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A0JNZ1

- A0JNZ1_MOUSE

UniProt

A0JNZ1 - A0JNZ1_MOUSE

Protein
Submitted name:

Pik3cb protein

Gene

Pik3cb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: MGI
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. insulin receptor substrate binding Source: MGI
    5. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: MGI
    2. embryonic cleavage Source: MGI
    3. homophilic cell adhesion Source: MGI
    4. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    5. phosphatidylinositol-mediated signaling Source: InterPro
    6. platelet activation Source: MGI
    7. regulation of cell-matrix adhesion Source: MGI

    Keywords - Molecular functioni

    KinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pik3cb proteinImported
    Gene namesi
    Name:Pik3cbImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1922019. Pik3cb.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: RefGenome
    2. plasma membrane Source: RefGenome

    Expressioni

    Gene expression databases

    ArrayExpressiA0JNZ1.
    BgeeiA0JNZ1.
    GenevestigatoriA0JNZ1.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JNZ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PIK helical domain.
    Contains PI3K/PI4K domain.SAAS annotation
    Contains PIK helical domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG052721.
    InParanoidiA0JNZ1.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JNZ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPAMADNLD IWAVDSQIAS DGAISVDFLL PTGIYIQLEV PREATISYIK     50
    QMLWKQVHNY PMFNLLMDID SYMFACVNQT AVYEELEDET RRLCDVRPFL 100
    PVLKLVTRSC DPAEKLDSKI GVLIGKGLHE FDALKDPEVN EFRRKMRKFS 150
    EAKIQSLVGL SWIDWLKHTY PPEHEPSVLE NLEDKLYGGK LVVAVHFENS 200
    QDVFSFQVSP NLNPIKINEL AIQKRLTIRG KEDEASPCDY VLQYIRNCVM 250
    NRTLPHFILV ECCKIKKMYE QEMIAIEAAI NRNSSNLPLP LPPKKTRVIS 300
    HIWDNNNPFQ ITLVKGNKLN TEETVKVHVR AGLFHGTELL CKTVVSSEIS 350
    GKNDHIWNEQ LEFDINICDL PRMARLCFAV YAVLDKVKTK KSTKTINPSK 400
    YQTIRKAGKV HYPVAWVNTM VFDFKGQLRS GDVILHSWSS FPDELEEMLN 450
    PMGTVQTNPY AENATALHIT FPENKKQPCY YPPFDKIIEK AAELASGDSA 500
    NVSSRGGKKF LAVLKEILDR DPLSQLCENE MDLIWTLRQD CRENFPQSLP 550
    KLLLSIKWNK LEDVAQLQAL LQIWPKLPPR EALELLDFNY PDQYVREYAV 600
    GCLRQMSDEE LSQYLLQLVQ VLKYEPFLDC ALSRFLLERA LDNRRIGQFL 650
    FWHLRSEVHT PAVSVQFGVI LEAYCRGSVG HMKVLSKQVE ALNKLKTLNS 700
    LIKLNAVKLS RAKGKEAMHT CLKQSAYREA LSDLQSPLNP CVILSELYVE 750
    KCKYMDSKMK PLWLVYSSRA FGEDSVGVIF KNGDDLRQDM LTLQMLRLMD 800
    LLWKEAGLDL RMLPYGCLAT GDRSGLIEVV STSETIADIQ LNSSNVAATA 850
    AFNKDALLNW LKEYNSGDDL DRAIEEFTLS CAGYCVASYV LGIGDRHSDN 900
    IMVKKTGQLF HIDFGHILGN FKSKFGIKRE RVPFILTYDF IHVIQQGKTG 950
    NTEKFGRFRQ CCEDAYLILR RHGNLFITLF ALMLTAGLPE LTSVKDIQYL 1000
    KDSLALGKSE EEALKQFKQK FDEALRESWT TKVNWMAHTV RKDYRS 1046
    Length:1,046
    Mass (Da):119,637
    Last modified:December 12, 2006 - v1
    Checksum:i09AED8DD8E1C4356
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127073 mRNA. Translation: AAI27074.1.
    UniGeneiMm.213128.

    Genome annotation databases

    UCSCiuc012gyy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127073 mRNA. Translation: AAI27074.1 .
    UniGenei Mm.213128.

    3D structure databases

    ProteinModelPortali A0JNZ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc012gyy.1. mouse.

    Organism-specific databases

    MGIi MGI:1922019. Pik3cb.

    Phylogenomic databases

    HOVERGENi HBG052721.
    InParanoidi A0JNZ1.

    Miscellaneous databases

    NextBioi 35542216.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A0JNZ1.
    Bgeei A0JNZ1.
    Genevestigatori A0JNZ1.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.

    Entry informationi

    Entry nameiA0JNZ1_MOUSE
    AccessioniPrimary (citable) accession number: A0JNZ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 12, 2006
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)