Reviewed, UniProtKB/Swiss-Prot A0JPE9 (GLPK5_DANRE)

Names and origin

Protein names

Recommended name:
    Putative glycerol kinase 5
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase

Gene names

Name:	gk5
ORF Names:	zgc:152983

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	Putative glycerol kinase 5		PRO_0000323757
Regions
	Nucleotide binding	414 – 419	6	ATP By similarity
Sites
	Binding site	3	1	Substrate By similarity
	Binding site	73	1	Substrate By similarity
	Binding site	250	1	Substrate By similarity
	Binding site	272	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JPE9-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 650AB68D03349B87	FASTA	510	56,486
	10 20 30 40 50 60 MGTTSIRCHV YDKSASIRGS CSAKVSLLYP QPGWVEIDPD ELWDGFVTVV KGAVQDSGLQ 70 80 90 100 110 120 MCQMESLGIS TQRATFMTWD RNTGKPFHKF ITWQDMRAAE LVRSWNGSCA MKTVHGVMKM 130 140 150 160 170 180 LHFLSRQKRF LAASLVVFTT QHVSLRLVWA LNNIPQLRQA VEDGSCYFGT IDTWLLYKLT 190 200 210 220 230 240 KGLVHATDYS NASATAIFDS YQMCWSGFLC SLLSIPLSIL PKVQDTSHKF GLCDSSIFGV 250 260 270 280 290 300 PIPIMCVMAD QQTAMFGECC FDTGDVKITM GTGTFMDINT GSKPHTSVAG LYPLVGWKIG 310 320 330 340 350 360 ADVVYLAEGN AAGTGAAIKW AQDLELFSDV KETEAIATSV EDSDGVFFVP SFSGLQAPLN 370 380 390 400 410 420 DPKACASFMG LKPSTTKRHL VRAILESIAF RNKQLFDVML RETRIPITKI RADGGVCTND 430 440 450 460 470 480 FIMQLTADLL GRKIARPSHF DMSCLGAAFV AGLGTGYWRN QEELKKLLST DQHFLPRRSK 490 500 510 SEGEKGGLYR GVLQSWEKAL QRSMHWYNQP

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC127390 mRNA. Translation: AAI27391.1.
IPI	IPI00619601.
RefSeq	NP_001071271.1.
UniGene	Dr.105755
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0JPE9.
Genome annotation databases
Ensembl	ENSDART00000091351; ENSDARP00000085784; ENSDARG00000062864; Danio rerio. [Genome view]
GeneID	777765.
KEGG	dre:777765.
Organism-specific databases
CTD	777765.
ZFIN	ZDB-GENE-061110-49. gk5.
Phylogenomic databases
HOVERGEN	A0JPE9.
Enzyme and pathway databases
BRENDA	2.7.1.30. 96826.
Gene expression databases
Bgee	A0JPE9.
Family and domain databases
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK5_DANRE

Accession

Primary (citable) accession number: A0JPE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 12, 2006
Last modified:	October 13, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project