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A0JPB4

- IKZF5_XENTR

UniProt

A0JPB4 - IKZF5_XENTR

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Protein

Zinc finger protein Pegasus

Gene

ikzf5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri82 – 10423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri110 – 13223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri138 – 16124C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41928C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Pegasus
Alternative name(s):
Ikaros family zinc finger protein 5
Gene namesi
Name:ikzf5
ORF Names:TEgg054g02.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-978531. ikzf5.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Zinc finger protein PegasusPRO_0000299477Add
BLAST

Expressioni

Gene expression databases

BgeeiA0JPB4.
ExpressionAtlasiA0JPB4. baseline.

Interactioni

Subunit structurei

Probably self-associates.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000021087.

Structurei

3D structure databases

ProteinModelPortaliA0JPB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri82 – 10423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri110 – 13223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri138 – 16124C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41928C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG283873.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000095162.
HOVERGENiHBG108001.
InParanoidiA0JPB4.
KOiK09220.
OrthoDBiEOG73BVCH.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0JPB4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGAGTDSD
60 70 80 90 100
QNGLDHPSVE VSLDESAGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH
110 120 130 140 150
IRIHTGEKPH RCHLCPFASA YERHLEAHMR SHTGEKPYKC ELCSFRCSDR
160 170 180 190 200
SNLSHHRRRK HKMLPIKGTR PSLGNKKMWG VLQKKVSSLG YTRRTLINLS
210 220 230 240 250
PPSMVVHKPD YLSDFAHEIP SIQSEAYESL AKASHSGVLS RDPQELMVDN
260 270 280 290 300
PLNQLSTLAG QLSSLPPDTQ NPASPDTGPC PDEKPFMIQQ PPPPACASAV
310 320 330 340 350
STSVAQSSSP ASPEGRPTHN HRNCSPMAGP SSERSGRTST PSISNSQPST
360 370 380 390 400
PAPALPAQDP QLLHHCQHCD MYFADNILYT IHMGCHGFEN PFQCNICGCK
410 420 430
CKNKYDFACH FARGACCQHA SRCAFRRTDD HVAK
Length:434
Mass (Da):47,991
Last modified:December 12, 2006 - v1
Checksum:i3E57D6F82F4D3B85
GO
Isoform 2 (identifier: A0JPB4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: G → GGTQNHDALSANSPCLALPA
     415-434: ACCQHASRCAFRRTDDHVAK → ARGQHTQH

Show »
Length:441
Mass (Da):48,511
Checksum:i201FDA7D74CF2AA3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 441G → GGTQNHDALSANSPCLALPA in isoform 2. 2 PublicationsVSP_027695
Alternative sequencei415 – 43420ACCQH…DHVAK → ARGQHTQH in isoform 2. 2 PublicationsVSP_027696Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848546 mRNA. Translation: CAJ81303.1.
BC127339 mRNA. Translation: AAI27340.1.
RefSeqiNP_001017355.1. NM_001017355.2.
UniGeneiStr.27622.

Genome annotation databases

EnsembliENSXETT00000036317; ENSXETP00000036317; ENSXETG00000009559.
GeneIDi550109.
KEGGixtr:550109.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848546 mRNA. Translation: CAJ81303.1 .
BC127339 mRNA. Translation: AAI27340.1 .
RefSeqi NP_001017355.1. NM_001017355.2.
UniGenei Str.27622.

3D structure databases

ProteinModelPortali A0JPB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000021087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000036317 ; ENSXETP00000036317 ; ENSXETG00000009559 .
GeneIDi 550109.
KEGGi xtr:550109.

Organism-specific databases

CTDi 64376.
Xenbasei XB-GENE-978531. ikzf5.

Phylogenomic databases

eggNOGi NOG283873.
GeneTreei ENSGT00550000074392.
HOGENOMi HOG000095162.
HOVERGENi HBG108001.
InParanoidi A0JPB4.
KOi K09220.
OrthoDBi EOG73BVCH.

Gene expression databases

Bgeei A0JPB4.
ExpressionAtlasi A0JPB4. baseline.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: N6.
    Tissue: Oviduct.

Entry informationi

Entry nameiIKZF5_XENTR
AccessioniPrimary (citable) accession number: A0JPB4
Secondary accession number(s): Q28DX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Pegasus' was the winged horse in Greek mythology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3