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A0JPL0

- ZN382_RAT

UniProt

A0JPL0 - ZN382_RAT

Protein

Zinc finger protein 382

Gene

Znf382

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Functions as a sequence-specific transcriptional repressor.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri295 – 31723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri323 – 34523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 42923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 45723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 48523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri491 – 51323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri519 – 54123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: RGD
    2. regulation of cell growth Source: RGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 382
    Alternative name(s):
    KRAB/zinc finger suppressor protein 1
    Short name:
    KS1
    Multiple zinc finger and krueppel-associated box protein KS1
    Gene namesi
    Name:Znf382
    Synonyms:Zfp382
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi708385. Zfp382.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi16 – 172DV → AA: Loss of transcriptional repressor activity. Loss of interaction with TRIM28. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Zinc finger protein 382PRO_0000361568Add
    BLAST

    Proteomic databases

    PaxDbiA0JPL0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with higher expression in lung, kidney and testis.1 Publication

    Inductioni

    Up-regulated by EGF; delayed early response target for EGF (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriA0JPL0.

    Interactioni

    Subunit structurei

    Interacts with TRIM28; enhances the transcriptional repressor activity.1 Publication

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028187.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JPL0.
    SMRiA0JPL0. Positions 349-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 8372KRABPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 105105Mediates interaction with TRIM28Add
    BLAST
    Regioni10 – 5142Represses transcriptionAdd
    BLAST
    Regioni75 – 210136Represses transcriptionAdd
    BLAST
    Regioni295 – 549255Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri295 – 31723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri323 – 34523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 42923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 45723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 48523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri491 – 51323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri519 – 54123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117469.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiA0JPL0.
    KOiK09228.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiA0JPL0.
    TreeFamiTF337898.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JPL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNCHSVPLQG PVSFKDVTVD FTQEEWQRLD PAQKALYRDV MLENYCHFIS    50
    VGFHITKPDM IRKLEQGEEL WTERMFPSQS YLEDEEVLVK FRDYQDKPPT 100
    SIVIINHKKL IKERNNVYEK TLGNNHIISK TLFEYKSDGK VLKNISDFIS 150
    RDINPVMGTL GDSSEWEESV LTSEQEKTHP VPTLYKQIGR NLSSSLELAQ 200
    HQKTQIPEQR FECDECDSSF LMTEVAFPHD RAHRGVRDFN CSKDEIAFFE 250
    KSDLGIHPHN LMEKKCSTYN KYGKLLCRKS VFVMHPRSQV DERPFQCPYC 300
    GNSFRRKSYL IEHQRIHTGE KPYICSQCGK AFRQKTALTL HEKTHTDGKP 350
    YLCVDCGKSF RQKATLTRHH KTHTGEKAYE CTQCGSAFGK KSYLIDHQRT 400
    HTGEKPYQCA ECGKAFIQKT TLTVHQRTHT GEKPYMCSEC GKSFCQKTTL 450
    TLHQRIHTGE KPYVCSDCGK SFRQKAILTV HYRIHTGEKS NGCPQCGKAF 500
    SRKSNLIRHQ KTHTGEKPYE CHECGKFFSC KSNLVAHQKT HKAETVRFQ 549
    Length:549
    Mass (Da):63,563
    Last modified:December 12, 2006 - v1
    Checksum:i72B9DA5087E9C177
    GO

    Sequence cautioni

    The sequence AAD05020.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56732 mRNA. Translation: AAD05020.1. Sequence problems.
    BC127483 mRNA. Translation: AAI27484.1.
    RefSeqiNP_653350.1. NM_144749.1.
    UniGeneiRn.11374.

    Genome annotation databases

    EnsembliENSRNOT00000028187; ENSRNOP00000028187; ENSRNOG00000020777.
    GeneIDi246264.
    KEGGirno:246264.
    UCSCiRGD:708385. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56732 mRNA. Translation: AAD05020.1 . Sequence problems.
    BC127483 mRNA. Translation: AAI27484.1 .
    RefSeqi NP_653350.1. NM_144749.1.
    UniGenei Rn.11374.

    3D structure databases

    ProteinModelPortali A0JPL0.
    SMRi A0JPL0. Positions 349-541.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028187.

    Proteomic databases

    PaxDbi A0JPL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028187 ; ENSRNOP00000028187 ; ENSRNOG00000020777 .
    GeneIDi 246264.
    KEGGi rno:246264.
    UCSCi RGD:708385. rat.

    Organism-specific databases

    CTDi 233060.
    RGDi 708385. Zfp382.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117469.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi A0JPL0.
    KOi K09228.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi A0JPL0.
    TreeFami TF337898.

    Miscellaneous databases

    NextBioi 623622.
    PROi A0JPL0.

    Gene expression databases

    Genevestigatori A0JPL0.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1."
      Gebelein B., Fernandez-Zapico M., Imoto M., Urrutia R.
      J. Clin. Invest. 102:1911-1919(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY EGF, TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein."
      Gebelein B., Urrutia R.
      Mol. Cell. Biol. 21:928-939(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 16-ASP-VAL-17, INTERACTION WITH TRIM28, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiZN382_RAT
    AccessioniPrimary (citable) accession number: A0JPL0
    Secondary accession number(s): Q62977
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3