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A0JNZ1

- A0JNZ1_MOUSE

UniProt

A0JNZ1 - A0JNZ1_MOUSE

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Protein
Submitted name:

Pik3cb protein

Gene

Pik3cb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: MGI
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. insulin receptor substrate binding Source: MGI
  5. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

GO - Biological processi

  1. cellular calcium ion homeostasis Source: MGI
  2. embryonic cleavage Source: MGI
  3. homophilic cell adhesion Source: MGI
  4. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  5. phosphatidylinositol-mediated signaling Source: InterPro
  6. platelet activation Source: MGI
  7. regulation of cell-matrix adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Pik3cb proteinImported
Gene namesi
Name:Pik3cbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1922019. Pik3cb.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiA0JNZ1.
ExpressionAtlasiA0JNZ1. baseline and differential.
GenevestigatoriA0JNZ1.

Structurei

3D structure databases

ProteinModelPortaliA0JNZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG052721.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JNZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPAMADNLD IWAVDSQIAS DGAISVDFLL PTGIYIQLEV PREATISYIK
60 70 80 90 100
QMLWKQVHNY PMFNLLMDID SYMFACVNQT AVYEELEDET RRLCDVRPFL
110 120 130 140 150
PVLKLVTRSC DPAEKLDSKI GVLIGKGLHE FDALKDPEVN EFRRKMRKFS
160 170 180 190 200
EAKIQSLVGL SWIDWLKHTY PPEHEPSVLE NLEDKLYGGK LVVAVHFENS
210 220 230 240 250
QDVFSFQVSP NLNPIKINEL AIQKRLTIRG KEDEASPCDY VLQYIRNCVM
260 270 280 290 300
NRTLPHFILV ECCKIKKMYE QEMIAIEAAI NRNSSNLPLP LPPKKTRVIS
310 320 330 340 350
HIWDNNNPFQ ITLVKGNKLN TEETVKVHVR AGLFHGTELL CKTVVSSEIS
360 370 380 390 400
GKNDHIWNEQ LEFDINICDL PRMARLCFAV YAVLDKVKTK KSTKTINPSK
410 420 430 440 450
YQTIRKAGKV HYPVAWVNTM VFDFKGQLRS GDVILHSWSS FPDELEEMLN
460 470 480 490 500
PMGTVQTNPY AENATALHIT FPENKKQPCY YPPFDKIIEK AAELASGDSA
510 520 530 540 550
NVSSRGGKKF LAVLKEILDR DPLSQLCENE MDLIWTLRQD CRENFPQSLP
560 570 580 590 600
KLLLSIKWNK LEDVAQLQAL LQIWPKLPPR EALELLDFNY PDQYVREYAV
610 620 630 640 650
GCLRQMSDEE LSQYLLQLVQ VLKYEPFLDC ALSRFLLERA LDNRRIGQFL
660 670 680 690 700
FWHLRSEVHT PAVSVQFGVI LEAYCRGSVG HMKVLSKQVE ALNKLKTLNS
710 720 730 740 750
LIKLNAVKLS RAKGKEAMHT CLKQSAYREA LSDLQSPLNP CVILSELYVE
760 770 780 790 800
KCKYMDSKMK PLWLVYSSRA FGEDSVGVIF KNGDDLRQDM LTLQMLRLMD
810 820 830 840 850
LLWKEAGLDL RMLPYGCLAT GDRSGLIEVV STSETIADIQ LNSSNVAATA
860 870 880 890 900
AFNKDALLNW LKEYNSGDDL DRAIEEFTLS CAGYCVASYV LGIGDRHSDN
910 920 930 940 950
IMVKKTGQLF HIDFGHILGN FKSKFGIKRE RVPFILTYDF IHVIQQGKTG
960 970 980 990 1000
NTEKFGRFRQ CCEDAYLILR RHGNLFITLF ALMLTAGLPE LTSVKDIQYL
1010 1020 1030 1040
KDSLALGKSE EEALKQFKQK FDEALRESWT TKVNWMAHTV RKDYRS
Length:1,046
Mass (Da):119,637
Last modified:December 12, 2006 - v1
Checksum:i09AED8DD8E1C4356
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC127073 mRNA. Translation: AAI27074.1.
UniGeneiMm.213128.

Genome annotation databases

UCSCiuc012gyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC127073 mRNA. Translation: AAI27074.1 .
UniGenei Mm.213128.

3D structure databases

ProteinModelPortali A0JNZ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc012gyy.1. mouse.

Organism-specific databases

MGIi MGI:1922019. Pik3cb.

Phylogenomic databases

HOVERGENi HBG052721.

Miscellaneous databases

NextBioi 35542216.
SOURCEi Search...

Gene expression databases

Bgeei A0JNZ1.
ExpressionAtlasi A0JNZ1. baseline and differential.
Genevestigatori A0JNZ1.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiA0JNZ1_MOUSE
AccessioniPrimary (citable) accession number: A0JNZ1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)