Zinc finger protein 57 - Rattus norvegicus (Rat)

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A0JPK3 (ZFP57_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 52. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger protein 57
Short name=Zfp-57

Gene names

Name:

Zfp57

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells By similarity.
Subcellular location	Nucleus By similarity. Note: Binds various differentially methylated regions (DMR), including the SNRPN DMR By similarity.
Tissue specificity	Expressed in oligodendrocytes and at lower levels in astrocytes. Ref.3
Domain	The KRAB domain is required for function as transcriptional repressor By similarity.
Sequence similarities	Contains 5 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation involved in embryo development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara peripheral nervous system development Inferred from expression pattern Ref.3. Source: RGD regulation of gene expression by genetic imprinting Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear heterochromatin Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 406

406

Zinc finger protein 57

PRO_0000291966

Regions

Domain

17 – 88

KRAB

Zinc finger

90 – 113

C2H2-type 1; degenerate

Zinc finger

140 – 162

C2H2-type 2

Zinc finger

168 – 190

C2H2-type 3

Zinc finger

270 – 292

C2H2-type 4

Zinc finger

318 – 337

C2H2-type 5; degenerate

Experimental info

Sequence conflict

8 – 9

Missing in CAE84067. Ref.1

Sequence conflict

202 – 206

Missing in CAE84067. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

A0JPK3 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 24EB880DD59244C0
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FASTA

406

46,588

        10         20         30         40         50         60 
MAAKKQSKSA KALRTTVRYE DVAVSFTQEE WEYLTSTQKT LYQKVMSETF KNLTFVESKK 

        70         80         90        100        110        120 
KPQEPNPNLK DKDDDKSSTC TGVFKGGPFF FCLTCGKCFK KNTFLFNHQF PVRSRRLAVT 

       130        140        150        160        170        180 
KPQSRKALGH KPQHRGDRPF FCNLCGKTYR DASGLSRHRR AHVGYRPRSC PECGKCFRDQ 

       190        200        210        220        230        240 
SEVNRHLKVH QNKKPVAGSH VKVHQNKPVA SNQKQKGRVP PTTRESPAPA LRHLKVIQGP 

       250        260        270        280        290        300 
VARAKARSSR ASSLEVRSTS VTVARPREKV YCPYCRITFT MRTCLLNHLK IHFRRQPNQH 

       310        320        330        340        350        360 
FCCKESHSSN TLRMQKIYNC PVCDSSFRGK ESLLNHLCSR RPIRLSKCWE ILGHLLGYLR 

       370        380        390        400 
EPLGNIFKVR ESRKRRRKRI SSDSSETEGP SGSDEVMEVD TDSDLS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system." Alonso M.B., Zoidl G., Taveggia C., Bosse F., Zoidl C., Rahman M., Parmantier E., Dean C.H., Harris B.S., Wrabetz L., Mueller H.W., Jessen K.R., Mirsky R. J. Biol. Chem. 279:25653-25664(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX883052 Genomic DNA. Translation: CAE84067.1. BC127468 mRNA. Translation: AAI27469.1.
IPI	IPI00422020.
RefSeq	NP_998730.2. NM_213565.4.
UniGene	Rn.106247.
3D structure databases
ProteinModelPortal	A0JPK3.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000011704.
Proteomic databases
PRIDE	A0JPK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011704; ENSRNOP00000011704; ENSRNOG00000022730.
GeneID	361783.
KEGG	rno:361783.
UCSC	RGD:1302981. rat.
Organism-specific databases
CTD	346171.
RGD	1302981. Zfp57.
Phylogenomic databases
eggNOG	NOG267305.
GeneTree	ENSGT00390000002599.
HOGENOM	HOG000155778.
HOVERGEN	HBG108764.
InParanoid	A0JPK3.
KO	K09228.
OrthoDB	EOG4X6C7Z.
Gene expression databases
ArrayExpress	A0JPK3.
Genevestigator	A0JPK3.
Family and domain databases
Gene3D	3.30.160.60. 2 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	677592.

Entry information

Entry name

ZFP57_RAT

Accession

Primary (citable) accession number: A0JPK3
Secondary accession number(s): Q6MFY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents