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Protein

POTE ankyrin domain family member B3

Gene

POTEB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 3 almost identical copies.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member B3Imported
Gene namesi
Name:POTEB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000278522.4
HGNCiHGNC:51240 POTEB3
neXtProtiNX_A0JP26

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004323981 – 581POTE ankyrin domain family member B3Add BLAST581

Proteomic databases

PRIDEiA0JP26

PTM databases

PhosphoSitePlusiA0JP26

Expressioni

Gene expression databases

BgeeiENSG00000278522
ExpressionAtlasiA0JP26 baseline and differential
GenevisibleiA0JP26 HS

Organism-specific databases

HPAiHPA042822

Interactioni

Protein-protein interaction databases

BioGridi130821, 28 interactors

Structurei

3D structure databases

ProteinModelPortaliA0JP26
SMRiA0JP26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati172 – 201ANK 1Sequence analysisAdd BLAST30
Repeati205 – 234ANK 2Sequence analysisAdd BLAST30
Repeati238 – 267ANK 3Sequence analysisAdd BLAST30
Repeati271 – 300ANK 4Sequence analysisAdd BLAST30
Repeati304 – 333ANK 5Sequence analysisAdd BLAST30
Repeati337 – 366ANK 6Sequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili489 – 577Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the POTE family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
COG0666 LUCA
GeneTreeiENSGT00560000076605
HOVERGENiHBG050513
OMAiMEAWEDY
OrthoDBiEOG091G077A
PhylomeDBiA0JP26

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JP26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKTLRSK MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGTW GDYDDSAFME PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KQKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN TALHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
KSRKPENQQF PDTENEEYHS DEQNDTQKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540 550
IEVAEKEMNS KLSLSHKKEE DLLRENSMLR EEIAMLRLEL DETKHQNQLR
560 570 580
ENKILEEIES VKEKLLKAIQ LNEEALTKTS I
Length:581
Mass (Da):65,710
Last modified:March 4, 2015 - v2
Checksum:i86D1E88F98BD22DF
GO
Isoform 2 (identifier: A0JP26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-381: EQDLKL → GKEAEE
     382-581: Missing.

Show »
Length:381
Mass (Da):42,624
Checksum:i020E81CF0BEE970A
GO
Isoform 3 (identifier: A0JP26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-78: Missing.

Show »
Length:544
Mass (Da):61,705
Checksum:i5FEFC47FC805DA5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti510S → P in AAI27124 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08018130H → D1 PublicationCorresponds to variant dbSNP:rs200845208Ensembl.1
Natural variantiVAR_01991543M → V. Corresponds to variant dbSNP:rs2605913Ensembl.1
Natural variantiVAR_01991988N → D1 PublicationCorresponds to variant dbSNP:rs2458862Ensembl.1
Natural variantiVAR_080182203D → G1 Publication1
Natural variantiVAR_080183286Q → E1 PublicationCorresponds to variant dbSNP:rs2445603Ensembl.1
Natural variantiVAR_019921511K → E1 PublicationCorresponds to variant dbSNP:rs1949282Ensembl.1
Natural variantiVAR_019922535M → K1 PublicationCorresponds to variant dbSNP:rs1828869Ensembl.1
Natural variantiVAR_059119568A → T1 PublicationCorresponds to variant dbSNP:rs1828868Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05938042 – 78Missing in isoform 3. Add BLAST37
Alternative sequenceiVSP_059381376 – 381EQDLKL → GKEAEE in isoform 2. 6
Alternative sequenceiVSP_059382382 – 581Missing in isoform 2. Add BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY465170 mRNA Translation: AAS58869.1
AY465173 mRNA Translation: AAS58872.1
AC060814 Genomic DNA No translation available.
BC066981 mRNA Translation: AAH66981.1
BC127123 mRNA Translation: AAI27124.1
CCDSiCCDS73690.1 [A0JP26-1]
RefSeqiNP_997238.2, NM_207355.3 [A0JP26-1]
XP_011542097.1, XM_011543795.2 [A0JP26-2]
UniGeneiHs.722659
Hs.742365

Genome annotation databases

EnsembliENST00000611217; ENSP00000483103; ENSG00000278522
GeneIDi102724631
KEGGihsa:102724631
UCSCiuc059gqe.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPOTB3_HUMAN
AccessioniPrimary (citable) accession number: A0JP26
Secondary accession number(s): A0A096LPD0
, Q6NXN7, Q6S5H4, Q6S5H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: March 4, 2015
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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