Reviewed,
UniProtKB/Swiss-Prot A0JNU3 (LPP60_MOUSE)
Last modified
June 16, 2009.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 60 kDa lysophospholipase EC=3.1.1.5 Including the following 2 domains: 1- Recommended name: L-asparaginase EC=3.5.1.1 Alternative name(s): L-asparagine amidohydrolase 2- Recommended name: Platelet-activating factor acetylhydrolase Short name=PAF acetylhydrolase EC=3.1.1.47 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 564 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. |
| Catalytic activity | 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. L-asparagine + H2O = L-aspartate + NH3. 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | In the N-terminal section; belongs to the asparaginase 1 family. Contains 5 ANK repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Domain | ANK repeat Repeat |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 1-alkyl-2-acetylglycerophosphocholine esterase activity Inferred from electronic annotation. Source: EC asparaginase activityInferred from electronic annotation. Source: EC lysophospholipase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 564 | 564 | 60 kDa lysophospholipase | PRO_0000324164 | |||||
Regions | |||||||||
| Repeat | 141 – 170 | 30 | ANK 1 | ||||||
| Repeat | 396 – 426 | 31 | ANK 2 | ||||||
| Repeat | 430 – 459 | 30 | ANK 3 | ||||||
| Repeat | 463 – 492 | 30 | ANK 4 | ||||||
| Repeat | 530 – 559 | 30 | ANK 5 | ||||||
| Region | 41 – 350 | 310 | Asparaginase | ||||||
Sites | |||||||||
| Active site | 19 | 1 | By similarity | ||||||
| Active site | 116 | 1 | By similarity | ||||||
| Active site | 117 | 1 | By similarity | ||||||
| Active site | 187 | 1 | By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 387 | 1 | Phosphoserine Ref.2 | ||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed: 17203969] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, MASS SPECTROMETRY. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| BC126962 mRNA. Translation: AAI26963.1. | |
| IPI | IPI00341423. |
| RefSeq | NP_001074638.1. |
| UniGene | Mm.77133 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | A0JNU3. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000037686. Mus musculus. [Contig view] |
| GeneID | 104816. |
| KEGG | mmu:104816. |
| NMPDR | fig|10090.3.peg.27151. |
Organism-specific databases | |
| MGI | MGI:2144822. A530050D06Rik. |
Phylogenomic databases | |
| HOVERGEN | A0JNU3. |
| OMA | A0JNU3. FVIPEVC. |
Enzyme and pathway databases | |
| BRENDA | 3.1.1.47. 244. 3.1.1.5. 244. 3.5.1.1. 244. |
Gene expression databases | |
| Bgee | A0JNU3. |
| CleanEx | MM_A530050D06RIK. |
Family and domain databases | |
| InterPro | IPR002110. ANK. IPR006033. AsnASEI. IPR006034. Asp/Glutamnse. [Graphical view] |
| PANTHER | PTHR11707. Asp/Glutamnse. 1 hit. |
| Pfam | PF00023. Ank. 4 hits. PF00710. Asparaginase. 1 hit. [Graphical view] |
| PRINTS | PR00139. ASNGLNASE. |
| ProDom | PD003221. Asp/Glutamnse. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00248. ANK. 4 hits. [Graphical view] |
| TIGRFAMs | TIGR00519. asnASE_I. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS00144. ASN_GLN_ASE_1. False negative. PS00917. ASN_GLN_ASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 357306. |
| SOURCE | Search... |
Entry information
| Entry name | LPP60_MOUSE | ||||||||
| Accession | Primary (citable) accession number: A0JNU3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


