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A0JNZ1 (A0JNZ1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pik3cb EMBL AAI27074.1 MGI 1922019
OrganismMus musculus (Mouse) EMBL AAI27074.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1046 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PIK helical domain.

Contains PI3K/PI4K domain. SAAS SAAS015433

Contains PIK helical domain. SAAS SAAS018936

Ontologies

Keywords
   LigandATP-binding SAAS SAAS000008
Nucleotide-binding
   Molecular functionKinase SAAS SAAS015433
Transferase
Gene Ontology (GO)
   Biological_processcellular calcium ion homeostasis

Inferred from mutant phenotype PubMed 15834429. Source: MGI

embryonic cleavage

Inferred from mutant phenotype PubMed 11919689. Source: MGI

homophilic cell adhesion

Inferred from mutant phenotype PubMed 15834429. Source: MGI

phosphatidylinositol-3-phosphate biosynthetic process

Inferred from mutant phenotype PubMed 15834429PubMed 16625210. Source: GOC

phosphatidylinositol-mediated signaling

Inferred from electronic annotation. Source: InterPro

platelet activation

Inferred from mutant phenotype PubMed 15834429. Source: MGI

regulation of cell-matrix adhesion

Inferred from mutant phenotype PubMed 15834429. Source: MGI

   Cellular_componentphosphatidylinositol 3-kinase complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_function1-phosphatidylinositol-3-kinase activity

Inferred from mutant phenotype PubMed 15834429PubMed 16625210. Source: MGI

1-phosphatidylinositol-4-phosphate 3-kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

insulin receptor substrate binding

Inferred from physical interaction PubMed 16625210. Source: MGI

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A0JNZ1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 09AED8DD8E1C4356

FASTA1,046119,637
        10         20         30         40         50         60 
MPPAMADNLD IWAVDSQIAS DGAISVDFLL PTGIYIQLEV PREATISYIK QMLWKQVHNY 

        70         80         90        100        110        120 
PMFNLLMDID SYMFACVNQT AVYEELEDET RRLCDVRPFL PVLKLVTRSC DPAEKLDSKI 

       130        140        150        160        170        180 
GVLIGKGLHE FDALKDPEVN EFRRKMRKFS EAKIQSLVGL SWIDWLKHTY PPEHEPSVLE 

       190        200        210        220        230        240 
NLEDKLYGGK LVVAVHFENS QDVFSFQVSP NLNPIKINEL AIQKRLTIRG KEDEASPCDY 

       250        260        270        280        290        300 
VLQYIRNCVM NRTLPHFILV ECCKIKKMYE QEMIAIEAAI NRNSSNLPLP LPPKKTRVIS 

       310        320        330        340        350        360 
HIWDNNNPFQ ITLVKGNKLN TEETVKVHVR AGLFHGTELL CKTVVSSEIS GKNDHIWNEQ 

       370        380        390        400        410        420 
LEFDINICDL PRMARLCFAV YAVLDKVKTK KSTKTINPSK YQTIRKAGKV HYPVAWVNTM 

       430        440        450        460        470        480 
VFDFKGQLRS GDVILHSWSS FPDELEEMLN PMGTVQTNPY AENATALHIT FPENKKQPCY 

       490        500        510        520        530        540 
YPPFDKIIEK AAELASGDSA NVSSRGGKKF LAVLKEILDR DPLSQLCENE MDLIWTLRQD 

       550        560        570        580        590        600 
CRENFPQSLP KLLLSIKWNK LEDVAQLQAL LQIWPKLPPR EALELLDFNY PDQYVREYAV 

       610        620        630        640        650        660 
GCLRQMSDEE LSQYLLQLVQ VLKYEPFLDC ALSRFLLERA LDNRRIGQFL FWHLRSEVHT 

       670        680        690        700        710        720 
PAVSVQFGVI LEAYCRGSVG HMKVLSKQVE ALNKLKTLNS LIKLNAVKLS RAKGKEAMHT 

       730        740        750        760        770        780 
CLKQSAYREA LSDLQSPLNP CVILSELYVE KCKYMDSKMK PLWLVYSSRA FGEDSVGVIF 

       790        800        810        820        830        840 
KNGDDLRQDM LTLQMLRLMD LLWKEAGLDL RMLPYGCLAT GDRSGLIEVV STSETIADIQ 

       850        860        870        880        890        900 
LNSSNVAATA AFNKDALLNW LKEYNSGDDL DRAIEEFTLS CAGYCVASYV LGIGDRHSDN 

       910        920        930        940        950        960 
IMVKKTGQLF HIDFGHILGN FKSKFGIKRE RVPFILTYDF IHVIQQGKTG NTEKFGRFRQ 

       970        980        990       1000       1010       1020 
CCEDAYLILR RHGNLFITLF ALMLTAGLPE LTSVKDIQYL KDSLALGKSE EEALKQFKQK 

      1030       1040 
FDEALRESWT TKVNWMAHTV RKDYRS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PCR rescued clones EMBL AAI27074.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC127073 mRNA. Translation: AAI27074.1.
UniGeneMm.213128.

3D structure databases

ProteinModelPortalA0JNZ1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc012gyy.1. mouse.

Organism-specific databases

MGIMGI:1922019. Pik3cb.

Phylogenomic databases

HOVERGENHBG052721.
InParanoidA0JNZ1.

Gene expression databases

ArrayExpressA0JNZ1.
BgeeA0JNZ1.
GenevestigatorA0JNZ1.

Family and domain databases

Gene3D1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35542216.
SOURCESearch...

Entry information

Entry nameA0JNZ1_MOUSE
AccessionPrimary (citable) accession number: A0JNZ1
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)