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A0JPB4 (IKZF5_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein Pegasus
Alternative name(s):
Ikaros family zinc finger protein 5
Gene names
Name:ikzf5
ORF Names:TEgg054g02.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor By similarity.

Subunit structure

Probably self-associates By similarity.

Subcellular location

Nucleus Probable.

Miscellaneous

'Pegasus' was the winged horse in Greek mythology.

Sequence similarities

Belongs to the Ikaros C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A0JPB4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A0JPB4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: G → GGTQNHDALSANSPCLALPA
     415-434: ACCQHASRCAFRRTDDHVAK → ARGQHTQH

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Zinc finger protein Pegasus
PRO_0000299477

Regions

Zinc finger82 – 10423C2H2-type 1
Zinc finger110 – 13223C2H2-type 2
Zinc finger138 – 16124C2H2-type 3
Zinc finger364 – 38623C2H2-type 4
Zinc finger392 – 41928C2H2-type 5

Natural variations

Alternative sequence441G → GGTQNHDALSANSPCLALPA in isoform 2.
VSP_027695
Alternative sequence415 – 43420ACCQH…DHVAK → ARGQHTQH in isoform 2.
VSP_027696

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 3E57D6F82F4D3B85

FASTA43447,991
        10         20         30         40         50         60 
MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGAGTDSD QNGLDHPSVE 

        70         80         90        100        110        120 
VSLDESAGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH IRIHTGEKPH RCHLCPFASA 

       130        140        150        160        170        180 
YERHLEAHMR SHTGEKPYKC ELCSFRCSDR SNLSHHRRRK HKMLPIKGTR PSLGNKKMWG 

       190        200        210        220        230        240 
VLQKKVSSLG YTRRTLINLS PPSMVVHKPD YLSDFAHEIP SIQSEAYESL AKASHSGVLS 

       250        260        270        280        290        300 
RDPQELMVDN PLNQLSTLAG QLSSLPPDTQ NPASPDTGPC PDEKPFMIQQ PPPPACASAV 

       310        320        330        340        350        360 
STSVAQSSSP ASPEGRPTHN HRNCSPMAGP SSERSGRTST PSISNSQPST PAPALPAQDP 

       370        380        390        400        410        420 
QLLHHCQHCD MYFADNILYT IHMGCHGFEN PFQCNICGCK CKNKYDFACH FARGACCQHA 

       430 
SRCAFRRTDD HVAK 

« Hide

Isoform 2 [UniParc].

Checksum: 201FDA7D74CF2AA3
Show »

FASTA44148,511

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: N6.
Tissue: Oviduct.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR848546 mRNA. Translation: CAJ81303.1.
BC127339 mRNA. Translation: AAI27340.1.
RefSeqNP_001017355.1. NM_001017355.2.
UniGeneStr.27622.

3D structure databases

ProteinModelPortalA0JPB4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000021087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000036317; ENSXETP00000036317; ENSXETG00000009559.
GeneID550109.
KEGGxtr:550109.

Organism-specific databases

CTD64376.
XenbaseXB-GENE-978531. ikzf5.

Phylogenomic databases

eggNOGNOG283873.
GeneTreeENSGT00550000074392.
HOGENOMHOG000095162.
HOVERGENHBG108001.
KOK09220.
OrthoDBEOG73BVCH.

Gene expression databases

BgeeA0JPB4.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIKZF5_XENTR
AccessionPrimary (citable) accession number: A0JPB4
Secondary accession number(s): Q28DX8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families