A0JPH3 (G251A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Procollagen galactosyltransferase 1-A
EC=2.4.1.50

Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1-A
Glycosyltransferase 25 family member 1-A
Hydroxylysine galactosyltransferase 1-A

Gene names

Name:	colgalt1-a
Synonyms:	glt25d1-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen By similarity.
Catalytic activity	UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	procollagen galactosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 611	587	Procollagen galactosyltransferase 1-A		PRO_0000309539
Regions
	Motif	608 – 611	4	Prevents secretion from ER By similarity
Amino acid modifications
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
	Glycosylation	568	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A0JPH3 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 64632CE3A3ED9987	FASTA	611	71,389
	10 20 30 40 50 60 MSQAGVDRLL RGLQLLLLVL RLSAGYFPEE RWNPESSLRN PTVLIALLAR NSEGSLPEVL 70 80 90 100 110 120 GALDTLHYPK ERISLWVATD HNLDNTTEIL REWLINVQNQ YHHVEWRPQE HPRWFKDEEG 130 140 150 160 170 180 PKHWSHSRYE YIMKLRQAAL TSAREMWADY IFFLDADNLL TNPETLNLLI AENKTVVAPM 190 200 210 220 230 240 LDSRAAYSNF WCGMTTQGYY RRTPAYMPIR RRERRGCFPV PMVHSTFLID LRKEASQQLN 250 260 270 280 290 300 FYPPHADYTW AFDDIIVFAF SCRQADVQMF LCNKEIYGHL PVPLRSHGTL LDEADNFVHT 310 320 330 340 350 360 KLEVMVKGPP LNLSSFVTIP EKVPDKMSFD EVFLINLKHR QDRRERMKRT LYELQIDYKL 370 380 390 400 410 420 VDAVYGKTLN QTQVSELGIK MLPDYKDPYH GRPLTRGEMG CFLSHYNIWK EISERNLAVS 430 440 450 460 470 480 AVFEDDLRFE IYFKRRLQTL LHDLETAKLD WDLIYLGRKR MQVDEPEEPV PGVRNLVVSD 490 500 510 520 530 540 YSYWTLGYLI SLRGAKKLLN AEPLVKMLPV DEFLPVMYDK HPISDYSSHF SPRDLLAFSV 550 560 570 580 590 600 EPLLLYPTHY TGDEGYISDT ETSVLWDNLT EPTDWDRAKS RKTQQQEKLR SEALNSPSLG 610 SPFDNTARDE L

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC127422 mRNA. Translation: AAI27423.1.
RefSeq	NP_001096660.1. NM_001103190.1.
UniGene	Xl.73189.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT25. Glycosyltransferase Family 25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100125229.
KEGG	xla:100125229.
Organism-specific databases
CTD	100125229.
Xenbase	XB-GENE-952958. colgalt1.
Phylogenomic databases
HOVERGEN	HBG058097.
KO	K11703.
Family and domain databases
InterPro	IPR002654. Glyco_trans_25. [Graphical view]
Pfam	PF01755. Glyco_transf_25. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G251A_XENLA

Accession

Primary (citable) accession number: A0JPH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program