL0.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JPL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNCHSVPLQG PVSFKDVTVD FTQEEWQRLD PAQKALYRDV MLENYCHFIS
60 70 80 90 100
VGFHITKPDM IRKLEQGEEL WTERMFPSQS YLEDEEVLVK FRDYQDKPPT
110 120 130 140 150
SIVIINHKKL IKERNNVYEK TLGNNHIISK TLFEYKSDGK VLKNISDFIS
160 170 180 190 200
RDINPVMGTL GDSSEWEESV LTSEQEKTHP VPTLYKQIGR NLSSSLELAQ
210 220 230 240 250
HQKTQIPEQR FECDECDSSF LMTEVAFPHD RAHRGVRDFN CSKDEIAFFE
260 270 280 290 300
KSDLGIHPHN LMEKKCSTYN KYGKLLCRKS VFVMHPRSQV DERPFQCPYC
310 320 330 340 350
GNSFRRKSYL IEHQRIHTGE KPYICSQCGK AFRQKTALTL HEKTHTDGKP
360 370 380 390 400
YLCVDCGKSF RQKATLTRHH KTHTGEKAYE CTQCGSAFGK KSYLIDHQRT
410 420 430 440 450
HTGEKPYQCA ECGKAFIQKT TLTVHQRTHT GEKPYMCSEC GKSFCQKTTL
460 470 480 490 500
TLHQRIHTGE KPYVCSDCGK SFRQKAILTV HYRIHTGEKS NGCPQCGKAF
510 520 530 540
SRKSNLIRHQ KTHTGEKPYE CHECGKFFSC KSNLVAHQKT HKAETVRFQ
Length:549
Mass (Da):63,563
Last modified:December 12, 2006 - v1
Checksum:i72B9DA5087E9C177
GO

Sequence cautioni

The sequence AAD05020.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56732 mRNA. Translation: AAD05020.1. Sequence problems.
BC127483 mRNA. Translation: AAI27484.1.
RefSeqiNP_653350.1. NM_144749.1.
UniGeneiRn.11374.

Genome annotation databases

EnsembliENSRNOT00000028187; ENSRNOP00000028187; ENSRNOG00000020777.
GeneIDi246264.
KEGGirno:246264.
UCSCiRGD:708385. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56732 mRNA. Translation: AAD05020.1 . Sequence problems.
BC127483 mRNA. Translation: AAI27484.1 .
RefSeqi NP_653350.1. NM_144749.1.
UniGenei Rn.11374.

3D structure databases

ProteinModelPortali A0JPL0.
SMRi A0JPL0. Positions 349-541.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028187.

Proteomic databases

PaxDbi A0JPL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028187 ; ENSRNOP00000028187 ; ENSRNOG00000020777 .
GeneIDi 246264.
KEGGi rno:246264.
UCSCi RGD:708385. rat.

Organism-specific databases

CTDi 233060.
RGDi 708385. Zfp382.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118917.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi A0JPL0.
KOi K09228.
OrthoDBi EOG7KSX7Q.
PhylomeDBi A0JPL0.
TreeFami TF337898.

Miscellaneous databases

NextBioi 623622.
PROi A0JPL0.

Gene expression databases

Genevestigatori A0JPL0.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1."
    Gebelein B., Fernandez-Zapico M., Imoto M., Urrutia R.
    J. Clin. Invest. 102:1911-1919(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY EGF, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein."
    Gebelein B., Urrutia R.
    Mol. Cell. Biol. 21:928-939(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 16-ASP-VAL-17, INTERACTION WITH TRIM28, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZN382_RAT
AccessioniPrimary (citable) accession number: A0JPL0
Secondary accession number(s): Q62977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3