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A0JPK3

- ZFP57_RAT

UniProt

A0JPK3 - ZFP57_RAT

Protein

Zinc finger protein 57

Gene

Zfp57

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei178 – 1781Crucial for 5-methylcytosine recognitionBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri90 – 11324C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri140 – 16223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri168 – 19023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 33720C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA methylation involved in embryo development Source: UniProtKB
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. peripheral nervous system development Source: RGD
    4. regulation of gene expression by genetic imprinting Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 57
    Short name:
    Zfp-57
    Gene namesi
    Name:Zfp57
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1302981. Zfp57.

    Subcellular locationi

    Nucleus By similarity
    Note: Binds various differentially methylated regions (DMR), including the SNRPN DMR.By similarity

    GO - Cellular componenti

    1. nuclear heterochromatin Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Zinc finger protein 57PRO_0000291966Add
    BLAST

    Proteomic databases

    PRIDEiA0JPK3.

    Expressioni

    Tissue specificityi

    Expressed in oligodendrocytes and at lower levels in astrocytes.1 Publication

    Gene expression databases

    GenevestigatoriA0JPK3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011704.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JPK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 8872KRABPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The KRAB domain is required for function as transcriptional repressor.By similarity
    Zinc fingers 2 and 3 mediate recognition of the target element, ZF2 interacting with the 5' half (TGC) and ZF3 interacting with the 3' half (CGC).By similarity

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri90 – 11324C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri140 – 16223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri168 – 19023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 33720C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG267305.
    GeneTreeiENSGT00390000002599.
    HOGENOMiHOG000155778.
    HOVERGENiHBG108764.
    InParanoidiA0JPK3.
    KOiK09228.
    OMAiEEWEYLT.
    OrthoDBiEOG79GT6T.
    PhylomeDBiA0JPK3.
    TreeFamiTF337947.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JPK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKKQSKSA KALRTTVRYE DVAVSFTQEE WEYLTSTQKT LYQKVMSETF    50
    KNLTFVESKK KPQEPNPNLK DKDDDKSSTC TGVFKGGPFF FCLTCGKCFK 100
    KNTFLFNHQF PVRSRRLAVT KPQSRKALGH KPQHRGDRPF FCNLCGKTYR 150
    DASGLSRHRR AHVGYRPRSC PECGKCFRDQ SEVNRHLKVH QNKKPVAGSH 200
    VKVHQNKPVA SNQKQKGRVP PTTRESPAPA LRHLKVIQGP VARAKARSSR 250
    ASSLEVRSTS VTVARPREKV YCPYCRITFT MRTCLLNHLK IHFRRQPNQH 300
    FCCKESHSSN TLRMQKIYNC PVCDSSFRGK ESLLNHLCSR RPIRLSKCWE 350
    ILGHLLGYLR EPLGNIFKVR ESRKRRRKRI SSDSSETEGP SGSDEVMEVD 400
    TDSDLS 406
    Length:406
    Mass (Da):46,588
    Last modified:December 12, 2006 - v1
    Checksum:i24EB880DD59244C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 92Missing in CAE84067. (PubMed:15060004)Curated
    Sequence conflicti202 – 2065Missing in CAE84067. (PubMed:15060004)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX883052 Genomic DNA. Translation: CAE84067.1.
    BC127468 mRNA. Translation: AAI27469.1.
    RefSeqiNP_998730.2. NM_213565.4.
    XP_006255934.1. XM_006255872.1.
    XP_006255935.1. XM_006255873.1.
    XP_006255936.1. XM_006255874.1.
    UniGeneiRn.106247.

    Genome annotation databases

    EnsembliENSRNOT00000011704; ENSRNOP00000011704; ENSRNOG00000022730.
    GeneIDi361783.
    KEGGirno:361783.
    UCSCiRGD:1302981. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX883052 Genomic DNA. Translation: CAE84067.1 .
    BC127468 mRNA. Translation: AAI27469.1 .
    RefSeqi NP_998730.2. NM_213565.4.
    XP_006255934.1. XM_006255872.1.
    XP_006255935.1. XM_006255873.1.
    XP_006255936.1. XM_006255874.1.
    UniGenei Rn.106247.

    3D structure databases

    ProteinModelPortali A0JPK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011704.

    Proteomic databases

    PRIDEi A0JPK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011704 ; ENSRNOP00000011704 ; ENSRNOG00000022730 .
    GeneIDi 361783.
    KEGGi rno:361783.
    UCSCi RGD:1302981. rat.

    Organism-specific databases

    CTDi 346171.
    RGDi 1302981. Zfp57.

    Phylogenomic databases

    eggNOGi NOG267305.
    GeneTreei ENSGT00390000002599.
    HOGENOMi HOG000155778.
    HOVERGENi HBG108764.
    InParanoidi A0JPK3.
    KOi K09228.
    OMAi EEWEYLT.
    OrthoDBi EOG79GT6T.
    PhylomeDBi A0JPK3.
    TreeFami TF337947.

    Miscellaneous databases

    NextBioi 677592.

    Gene expression databases

    Genevestigatori A0JPK3.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
      Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
      Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system."
      Alonso M.B., Zoidl G., Taveggia C., Bosse F., Zoidl C., Rahman M., Parmantier E., Dean C.H., Harris B.S., Wrabetz L., Mueller H.W., Jessen K.R., Mirsky R.
      J. Biol. Chem. 279:25653-25664(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiZFP57_RAT
    AccessioniPrimary (citable) accession number: A0JPK3
    Secondary accession number(s): Q6MFY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3