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Protein

Zinc finger protein 382

Gene

Znf382

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a sequence-specific transcriptional repressor.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • regulation of cell growth Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 382
Alternative name(s):
KRAB/zinc finger suppressor protein 1
Short name:
KS1
Multiple zinc finger and krueppel-associated box protein KS1
Gene namesi
Name:Znf382
Synonyms:Zfp382
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi708385 Zfp382

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16 – 17DV → AA: Loss of transcriptional repressor activity. Loss of interaction with TRIM28. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615681 – 549Zinc finger protein 382Add BLAST549

Proteomic databases

PaxDbiA0JPL0

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in lung, kidney and testis.1 Publication

Inductioni

Up-regulated by EGF; delayed early response target for EGF (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000020777
ExpressionAtlasiA0JPL0 baseline

Interactioni

Subunit structurei

Interacts with TRIM28; enhances the transcriptional repressor activity.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028187

Structurei

3D structure databases

ProteinModelPortaliA0JPL0
SMRiA0JPL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 105Mediates interaction with TRIM281 PublicationAdd BLAST105
Regioni10 – 51Represses transcriptionAdd BLAST42
Regioni75 – 210Represses transcriptionAdd BLAST136
Regioni295 – 549Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingAdd BLAST255

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA0JPL0
KOiK09228
PhylomeDBiA0JPL0
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

A0JPL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCHSVPLQG PVSFKDVTVD FTQEEWQRLD PAQKALYRDV MLENYCHFIS
60 70 80 90 100
VGFHITKPDM IRKLEQGEEL WTERMFPSQS YLEDEEVLVK FRDYQDKPPT
110 120 130 140 150
SIVIINHKKL IKERNNVYEK TLGNNHIISK TLFEYKSDGK VLKNISDFIS
160 170 180 190 200
RDINPVMGTL GDSSEWEESV LTSEQEKTHP VPTLYKQIGR NLSSSLELAQ
210 220 230 240 250
HQKTQIPEQR FECDECDSSF LMTEVAFPHD RAHRGVRDFN CSKDEIAFFE
260 270 280 290 300
KSDLGIHPHN LMEKKCSTYN KYGKLLCRKS VFVMHPRSQV DERPFQCPYC
310 320 330 340 350
GNSFRRKSYL IEHQRIHTGE KPYICSQCGK AFRQKTALTL HEKTHTDGKP
360 370 380 390 400
YLCVDCGKSF RQKATLTRHH KTHTGEKAYE CTQCGSAFGK KSYLIDHQRT
410 420 430 440 450
HTGEKPYQCA ECGKAFIQKT TLTVHQRTHT GEKPYMCSEC GKSFCQKTTL
460 470 480 490 500
TLHQRIHTGE KPYVCSDCGK SFRQKAILTV HYRIHTGEKS NGCPQCGKAF
510 520 530 540
SRKSNLIRHQ KTHTGEKPYE CHECGKFFSC KSNLVAHQKT HKAETVRFQ
Length:549
Mass (Da):63,563
Last modified:December 12, 2006 - v1
Checksum:i72B9DA5087E9C177
GO

Sequence cautioni

The sequence AAD05020 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56732 mRNA Translation: AAD05020.1 Sequence problems.
BC127483 mRNA Translation: AAI27484.1
RefSeqiNP_653350.1, NM_144749.1
UniGeneiRn.11374

Genome annotation databases

EnsembliENSRNOT00000087931; ENSRNOP00000069192; ENSRNOG00000020777
GeneIDi246264
KEGGirno:246264
UCSCiRGD:708385 rat

Similar proteinsi

Entry informationi

Entry nameiZN382_RAT
AccessioniPrimary (citable) accession number: A0JPL0
Secondary accession number(s): Q62977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health