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A0JPK3

- ZFP57_RAT

UniProt

A0JPK3 - ZFP57_RAT

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Protein

Zinc finger protein 57

Gene

Zfp57

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei178 – 1781Crucial for 5-methylcytosine recognitionBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri90 – 11324C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 33720C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA methylation involved in embryo development Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. peripheral nervous system development Source: RGD
  4. regulation of gene expression by genetic imprinting Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 57
Short name:
Zfp-57
Gene namesi
Name:Zfp57
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1302981. Zfp57.

Subcellular locationi

Nucleus By similarity
Note: Binds various differentially methylated regions (DMR), including the SNRPN DMR.By similarity

GO - Cellular componenti

  1. nuclear heterochromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Zinc finger protein 57PRO_0000291966Add
BLAST

Proteomic databases

PRIDEiA0JPK3.

Expressioni

Tissue specificityi

Expressed in oligodendrocytes and at lower levels in astrocytes.1 Publication

Gene expression databases

GenevestigatoriA0JPK3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011704.

Structurei

3D structure databases

ProteinModelPortaliA0JPK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8872KRABPROSITE-ProRule annotationAdd
BLAST

Domaini

The KRAB domain is required for function as transcriptional repressor.By similarity
Zinc fingers 2 and 3 mediate recognition of the target element, ZF2 interacting with the 5' half (TGC) and ZF3 interacting with the 3' half (CGC).By similarity

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri90 – 11324C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 33720C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG267305.
GeneTreeiENSGT00390000002599.
HOGENOMiHOG000155778.
HOVERGENiHBG108764.
InParanoidiA0JPK3.
KOiK09228.
OMAiEEWEYLT.
OrthoDBiEOG79GT6T.
PhylomeDBiA0JPK3.
TreeFamiTF337947.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JPK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKKQSKSA KALRTTVRYE DVAVSFTQEE WEYLTSTQKT LYQKVMSETF
60 70 80 90 100
KNLTFVESKK KPQEPNPNLK DKDDDKSSTC TGVFKGGPFF FCLTCGKCFK
110 120 130 140 150
KNTFLFNHQF PVRSRRLAVT KPQSRKALGH KPQHRGDRPF FCNLCGKTYR
160 170 180 190 200
DASGLSRHRR AHVGYRPRSC PECGKCFRDQ SEVNRHLKVH QNKKPVAGSH
210 220 230 240 250
VKVHQNKPVA SNQKQKGRVP PTTRESPAPA LRHLKVIQGP VARAKARSSR
260 270 280 290 300
ASSLEVRSTS VTVARPREKV YCPYCRITFT MRTCLLNHLK IHFRRQPNQH
310 320 330 340 350
FCCKESHSSN TLRMQKIYNC PVCDSSFRGK ESLLNHLCSR RPIRLSKCWE
360 370 380 390 400
ILGHLLGYLR EPLGNIFKVR ESRKRRRKRI SSDSSETEGP SGSDEVMEVD

TDSDLS
Length:406
Mass (Da):46,588
Last modified:December 12, 2006 - v1
Checksum:i24EB880DD59244C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 92Missing in CAE84067. (PubMed:15060004)Curated
Sequence conflicti202 – 2065Missing in CAE84067. (PubMed:15060004)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883052 Genomic DNA. Translation: CAE84067.1.
BC127468 mRNA. Translation: AAI27469.1.
RefSeqiNP_998730.2. NM_213565.4.
XP_008770916.1. XM_008772694.1.
UniGeneiRn.106247.

Genome annotation databases

EnsembliENSRNOT00000011704; ENSRNOP00000011704; ENSRNOG00000022730.
GeneIDi361783.
KEGGirno:361783.
UCSCiRGD:1302981. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883052 Genomic DNA. Translation: CAE84067.1 .
BC127468 mRNA. Translation: AAI27469.1 .
RefSeqi NP_998730.2. NM_213565.4.
XP_008770916.1. XM_008772694.1.
UniGenei Rn.106247.

3D structure databases

ProteinModelPortali A0JPK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011704.

Proteomic databases

PRIDEi A0JPK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011704 ; ENSRNOP00000011704 ; ENSRNOG00000022730 .
GeneIDi 361783.
KEGGi rno:361783.
UCSCi RGD:1302981. rat.

Organism-specific databases

CTDi 346171.
RGDi 1302981. Zfp57.

Phylogenomic databases

eggNOGi NOG267305.
GeneTreei ENSGT00390000002599.
HOGENOMi HOG000155778.
HOVERGENi HBG108764.
InParanoidi A0JPK3.
KOi K09228.
OMAi EEWEYLT.
OrthoDBi EOG79GT6T.
PhylomeDBi A0JPK3.
TreeFami TF337947.

Miscellaneous databases

NextBioi 677592.

Gene expression databases

Genevestigatori A0JPK3.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system."
    Alonso M.B., Zoidl G., Taveggia C., Bosse F., Zoidl C., Rahman M., Parmantier E., Dean C.H., Harris B.S., Wrabetz L., Mueller H.W., Jessen K.R., Mirsky R.
    J. Biol. Chem. 279:25653-25664(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiZFP57_RAT
AccessioniPrimary (citable) accession number: A0JPK3
Secondary accession number(s): Q6MFY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 12, 2006
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3