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A0JPH3

- G251A_XENLA

UniProt

A0JPH3 - G251A_XENLA

Protein

Procollagen galactosyltransferase 1-A

Gene

colgalt1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.By similarity

    Catalytic activityi

    UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

    GO - Molecular functioni

    1. procollagen galactosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT25. Glycosyltransferase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Procollagen galactosyltransferase 1-A (EC:2.4.1.50)
    Alternative name(s):
    Collagen beta(1-O)galactosyltransferase 1-A
    Glycosyltransferase 25 family member 1-A
    Hydroxylysine galactosyltransferase 1-A
    Gene namesi
    Name:colgalt1-a
    Synonyms:glt25d1-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-952958. colgalt1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 611587Procollagen galactosyltransferase 1-APRO_0000309539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi608 – 6114Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 25 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG058097.
    KOiK11703.

    Family and domain databases

    Gene3Di3.90.550.10. 2 hits.
    InterProiIPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01755. Glyco_transf_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A0JPH3-1 [UniParc]FASTAAdd to Basket

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    MSQAGVDRLL RGLQLLLLVL RLSAGYFPEE RWNPESSLRN PTVLIALLAR    50
    NSEGSLPEVL GALDTLHYPK ERISLWVATD HNLDNTTEIL REWLINVQNQ 100
    YHHVEWRPQE HPRWFKDEEG PKHWSHSRYE YIMKLRQAAL TSAREMWADY 150
    IFFLDADNLL TNPETLNLLI AENKTVVAPM LDSRAAYSNF WCGMTTQGYY 200
    RRTPAYMPIR RRERRGCFPV PMVHSTFLID LRKEASQQLN FYPPHADYTW 250
    AFDDIIVFAF SCRQADVQMF LCNKEIYGHL PVPLRSHGTL LDEADNFVHT 300
    KLEVMVKGPP LNLSSFVTIP EKVPDKMSFD EVFLINLKHR QDRRERMKRT 350
    LYELQIDYKL VDAVYGKTLN QTQVSELGIK MLPDYKDPYH GRPLTRGEMG 400
    CFLSHYNIWK EISERNLAVS AVFEDDLRFE IYFKRRLQTL LHDLETAKLD 450
    WDLIYLGRKR MQVDEPEEPV PGVRNLVVSD YSYWTLGYLI SLRGAKKLLN 500
    AEPLVKMLPV DEFLPVMYDK HPISDYSSHF SPRDLLAFSV EPLLLYPTHY 550
    TGDEGYISDT ETSVLWDNLT EPTDWDRAKS RKTQQQEKLR SEALNSPSLG 600
    SPFDNTARDE L 611
    Length:611
    Mass (Da):71,389
    Last modified:December 12, 2006 - v1
    Checksum:i64632CE3A3ED9987
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127422 mRNA. Translation: AAI27423.1.
    RefSeqiNP_001096660.1. NM_001103190.1.
    UniGeneiXl.73189.

    Genome annotation databases

    GeneIDi100125229.
    KEGGixla:100125229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127422 mRNA. Translation: AAI27423.1 .
    RefSeqi NP_001096660.1. NM_001103190.1.
    UniGenei Xl.73189.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT25. Glycosyltransferase Family 25.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125229.
    KEGGi xla:100125229.

    Organism-specific databases

    CTDi 79709.
    Xenbasei XB-GENE-952958. colgalt1.

    Phylogenomic databases

    HOVERGENi HBG058097.
    KOi K11703.

    Family and domain databases

    Gene3Di 3.90.550.10. 2 hits.
    InterProi IPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01755. Glyco_transf_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiG251A_XENLA
    AccessioniPrimary (citable) accession number: A0JPH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3