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A0JPK3 (ZFP57_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 57

Short name=Zfp-57
Gene names
Name:Zfp57
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element By similarity.

Subcellular location

Nucleus By similarity. Note: Binds various differentially methylated regions (DMR), including the SNRPN DMR By similarity.

Tissue specificity

Expressed in oligodendrocytes and at lower levels in astrocytes. Ref.3

Domain

The KRAB domain is required for function as transcriptional repressor By similarity.

Zinc fingers 2 and 3 mediate recognition of the target element, ZF2 interacting with the 5' half (TGC) and ZF3 interacting with the 3' half (CGC) By similarity.

Sequence similarities

Contains 5 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Zinc finger protein 57
PRO_0000291966

Regions

Domain17 – 8872KRAB
Zinc finger90 – 11324C2H2-type 1; degenerate
Zinc finger140 – 16223C2H2-type 2
Zinc finger168 – 19023C2H2-type 3
Zinc finger270 – 29223C2H2-type 4
Zinc finger318 – 33720C2H2-type 5; degenerate

Sites

Site1781Crucial for 5-methylcytosine recognition By similarity

Experimental info

Sequence conflict8 – 92Missing in CAE84067. Ref.1
Sequence conflict202 – 2065Missing in CAE84067. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A0JPK3 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 24EB880DD59244C0

FASTA40646,588
        10         20         30         40         50         60 
MAAKKQSKSA KALRTTVRYE DVAVSFTQEE WEYLTSTQKT LYQKVMSETF KNLTFVESKK 

        70         80         90        100        110        120 
KPQEPNPNLK DKDDDKSSTC TGVFKGGPFF FCLTCGKCFK KNTFLFNHQF PVRSRRLAVT 

       130        140        150        160        170        180 
KPQSRKALGH KPQHRGDRPF FCNLCGKTYR DASGLSRHRR AHVGYRPRSC PECGKCFRDQ 

       190        200        210        220        230        240 
SEVNRHLKVH QNKKPVAGSH VKVHQNKPVA SNQKQKGRVP PTTRESPAPA LRHLKVIQGP 

       250        260        270        280        290        300 
VARAKARSSR ASSLEVRSTS VTVARPREKV YCPYCRITFT MRTCLLNHLK IHFRRQPNQH 

       310        320        330        340        350        360 
FCCKESHSSN TLRMQKIYNC PVCDSSFRGK ESLLNHLCSR RPIRLSKCWE ILGHLLGYLR 

       370        380        390        400 
EPLGNIFKVR ESRKRRRKRI SSDSSETEGP SGSDEVMEVD TDSDLS 

« Hide

References

« Hide 'large scale' references
[1]"The genomic sequence and comparative analysis of the rat major histocompatibility complex."
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system."
Alonso M.B., Zoidl G., Taveggia C., Bosse F., Zoidl C., Rahman M., Parmantier E., Dean C.H., Harris B.S., Wrabetz L., Mueller H.W., Jessen K.R., Mirsky R.
J. Biol. Chem. 279:25653-25664(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX883052 Genomic DNA. Translation: CAE84067.1.
BC127468 mRNA. Translation: AAI27469.1.
RefSeqNP_998730.2. NM_213565.4.
XP_006255934.1. XM_006255872.1.
XP_006255935.1. XM_006255873.1.
XP_006255936.1. XM_006255874.1.
UniGeneRn.106247.

3D structure databases

ProteinModelPortalA0JPK3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011704.

Proteomic databases

PRIDEA0JPK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011704; ENSRNOP00000011704; ENSRNOG00000022730.
GeneID361783.
KEGGrno:361783.
UCSCRGD:1302981. rat.

Organism-specific databases

CTD346171.
RGD1302981. Zfp57.

Phylogenomic databases

eggNOGNOG267305.
GeneTreeENSGT00390000002599.
HOGENOMHOG000155778.
HOVERGENHBG108764.
InParanoidA0JPK3.
KOK09228.
OMAEEWEYLT.
OrthoDBEOG79GT6T.
PhylomeDBA0JPK3.
TreeFamTF337947.

Gene expression databases

GenevestigatorA0JPK3.

Family and domain databases

Gene3D3.30.160.60. 2 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio677592.

Entry information

Entry nameZFP57_RAT
AccessionPrimary (citable) accession number: A0JPK3
Secondary accession number(s): Q6MFY0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families