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Protein

UHRF1-binding protein 1-like

Gene

UHRF1BP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UHRF1-binding protein 1-like
Gene namesi
Name:UHRF1BP1L
Synonyms:KIAA0701
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29102. UHRF1BP1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408577.

Polymorphism and mutation databases

BioMutaiUHRF1BP1L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14641464UHRF1-binding protein 1-likePRO_0000295719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei414 – 4141PhosphoserineCombined sources
Modified residuei418 – 4181PhosphoserineCombined sources
Modified residuei774 – 7741PhosphoserineCombined sources
Modified residuei935 – 9351PhosphoserineBy similarity
Modified residuei1009 – 10091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA0JNW5.
MaxQBiA0JNW5.
PaxDbiA0JNW5.
PeptideAtlasiA0JNW5.
PRIDEiA0JNW5.

PTM databases

iPTMnetiA0JNW5.
PhosphoSiteiA0JNW5.

Expressioni

Gene expression databases

BgeeiA0JNW5.
CleanExiHS_UHRF1BP1L.
ExpressionAtlasiA0JNW5. baseline and differential.
GenevisibleiA0JNW5. HS.

Organism-specific databases

HPAiHPA039671.
HPA040399.

Interactioni

Protein-protein interaction databases

BioGridi116706. 14 interactions.
IntActiA0JNW5. 9 interactions.
MINTiMINT-4716044.
STRINGi9606.ENSP00000279907.

Structurei

3D structure databases

ProteinModelPortaliA0JNW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1418 – 145639Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2955. Eukaryota.
ENOG410XQGP. LUCA.
GeneTreeiENSGT00600000084428.
HOVERGENiHBG061128.
InParanoidiA0JNW5.
OMAiNIQHFLE.
OrthoDBiEOG7J445Z.
PhylomeDBiA0JNW5.
TreeFamiTF314874.

Family and domain databases

InterProiIPR026728. UHRF1BP1-like.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR22774. PTHR22774. 1 hit.
PfamiPF12624. Chorein_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JNW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIIKKQIL KHLSRFTKNL SPDKINLSTL KGEGELKNLE LDEEVLQNML
60 70 80 90 100
DLPTWLAINK VFCNKASIRI PWTKLKTHPI CLSLDKVIME MSTCEEPRSP
110 120 130 140 150
NGPSPIATAS GQSEYGFAEK VVEGISVSVN SIVIRIGAKA FNASFELSQL
160 170 180 190 200
RIYSVNAHWE HGDLRFTRIQ DPQRGEVLTF KEINWQMIRI EADATQSSHL
210 220 230 240 250
EIMCAPVRLI TNQSKIRVTL KRRLKDCNVI ATKLVLILDD LLWVLTDSQL
260 270 280 290 300
KAMVQYAKSL SEAIEKSTEQ RKSMAPEPTQ SSTVVASAQQ VKTTQTSNAP
310 320 330 340 350
DVNDAIVKLF NDFDVKETSH HLVISHLDLH ICDDIHAKEK ESNRRITGGA
360 370 380 390 400
MQLSFTQLTI DYYPYHKAGD SCNHWMYFSD ATKTKNGWAN ELLHEFECNV
410 420 430 440 450
EMLKQAVKDH NVGSPPKSPT HASPQHTQTE KDYPLKGTCR TPSVLSQQSK
460 470 480 490 500
AKLMSSSVVV RLADFNIYQV STAEQCRSSP KSMICCNKKS LYLPQEMSAV
510 520 530 540 550
YIEFTEYYYP DGKDFPIPSP NLYSQLNALQ FTVDERSILW LNQFLLDLKQ
560 570 580 590 600
SLNQFMAVYK LNDNSKSDEH VDVRVDGLML KFVIPSEVKS ECHQDQPRAI
610 620 630 640 650
SIQSSEMIAT NTRHCPNCRH SDLEALFQDF KDCDFFSKTY TSFPKSCDNF
660 670 680 690 700
NLLHPIFQRH AHEQDTKMHE IYKGNITPQL NKNTLKTSAA TDVWAVYFSQ
710 720 730 740 750
FWIDYEGMKS GKGRPISFVD SFPLSIWICQ PTRYAESQKE PQTCNQVSLN
760 770 780 790 800
TSQSESSDLA GRLKRKKLLK EYYSTESEPL TNGGQKPSSS DTFFRFSPSS
810 820 830 840 850
SEADIHLLVH VHKHVSMQIN HYQYLLLLFL HESLILLSEN LRKDVEAVTG
860 870 880 890 900
SPASQTSICI GILLRSAELA LLLHPVDQAN TLKSPVSESV SPVVPDYLPT
910 920 930 940 950
ENGDFLSSKR KQISRDINRI RSVTVNHMSD NRSMSVDLSH IPLKDPLLFK
960 970 980 990 1000
SASDTNLQKG ISFMDYLSDK HLGKISEDES SGLVYKSGSG EIGSETSDKK
1010 1020 1030 1040 1050
DSFYTDSSSI LNYREDSNIL SFDSDGNQNI LSSTLTSKGN ETIESIFKAE
1060 1070 1080 1090 1100
DLLPEAASLS ENLDISKEET PPVRTLKSQS SLSGKPKERC PPNLAPLCVS
1110 1120 1130 1140 1150
YKNMKRSSSQ MSLDTISLDS MILEEQLLES DGSDSHMFLE KGNKKNSTTN
1160 1170 1180 1190 1200
YRGTAESVNA GANLQNYGET SPDAISTNSE GAQENHDDLM SVVVFKITGV
1210 1220 1230 1240 1250
NGEIDIRGED TEICLQVNQV TPDQLGNISL RHYLCNRPVG SDQKAVIHSK
1260 1270 1280 1290 1300
SSPEISLRFE SGPGAVIHSL LAEKNGFLQC HIENFSTEFL TSSLMNIQHF
1310 1320 1330 1340 1350
LEDETVATVM PMKIQVSNTK INLKDDSPRS STVSLEPAPV TVHIDHLVVE
1360 1370 1380 1390 1400
RSDDGSFHIR DSHMLNTGND LKENVKSDSV LLTSGKYDLK KQRSVTQATQ
1410 1420 1430 1440 1450
TSPGVPWPSQ SANFPEFSFD FTREQLMEEN ESLKQELAKA KMALAEAHLE
1460
KDALLHHIKK MTVE
Length:1,464
Mass (Da):164,199
Last modified:July 24, 2007 - v2
Checksum:i5FBED173B50F16B9
GO
Isoform 2 (identifier: A0JNW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-522: IPSPNL → TAFLSR
     523-1464: Missing.

Show »
Length:522
Mass (Da):58,906
Checksum:iC72DFE8E0AF7F960
GO

Sequence cautioni

The sequence AAI27018.1 differs from that shown. Reason: Frameshift at position 1004. Curated
The sequence CAB66755.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2831T → I in AAH14891 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1111 – 11111M → L.
Corresponds to variant rs58214704 [ dbSNP | Ensembl ].
VAR_061719
Natural varianti1147 – 11471S → L.1 Publication
Corresponds to variant rs7296162 [ dbSNP | Ensembl ].
VAR_051467
Natural varianti1175 – 11751I → V.
Corresponds to variant rs17029945 [ dbSNP | Ensembl ].
VAR_051468

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei517 – 5226IPSPNL → TAFLSR in isoform 2. 1 PublicationVSP_027014
Alternative sequencei523 – 1464942Missing in isoform 2. 1 PublicationVSP_027015Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003391 mRNA. Translation: AAH03391.1.
BC014891 mRNA. Translation: AAH14891.1.
BC127017 mRNA. Translation: AAI27018.1. Frameshift.
BC026286 mRNA. Translation: AAH26286.1.
AB014601 mRNA. Translation: BAA31676.2.
AL136821 mRNA. Translation: CAB66755.1. Different initiation.
AL833850 mRNA. Translation: CAD38709.1.
CCDSiCCDS31882.1. [A0JNW5-1]
CCDS31883.1. [A0JNW5-2]
PIRiT00352.
RefSeqiNP_001006948.1. NM_001006947.1. [A0JNW5-2]
NP_055869.1. NM_015054.1. [A0JNW5-1]
UniGeneiHs.620701.

Genome annotation databases

EnsembliENST00000279907; ENSP00000279907; ENSG00000111647. [A0JNW5-1]
ENST00000356828; ENSP00000349285; ENSG00000111647. [A0JNW5-2]
GeneIDi23074.
KEGGihsa:23074.
UCSCiuc001tgp.4. human. [A0JNW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003391 mRNA. Translation: AAH03391.1.
BC014891 mRNA. Translation: AAH14891.1.
BC127017 mRNA. Translation: AAI27018.1. Frameshift.
BC026286 mRNA. Translation: AAH26286.1.
AB014601 mRNA. Translation: BAA31676.2.
AL136821 mRNA. Translation: CAB66755.1. Different initiation.
AL833850 mRNA. Translation: CAD38709.1.
CCDSiCCDS31882.1. [A0JNW5-1]
CCDS31883.1. [A0JNW5-2]
PIRiT00352.
RefSeqiNP_001006948.1. NM_001006947.1. [A0JNW5-2]
NP_055869.1. NM_015054.1. [A0JNW5-1]
UniGeneiHs.620701.

3D structure databases

ProteinModelPortaliA0JNW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116706. 14 interactions.
IntActiA0JNW5. 9 interactions.
MINTiMINT-4716044.
STRINGi9606.ENSP00000279907.

PTM databases

iPTMnetiA0JNW5.
PhosphoSiteiA0JNW5.

Polymorphism and mutation databases

BioMutaiUHRF1BP1L.

Proteomic databases

EPDiA0JNW5.
MaxQBiA0JNW5.
PaxDbiA0JNW5.
PeptideAtlasiA0JNW5.
PRIDEiA0JNW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279907; ENSP00000279907; ENSG00000111647. [A0JNW5-1]
ENST00000356828; ENSP00000349285; ENSG00000111647. [A0JNW5-2]
GeneIDi23074.
KEGGihsa:23074.
UCSCiuc001tgp.4. human. [A0JNW5-1]

Organism-specific databases

CTDi23074.
GeneCardsiUHRF1BP1L.
H-InvDBHIX0010913.
HGNCiHGNC:29102. UHRF1BP1L.
HPAiHPA039671.
HPA040399.
neXtProtiNX_A0JNW5.
PharmGKBiPA162408577.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2955. Eukaryota.
ENOG410XQGP. LUCA.
GeneTreeiENSGT00600000084428.
HOVERGENiHBG061128.
InParanoidiA0JNW5.
OMAiNIQHFLE.
OrthoDBiEOG7J445Z.
PhylomeDBiA0JNW5.
TreeFamiTF314874.

Miscellaneous databases

ChiTaRSiUHRF1BP1L. human.
GenomeRNAii23074.
PROiA0JNW5.

Gene expression databases

BgeeiA0JNW5.
CleanExiHS_UHRF1BP1L.
ExpressionAtlasiA0JNW5. baseline and differential.
GenevisibleiA0JNW5. HS.

Family and domain databases

InterProiIPR026728. UHRF1BP1-like.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR22774. PTHR22774. 1 hit.
PfamiPF12624. Chorein_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-1147.
    Tissue: Placenta and Uterus.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-1464 (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 323-1464 (ISOFORM 1).
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-1464 (ISOFORM 1).
    Tissue: Testis.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414 AND SER-418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUH1BL_HUMAN
AccessioniPrimary (citable) accession number: A0JNW5
Secondary accession number(s): A0PJE5
, O75183, Q8NDL1, Q96C30, Q9BTS5, Q9H0F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.