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Protein
Submitted name:

Pik3cb protein

Gene

Pik3cb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Pik3cb proteinImported
Gene namesi
Name:Pik3cbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1922019 Pik3cb

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiA0JNZ1
PRIDEiA0JNZ1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 109PI3K-ABDInterPro annotationAdd BLAST90
Domaini188 – 281PI3K-RBDInterPro annotationAdd BLAST94
Domaini305 – 472C2 PI3K-typeInterPro annotationAdd BLAST168
Domaini500 – 677PIK helicalInterPro annotationAdd BLAST178
Domaini776 – 1026PI3K/PI4KInterPro annotationAdd BLAST251

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1007 – 1027Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
HOVERGENiHBG052721

Family and domain databases

CDDicd05173 PI3Kc_IA_beta, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR037702 PI3Kbeta_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 3 hits
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

A0JNZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAMADNLD IWAVDSQIAS DGAISVDFLL PTGIYIQLEV PREATISYIK
60 70 80 90 100
QMLWKQVHNY PMFNLLMDID SYMFACVNQT AVYEELEDET RRLCDVRPFL
110 120 130 140 150
PVLKLVTRSC DPAEKLDSKI GVLIGKGLHE FDALKDPEVN EFRRKMRKFS
160 170 180 190 200
EAKIQSLVGL SWIDWLKHTY PPEHEPSVLE NLEDKLYGGK LVVAVHFENS
210 220 230 240 250
QDVFSFQVSP NLNPIKINEL AIQKRLTIRG KEDEASPCDY VLQYIRNCVM
260 270 280 290 300
NRTLPHFILV ECCKIKKMYE QEMIAIEAAI NRNSSNLPLP LPPKKTRVIS
310 320 330 340 350
HIWDNNNPFQ ITLVKGNKLN TEETVKVHVR AGLFHGTELL CKTVVSSEIS
360 370 380 390 400
GKNDHIWNEQ LEFDINICDL PRMARLCFAV YAVLDKVKTK KSTKTINPSK
410 420 430 440 450
YQTIRKAGKV HYPVAWVNTM VFDFKGQLRS GDVILHSWSS FPDELEEMLN
460 470 480 490 500
PMGTVQTNPY AENATALHIT FPENKKQPCY YPPFDKIIEK AAELASGDSA
510 520 530 540 550
NVSSRGGKKF LAVLKEILDR DPLSQLCENE MDLIWTLRQD CRENFPQSLP
560 570 580 590 600
KLLLSIKWNK LEDVAQLQAL LQIWPKLPPR EALELLDFNY PDQYVREYAV
610 620 630 640 650
GCLRQMSDEE LSQYLLQLVQ VLKYEPFLDC ALSRFLLERA LDNRRIGQFL
660 670 680 690 700
FWHLRSEVHT PAVSVQFGVI LEAYCRGSVG HMKVLSKQVE ALNKLKTLNS
710 720 730 740 750
LIKLNAVKLS RAKGKEAMHT CLKQSAYREA LSDLQSPLNP CVILSELYVE
760 770 780 790 800
KCKYMDSKMK PLWLVYSSRA FGEDSVGVIF KNGDDLRQDM LTLQMLRLMD
810 820 830 840 850
LLWKEAGLDL RMLPYGCLAT GDRSGLIEVV STSETIADIQ LNSSNVAATA
860 870 880 890 900
AFNKDALLNW LKEYNSGDDL DRAIEEFTLS CAGYCVASYV LGIGDRHSDN
910 920 930 940 950
IMVKKTGQLF HIDFGHILGN FKSKFGIKRE RVPFILTYDF IHVIQQGKTG
960 970 980 990 1000
NTEKFGRFRQ CCEDAYLILR RHGNLFITLF ALMLTAGLPE LTSVKDIQYL
1010 1020 1030 1040
KDSLALGKSE EEALKQFKQK FDEALRESWT TKVNWMAHTV RKDYRS
Length:1,046
Mass (Da):119,637
Last modified:December 12, 2006 - v1
Checksum:i09AED8DD8E1C4356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127073 mRNA Translation: AAI27074.1
UniGeneiMm.213128

Genome annotation databases

UCSCiuc012gyy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA0JNZ1_MOUSE
AccessioniPrimary (citable) accession number: A0JNZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
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Main funding by: National Institutes of Health