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Protein

Procollagen galactosyltransferase 1-A

Gene

colgalt1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.By similarity

Catalytic activityi

UDP-alpha-D-galactose + [procollagen]-(2S,5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen galactosyltransferase 1-A (EC:2.4.1.50By similarity)
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1-A
Glycosyltransferase 25 family member 1-A
Hydroxylysine galactosyltransferase 1-A
Gene namesi
Name:colgalt1-a
Synonyms:glt25d1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-952958. colgalt1.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000030953925 – 611Procollagen galactosyltransferase 1-AAdd BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi608 – 611Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG058097.
KOiK11703.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0JPH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAGVDRLL RGLQLLLLVL RLSAGYFPEE RWNPESSLRN PTVLIALLAR
60 70 80 90 100
NSEGSLPEVL GALDTLHYPK ERISLWVATD HNLDNTTEIL REWLINVQNQ
110 120 130 140 150
YHHVEWRPQE HPRWFKDEEG PKHWSHSRYE YIMKLRQAAL TSAREMWADY
160 170 180 190 200
IFFLDADNLL TNPETLNLLI AENKTVVAPM LDSRAAYSNF WCGMTTQGYY
210 220 230 240 250
RRTPAYMPIR RRERRGCFPV PMVHSTFLID LRKEASQQLN FYPPHADYTW
260 270 280 290 300
AFDDIIVFAF SCRQADVQMF LCNKEIYGHL PVPLRSHGTL LDEADNFVHT
310 320 330 340 350
KLEVMVKGPP LNLSSFVTIP EKVPDKMSFD EVFLINLKHR QDRRERMKRT
360 370 380 390 400
LYELQIDYKL VDAVYGKTLN QTQVSELGIK MLPDYKDPYH GRPLTRGEMG
410 420 430 440 450
CFLSHYNIWK EISERNLAVS AVFEDDLRFE IYFKRRLQTL LHDLETAKLD
460 470 480 490 500
WDLIYLGRKR MQVDEPEEPV PGVRNLVVSD YSYWTLGYLI SLRGAKKLLN
510 520 530 540 550
AEPLVKMLPV DEFLPVMYDK HPISDYSSHF SPRDLLAFSV EPLLLYPTHY
560 570 580 590 600
TGDEGYISDT ETSVLWDNLT EPTDWDRAKS RKTQQQEKLR SEALNSPSLG
610
SPFDNTARDE L
Length:611
Mass (Da):71,389
Last modified:December 12, 2006 - v1
Checksum:i64632CE3A3ED9987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127422 mRNA. Translation: AAI27423.1.
RefSeqiNP_001096660.1. NM_001103190.1.
UniGeneiXl.73189.

Genome annotation databases

GeneIDi100125229.
KEGGixla:100125229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127422 mRNA. Translation: AAI27423.1.
RefSeqiNP_001096660.1. NM_001103190.1.
UniGeneiXl.73189.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100125229.
KEGGixla:100125229.

Organism-specific databases

CTDi79709.
XenbaseiXB-GENE-952958. colgalt1.

Phylogenomic databases

HOVERGENiHBG058097.
KOiK11703.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG251A_XENLA
AccessioniPrimary (citable) accession number: A0JPH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.