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A0JPB4

- IKZF5_XENTR

UniProt

A0JPB4 - IKZF5_XENTR

Protein

Zinc finger protein Pegasus

Gene

ikzf5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri82 – 10423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 13223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri138 – 16124C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41928C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein Pegasus
    Alternative name(s):
    Ikaros family zinc finger protein 5
    Gene namesi
    Name:ikzf5
    ORF Names:TEgg054g02.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-978531. ikzf5.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Zinc finger protein PegasusPRO_0000299477Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA0JPB4.

    Interactioni

    Subunit structurei

    Probably self-associates.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000021087.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JPB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri82 – 10423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 13223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri138 – 16124C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41928C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG283873.
    GeneTreeiENSGT00550000074392.
    HOGENOMiHOG000095162.
    HOVERGENiHBG108001.
    KOiK09220.
    OrthoDBiEOG73BVCH.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A0JPB4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGAGTDSD    50
    QNGLDHPSVE VSLDESAGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH 100
    IRIHTGEKPH RCHLCPFASA YERHLEAHMR SHTGEKPYKC ELCSFRCSDR 150
    SNLSHHRRRK HKMLPIKGTR PSLGNKKMWG VLQKKVSSLG YTRRTLINLS 200
    PPSMVVHKPD YLSDFAHEIP SIQSEAYESL AKASHSGVLS RDPQELMVDN 250
    PLNQLSTLAG QLSSLPPDTQ NPASPDTGPC PDEKPFMIQQ PPPPACASAV 300
    STSVAQSSSP ASPEGRPTHN HRNCSPMAGP SSERSGRTST PSISNSQPST 350
    PAPALPAQDP QLLHHCQHCD MYFADNILYT IHMGCHGFEN PFQCNICGCK 400
    CKNKYDFACH FARGACCQHA SRCAFRRTDD HVAK 434
    Length:434
    Mass (Da):47,991
    Last modified:December 12, 2006 - v1
    Checksum:i3E57D6F82F4D3B85
    GO
    Isoform 2 (identifier: A0JPB4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         44-44: G → GGTQNHDALSANSPCLALPA
         415-434: ACCQHASRCAFRRTDDHVAK → ARGQHTQH

    Show »
    Length:441
    Mass (Da):48,511
    Checksum:i201FDA7D74CF2AA3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei44 – 441G → GGTQNHDALSANSPCLALPA in isoform 2. 2 PublicationsVSP_027695
    Alternative sequencei415 – 43420ACCQH…DHVAK → ARGQHTQH in isoform 2. 2 PublicationsVSP_027696Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848546 mRNA. Translation: CAJ81303.1.
    BC127339 mRNA. Translation: AAI27340.1.
    RefSeqiNP_001017355.1. NM_001017355.2.
    UniGeneiStr.27622.

    Genome annotation databases

    EnsembliENSXETT00000036317; ENSXETP00000036317; ENSXETG00000009559.
    GeneIDi550109.
    KEGGixtr:550109.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848546 mRNA. Translation: CAJ81303.1 .
    BC127339 mRNA. Translation: AAI27340.1 .
    RefSeqi NP_001017355.1. NM_001017355.2.
    UniGenei Str.27622.

    3D structure databases

    ProteinModelPortali A0JPB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000021087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000036317 ; ENSXETP00000036317 ; ENSXETG00000009559 .
    GeneIDi 550109.
    KEGGi xtr:550109.

    Organism-specific databases

    CTDi 64376.
    Xenbasei XB-GENE-978531. ikzf5.

    Phylogenomic databases

    eggNOGi NOG283873.
    GeneTreei ENSGT00550000074392.
    HOGENOMi HOG000095162.
    HOVERGENi HBG108001.
    KOi K09220.
    OrthoDBi EOG73BVCH.

    Gene expression databases

    Bgeei A0JPB4.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Egg.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: N6.
      Tissue: Oviduct.

    Entry informationi

    Entry nameiIKZF5_XENTR
    AccessioniPrimary (citable) accession number: A0JPB4
    Secondary accession number(s): Q28DX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    'Pegasus' was the winged horse in Greek mythology.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3