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A0JNU3

- LPP60_MOUSE

UniProt

A0JNU3 - LPP60_MOUSE

Protein

60 kDa lysophospholipase

Gene

Aspg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
    L-asparagine + H2O = L-aspartate + NH3.
    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei19 – 191Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC
    2. asparaginase activity Source: UniProtKB-EC
    3. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. asparagine metabolic process Source: Ensembl
    2. lipid catabolic process Source: UniProtKB-KW
    3. phospholipid metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60 kDa lysophospholipase (EC:3.1.1.5)
    Including the following 2 domains:
    L-asparaginase (EC:3.5.1.1)
    Alternative name(s):
    L-asparagine amidohydrolase
    Platelet-activating factor acetylhydrolase (EC:3.1.1.47)
    Short name:
    PAF acetylhydrolase
    Gene namesi
    Name:Aspg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2144822. Aspg.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 56456460 kDa lysophospholipasePRO_0000324164Add
    BLAST

    Proteomic databases

    PaxDbiA0JNU3.
    PRIDEiA0JNU3.

    PTM databases

    PhosphoSiteiA0JNU3.

    Expressioni

    Gene expression databases

    BgeeiA0JNU3.
    CleanExiMM_A530050D06RIK.
    GenevestigatoriA0JNU3.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000078369.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JNU3.
    SMRiA0JNU3. Positions 15-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati141 – 17030ANK 1Add
    BLAST
    Repeati396 – 42631ANK 2Add
    BLAST
    Repeati430 – 45930ANK 3Add
    BLAST
    Repeati463 – 49230ANK 4Add
    BLAST
    Repeati530 – 55930ANK 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 350310AsparaginaseAdd
    BLAST
    Regioni84 – 863Substrate bindingBy similarity
    Regioni116 – 1172Substrate bindingBy similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the asparaginase 1 family.Curated
    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0252.
    GeneTreeiENSGT00390000001610.
    HOGENOMiHOG000227974.
    HOVERGENiHBG079531.
    InParanoidiA0JNU3.
    KOiK13278.
    OMAiIGMRSEL.
    OrthoDBiEOG7WDN22.
    PhylomeDBiA0JNU3.
    TreeFamiTF315247.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.40.50.1170. 1 hit.
    3.40.50.40. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR006033. AsnASEI.
    IPR006034. Asparaginase/glutaminase.
    IPR027475. Asparaginase/glutaminase_AS2.
    IPR027473. L-asparaginase_C.
    IPR027474. L-asparaginase_N.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF00710. Asparaginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001220. L-ASNase_gatD. 1 hit.
    PRINTSiPR00139. ASNGLNASE.
    SMARTiSM00248. ANK. 4 hits.
    SM00870. Asparaginase. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF53774. SSF53774. 1 hit.
    TIGRFAMsiTIGR00519. asnASE_I. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS00917. ASN_GLN_ASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JNU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARAMGPERR LLAIYTGGTI GMRSEGGVLV PGRGLAAVLK TLHMFHDEEY    50
    AQAHSLPEDT LVLPPASPDQ RIIYTVLECQ PLFDSSDMTI TEWVQIAQTI 100
    ERHYAQYQGF VVIHGTDTMA FAASVLSFML ENLQKPVVLT GAQVPIHALW 150
    SDGRENLLGA LLMAGQYVIP EVCLFFQNQL FRGNRTTKVD ARRFAAFCSP 200
    NLPPLATVGA DVTINRELVR KACGKSHLVV HSSMEPDVGL LRLYPGIPAS 250
    LVRTFLQPPL KGVVMETFGS GNGPTKPDLL QELRVAAEQG LIIVNCTHCL 300
    QGAVTSDYAS GMAMAGAGIV SGFDMTSEAA LAKLSYVLGQ PGLSLNDRKK 350
    LLAKDLRGEM TLPATDVLLQ DGMLGCRVAW LLSMNGSQEA DTMKDVLLPG 400
    LALAAAHAGD LDTLQAFVEL DRDLNLKDYS GQTPLHVAAR RGHAAVVTML 450
    LQRGADVDAR NEDGQSPLLL AVRGRHQSVI GLLRAAGARL SPQELEDVGT 500
    ELCRLASRGD SEGLRAWWQA GADLGQPDYD GHCALQVAEA AGNADVVALL 550
    QSFKDSVCAQ PQPH 564
    Length:564
    Mass (Da):60,595
    Last modified:December 12, 2006 - v1
    Checksum:i986677FD4963A55C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126962 mRNA. Translation: AAI26963.1.
    CCDSiCCDS36567.1.
    RefSeqiNP_001074638.1. NM_001081169.1.
    UniGeneiMm.77133.

    Genome annotation databases

    EnsembliENSMUST00000079400; ENSMUSP00000078369; ENSMUSG00000037686.
    GeneIDi104816.
    KEGGimmu:104816.
    UCSCiuc007pek.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126962 mRNA. Translation: AAI26963.1 .
    CCDSi CCDS36567.1.
    RefSeqi NP_001074638.1. NM_001081169.1.
    UniGenei Mm.77133.

    3D structure databases

    ProteinModelPortali A0JNU3.
    SMRi A0JNU3. Positions 15-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000078369.

    PTM databases

    PhosphoSitei A0JNU3.

    Proteomic databases

    PaxDbi A0JNU3.
    PRIDEi A0JNU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079400 ; ENSMUSP00000078369 ; ENSMUSG00000037686 .
    GeneIDi 104816.
    KEGGi mmu:104816.
    UCSCi uc007pek.1. mouse.

    Organism-specific databases

    CTDi 374569.
    MGIi MGI:2144822. Aspg.

    Phylogenomic databases

    eggNOGi COG0252.
    GeneTreei ENSGT00390000001610.
    HOGENOMi HOG000227974.
    HOVERGENi HBG079531.
    InParanoidi A0JNU3.
    KOi K13278.
    OMAi IGMRSEL.
    OrthoDBi EOG7WDN22.
    PhylomeDBi A0JNU3.
    TreeFami TF315247.

    Miscellaneous databases

    NextBioi 357306.
    PROi A0JNU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei A0JNU3.
    CleanExi MM_A530050D06RIK.
    Genevestigatori A0JNU3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.40.50.1170. 1 hit.
    3.40.50.40. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR006033. AsnASEI.
    IPR006034. Asparaginase/glutaminase.
    IPR027475. Asparaginase/glutaminase_AS2.
    IPR027473. L-asparaginase_C.
    IPR027474. L-asparaginase_N.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF00710. Asparaginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001220. L-ASNase_gatD. 1 hit.
    PRINTSi PR00139. ASNGLNASE.
    SMARTi SM00248. ANK. 4 hits.
    SM00870. Asparaginase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF53774. SSF53774. 1 hit.
    TIGRFAMsi TIGR00519. asnASE_I. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS00917. ASN_GLN_ASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiLPP60_MOUSE
    AccessioniPrimary (citable) accession number: A0JNU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3