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Protein

60 kDa lysophospholipase

Gene

Aspg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
L-asparagine + H2O = L-aspartate + NH3.
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47 3474
ReactomeiR-MMU-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa lysophospholipase (EC:3.1.1.5)
Including the following 2 domains:
L-asparaginase (EC:3.5.1.1)
Alternative name(s):
L-asparagine amidohydrolase
Platelet-activating factor acetylhydrolase (EC:3.1.1.47)
Short name:
PAF acetylhydrolase
Gene namesi
Name:Aspg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2144822 Aspg

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241641 – 56460 kDa lysophospholipaseAdd BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei478PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA0JNU3
PaxDbiA0JNU3
PRIDEiA0JNU3

PTM databases

iPTMnetiA0JNU3
PhosphoSitePlusiA0JNU3

Expressioni

Gene expression databases

BgeeiENSMUSG00000037686
CleanExiMM_A530050D06RIK
ExpressionAtlasiA0JNU3 baseline and differential
GenevisibleiA0JNU3 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi222710, 1 interactor
STRINGi10090.ENSMUSP00000078369

Structurei

3D structure databases

ProteinModelPortaliA0JNU3
SMRiA0JNU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 355Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST347
Repeati141 – 170ANK 1Add BLAST30
Repeati396 – 426ANK 2Add BLAST31
Repeati430 – 459ANK 3Add BLAST30
Repeati463 – 492ANK 4Add BLAST30
Repeati530 – 559ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 350AsparaginaseAdd BLAST310
Regioni84 – 86Substrate bindingBy similarity3
Regioni116 – 117Substrate bindingBy similarity2

Sequence similaritiesi

In the N-terminal section; belongs to the asparaginase 1 family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0503 Eukaryota
COG0252 LUCA
GeneTreeiENSGT00390000001610
HOGENOMiHOG000227974
HOVERGENiHBG079531
InParanoidiA0JNU3
KOiK13278
OMAiYELENPI
OrthoDBiEOG091G0JYB
PhylomeDBiA0JNU3
TreeFamiTF315247

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
3.40.50.1170, 1 hit
3.40.50.40, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR006033 AsnASEI
IPR036152 Asp/glu_Ase-like_sf
IPR006034 Asparaginase/glutaminase-like
IPR027475 Asparaginase/glutaminase_AS2
IPR027473 L-asparaginase_C
IPR027474 L-asparaginase_N
IPR037152 L-asparaginase_N_sf
PfamiView protein in Pfam
PF00710 Asparaginase, 1 hit
PRINTSiPR00139 ASNGLNASE
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SM00870 Asparaginase, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF53774 SSF53774, 1 hit
TIGRFAMsiTIGR00519 asnASE_I, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS00917 ASN_GLN_ASE_2, 1 hit
PS51732 ASN_GLN_ASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0JNU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAMGPERR LLAIYTGGTI GMRSEGGVLV PGRGLAAVLK TLHMFHDEEY
60 70 80 90 100
AQAHSLPEDT LVLPPASPDQ RIIYTVLECQ PLFDSSDMTI TEWVQIAQTI
110 120 130 140 150
ERHYAQYQGF VVIHGTDTMA FAASVLSFML ENLQKPVVLT GAQVPIHALW
160 170 180 190 200
SDGRENLLGA LLMAGQYVIP EVCLFFQNQL FRGNRTTKVD ARRFAAFCSP
210 220 230 240 250
NLPPLATVGA DVTINRELVR KACGKSHLVV HSSMEPDVGL LRLYPGIPAS
260 270 280 290 300
LVRTFLQPPL KGVVMETFGS GNGPTKPDLL QELRVAAEQG LIIVNCTHCL
310 320 330 340 350
QGAVTSDYAS GMAMAGAGIV SGFDMTSEAA LAKLSYVLGQ PGLSLNDRKK
360 370 380 390 400
LLAKDLRGEM TLPATDVLLQ DGMLGCRVAW LLSMNGSQEA DTMKDVLLPG
410 420 430 440 450
LALAAAHAGD LDTLQAFVEL DRDLNLKDYS GQTPLHVAAR RGHAAVVTML
460 470 480 490 500
LQRGADVDAR NEDGQSPLLL AVRGRHQSVI GLLRAAGARL SPQELEDVGT
510 520 530 540 550
ELCRLASRGD SEGLRAWWQA GADLGQPDYD GHCALQVAEA AGNADVVALL
560
QSFKDSVCAQ PQPH
Length:564
Mass (Da):60,595
Last modified:December 12, 2006 - v1
Checksum:i986677FD4963A55C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126962 mRNA Translation: AAI26963.1
CCDSiCCDS36567.1
RefSeqiNP_001074638.1, NM_001081169.1
UniGeneiMm.77133

Genome annotation databases

EnsembliENSMUST00000079400; ENSMUSP00000078369; ENSMUSG00000037686
GeneIDi104816
KEGGimmu:104816
UCSCiuc007pek.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLPP60_MOUSE
AccessioniPrimary (citable) accession number: A0JNU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 12, 2006
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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