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A0JNU3 (LPP60_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
60 kDa lysophospholipase
EC=3.1.1.5

Including the following 2 domains:

  1. L-asparaginase
    EC=3.5.1.1
    Alternative name(s):
    L-asparagine amidohydrolase
  2. Platelet-activating factor acetylhydrolase
    Short name=PAF acetylhydrolase
    EC=3.1.1.47
Gene names
Name:Aspg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

L-asparagine + H2O = L-aspartate + NH3.

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subunit structure

Monomer By similarity.

Sequence similarities

In the N-terminal section; belongs to the asparaginase 1 family.

Contains 5 ANK repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 56456460 kDa lysophospholipase
PRO_0000324164

Regions

Repeat141 – 17030ANK 1
Repeat396 – 42631ANK 2
Repeat430 – 45930ANK 3
Repeat463 – 49230ANK 4
Repeat530 – 55930ANK 5
Region41 – 350310Asparaginase
Region84 – 863Substrate binding By similarity
Region116 – 1172Substrate binding By similarity

Sites

Active site191Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue3871Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
A0JNU3 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 986677FD4963A55C

FASTA56460,595
        10         20         30         40         50         60 
MARAMGPERR LLAIYTGGTI GMRSEGGVLV PGRGLAAVLK TLHMFHDEEY AQAHSLPEDT 

        70         80         90        100        110        120 
LVLPPASPDQ RIIYTVLECQ PLFDSSDMTI TEWVQIAQTI ERHYAQYQGF VVIHGTDTMA 

       130        140        150        160        170        180 
FAASVLSFML ENLQKPVVLT GAQVPIHALW SDGRENLLGA LLMAGQYVIP EVCLFFQNQL 

       190        200        210        220        230        240 
FRGNRTTKVD ARRFAAFCSP NLPPLATVGA DVTINRELVR KACGKSHLVV HSSMEPDVGL 

       250        260        270        280        290        300 
LRLYPGIPAS LVRTFLQPPL KGVVMETFGS GNGPTKPDLL QELRVAAEQG LIIVNCTHCL 

       310        320        330        340        350        360 
QGAVTSDYAS GMAMAGAGIV SGFDMTSEAA LAKLSYVLGQ PGLSLNDRKK LLAKDLRGEM 

       370        380        390        400        410        420 
TLPATDVLLQ DGMLGCRVAW LLSMNGSQEA DTMKDVLLPG LALAAAHAGD LDTLQAFVEL 

       430        440        450        460        470        480 
DRDLNLKDYS GQTPLHVAAR RGHAAVVTML LQRGADVDAR NEDGQSPLLL AVRGRHQSVI 

       490        500        510        520        530        540 
GLLRAAGARL SPQELEDVGT ELCRLASRGD SEGLRAWWQA GADLGQPDYD GHCALQVAEA 

       550        560 
AGNADVVALL QSFKDSVCAQ PQPH

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry."
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.
J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC126962 mRNA. Translation: AAI26963.1.
IPIIPI00341423.
RefSeqNP_001074638.1. NM_001081169.1.
UniGeneMm.77133.

3D structure databases

ProteinModelPortalA0JNU3.
SMRA0JNU3. Positions 15-551.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000078369.

PTM databases

PhosphoSiteA0JNU3.

Proteomic databases

PaxDbA0JNU3.
PRIDEA0JNU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079400; ENSMUSP00000078369; ENSMUSG00000037686.
GeneID104816.
KEGGmmu:104816.
UCSCuc007pek.1. mouse.

Organism-specific databases

CTD374569.
MGIMGI:2144822. Aspg.

Phylogenomic databases

eggNOGCOG0252.
GeneTreeENSGT00390000001610.
HOGENOMHOG000227974.
HOVERGENHBG079531.
InParanoidA0JNU3.
KOK13278.
OMAGTIGMRS.
OrthoDBEOG4RR6H4.

Gene expression databases

BgeeA0JNU3.
CleanExMM_A530050D06RIK.
GenevestigatorA0JNU3.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR006033. AsnASEI.
IPR006034. Asparaginase/glutaminase.
IPR020827. Asparaginase/glutaminase_CS.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
PF00710. Asparaginase. 1 hit.
[Graphical view]
PRINTSPR00139. ASNGLNASE.
SMARTSM00248. ANK. 4 hits.
SM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
SSF53774. Asp/Glutamnse. 1 hit.
TIGRFAMsTIGR00519. asnASE_I. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00144. ASN_GLN_ASE_1. False negative.
PS00917. ASN_GLN_ASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio357306.
SOURCESearch...

Entry information

Entry nameLPP60_MOUSE
AccessionPrimary (citable) accession number: A0JNU3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 12, 2006
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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