A0JPB4 (IKZF5_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein Pegasus

Alternative name(s):
Ikaros family zinc finger protein 5

Gene names

Name:	ikzf5
ORF Names:	TEgg054g02.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor By similarity.
Subunit structure	Probably self-associates By similarity.
Subcellular location	Nucleus Probable.
Miscellaneous	'Pegasus' was the winged horse in Greek mythology.
Sequence similarities	Belongs to the Ikaros C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A0JPB4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0JPB4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: G → GGTQNHDALSANSPCLALPA
     415-434: ACCQHASRCAFRRTDDHVAK → ARGQHTQH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Zinc finger protein Pegasus		PRO_0000299477
Regions
	Zinc finger	82 – 104	23	C2H2-type 1
	Zinc finger	110 – 132	23	C2H2-type 2
	Zinc finger	138 – 161	24	C2H2-type 3
	Zinc finger	364 – 386	23	C2H2-type 4
	Zinc finger	392 – 419	28	C2H2-type 5
Natural variations
	Alternative sequence	44	1	G → GGTQNHDALSANSPCLALPA in isoform 2.		VSP_027695
	Alternative sequence	415 – 434	20	ACCQH…DHVAK → ARGQHTQH in isoform 2.		VSP_027696

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 3E57D6F82F4D3B85	FASTA	434	47,991
	10 20 30 40 50 60 MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGAGTDSD QNGLDHPSVE 70 80 90 100 110 120 VSLDESAGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH IRIHTGEKPH RCHLCPFASA 130 140 150 160 170 180 YERHLEAHMR SHTGEKPYKC ELCSFRCSDR SNLSHHRRRK HKMLPIKGTR PSLGNKKMWG 190 200 210 220 230 240 VLQKKVSSLG YTRRTLINLS PPSMVVHKPD YLSDFAHEIP SIQSEAYESL AKASHSGVLS 250 260 270 280 290 300 RDPQELMVDN PLNQLSTLAG QLSSLPPDTQ NPASPDTGPC PDEKPFMIQQ PPPPACASAV 310 320 330 340 350 360 STSVAQSSSP ASPEGRPTHN HRNCSPMAGP SSERSGRTST PSISNSQPST PAPALPAQDP 370 380 390 400 410 420 QLLHHCQHCD MYFADNILYT IHMGCHGFEN PFQCNICGCK CKNKYDFACH FARGACCQHA 430 SRCAFRRTDD HVAK
	Isoform 2 [UniParc]. Checksum: 201FDA7D74CF2AA3	FASTA	441	48,511
	10 20 30 40 50 60 MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGGTQNHD ALSANSPCLA 70 80 90 100 110 120 LPAAGTDSDQ NGLDHPSVEV SLDESAGMLV DGFERTFDGK LKCRYCNYAS KGTARLIEHI 130 140 150 160 170 180 RIHTGEKPHR CHLCPFASAY ERHLEAHMRS HTGEKPYKCE LCSFRCSDRS NLSHHRRRKH 190 200 210 220 230 240 KMLPIKGTRP SLGNKKMWGV LQKKVSSLGY TRRTLINLSP PSMVVHKPDY LSDFAHEIPS 250 260 270 280 290 300 IQSEAYESLA KASHSGVLSR DPQELMVDNP LNQLSTLAGQ LSSLPPDTQN PASPDTGPCP 310 320 330 340 350 360 DEKPFMIQQP PPPACASAVS TSVAQSSSPA SPEGRPTHNH RNCSPMAGPS SERSGRTSTP 370 380 390 400 410 420 SISNSQPSTP APALPAQDPQ LLHHCQHCDM YFADNILYTI HMGCHGFENP FQCNICGCKC 430 440 KNKYDFACHF ARGARGQHTQ H

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Egg.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: N6. Tissue: Oviduct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848546 mRNA. Translation: CAJ81303.1. BC127339 mRNA. Translation: AAI27340.1.
RefSeq	NP_001017355.1. NM_001017355.2.
UniGene	Str.27622.
3D structure databases
ProteinModelPortal	A0JPB4.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000021087.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000036317; ENSXETP00000036317; ENSXETG00000009559.
GeneID	550109.
KEGG	xtr:550109.
Organism-specific databases
CTD	64376.
Xenbase	XB-GENE-978531. ikzf5.
Phylogenomic databases
eggNOG	NOG283873.
GeneTree	ENSGT00550000074392.
HOGENOM	HOG000095162.
HOVERGEN	HBG108001.
KO	K09220.
Gene expression databases
Bgee	A0JPB4.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IKZF5_XENTR

Accession

Primary (citable) accession number: A0JPB4
Secondary accession number(s): Q28DX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program