Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BICD family-like cargo adapter 1

Gene

Bicdl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis.1 Publication

GO - Molecular functioni

  • dynactin binding Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • Golgi to secretory granule transport Source: UniProtKB
  • neuron projection development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
BICD family-like cargo adapter 1
Alternative name(s):
Bicaudal D-related protein 1
Short name:
BICD-related protein 1
Short name:
BICDR-1
Coiled-coil domain-containing protein 64A
Gene namesi
Name:Bicdl1
Synonyms:Bicdr1, Ccdc64
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1922915. Ccdc64.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi512K → M: Abolishes Rab6-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028591 – 577BICD family-like cargo adapter 1Add BLAST577

Proteomic databases

EPDiA0JNT9.
PaxDbiA0JNT9.
PRIDEiA0JNT9.

PTM databases

iPTMnetiA0JNT9.
PhosphoSitePlusiA0JNT9.

Expressioni

Tissue specificityi

Highly expressed during early embryonic development. Predominantly expressed in kidney, undifferentiated neural tissue and developing eye.1 Publication

Developmental stagei

Predominately expressed in early developing neurons before the stage of neurite outgrowth and elongation. Then, expression strongly declines during neuronal development.

Gene expression databases

BgeeiENSMUSG00000041609.
CleanExiMM_CCDC64.
ExpressionAtlasiA0JNT9. baseline and differential.
GenevisibleiA0JNT9. MM.

Interactioni

Subunit structurei

Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KIF1CO438963EBI-7893170,EBI-1644048From a different organism.
Rab6aP352796EBI-7893170,EBI-444674
Rab6bP612942EBI-7893170,EBI-529766

GO - Molecular functioni

  • dynactin binding Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi217656. 8 interactors.
IntActiA0JNT9. 18 interactors.
MINTiMINT-7898742.
STRINGi10090.ENSMUSP00000053547.

Structurei

3D structure databases

ProteinModelPortaliA0JNT9.
SMRiA0JNT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili121 – 379Sequence analysisAdd BLAST259
Coiled coili443 – 528Sequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 96Poly-Pro7

Sequence similaritiesi

Belongs to the BICDR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHTB. Eukaryota.
ENOG410ZH4K. LUCA.
GeneTreeiENSGT00560000077255.
HOGENOMiHOG000015285.
HOVERGENiHBG097778.
InParanoidiA0JNT9.
KOiK16756.
OMAiKHLKERS.
OrthoDBiEOG091G0GHR.
PhylomeDBiA0JNT9.
TreeFamiTF326671.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JNT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFCLGLAG RASAPAEPDS ACCMELPAGA GDAVRSPATA AALVSFPGGP
60 70 80 90 100
GELELALEEE LALLAAGERS SEPGEHPQAE PESPVEGHGP PLPPPPTQDP
110 120 130 140 150
ELLSVIRQKE KDLVLAARLG KALLERNQDM SRQYEQMHKE LTDKLEHLEQ
160 170 180 190 200
EKHELRRRFE NREGEWEGRV SELETDVKQL QDELERQQLH LREADREKTR
210 220 230 240 250
AVQELSEQNQ RLLDQLSRAS EVERQLSMQV HALKEDFREK NSSTNQHIIR
260 270 280 290 300
LESLQAEIKM LSDRKRELEH RLSATLEEND LLQGTVEELQ DRVLILERQG
310 320 330 340 350
HDKDLQLHQS QLELQEVRLS YRQLQGKVEE LTEERSLQSS AATSTSLLSE
360 370 380 390 400
IEQSMEAEEL EQEREQLRLQ LWEAYCQVRY LCSHLRGNDS ADSAVSTDSS
410 420 430 440 450
MDESSETSSA KDVPAGSLRT ALNDLKRLIQ SIVDGVEPTV TLLSVEMTAL
460 470 480 490 500
KEERDRLRVT SEDKEPKEQL QKAIRDRDEA IAKKNAVELE LAKCKMDMMS
510 520 530 540 550
LNSQLLDAIQ QKLNLSQQLE AWQDDMHRVI DRQLMDTHLK EQSRPAAAAF
560 570
PRGHGVGRGQ EPSTADGKRL FSFFRKI
Length:577
Mass (Da):65,287
Last modified:December 12, 2006 - v1
Checksum:iDD6326D93D663D07
GO
Isoform 2 (identifier: A0JNT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-227: Missing.
     307-577: LHQSQLELQE...KRLFSFFRKI → ESQVHASGSV...KGHSAPYRSV

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,714
Checksum:i98C6D2B70EEB3BBC
GO
Isoform 3 (identifier: A0JNT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-257: NSSTNQHIIRLESLQAE → MLSQLNSTPSCGSPSFQ
     440-509: VTLLSVEMTA...SLNSQLLDAI → STRRMDDDSL...RGLYLMRPPV
     510-577: Missing.

Note: No experimental confirmation available.
Show »
Length:269
Mass (Da):30,608
Checksum:i3CA05BD7391CBD92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124L → S in AAH24804 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0279701 – 240Missing in isoform 3. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_0279711 – 227Missing in isoform 2. 1 PublicationAdd BLAST227
Alternative sequenceiVSP_027972241 – 257NSSTN…SLQAE → MLSQLNSTPSCGSPSFQ in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_027973307 – 577LHQSQ…FFRKI → ESQVHASGSVSAKPRKILGF LILSKEISCQSKGHSAPYRS V in isoform 2. 1 PublicationAdd BLAST271
Alternative sequenceiVSP_027974440 – 509VTLLS…LLDAI → STRRMDDDSLEEQIRQTSED SRALRELMEGERGKLRQSLE ELQQLHSQVSTPVSQCRECA RGLYLMRPPV in isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_027975510 – 577Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036757 mRNA. Translation: BAC29565.1.
AK041990 mRNA. Translation: BAC31124.1.
BC024804 mRNA. Translation: AAH24804.1.
BC126948 mRNA. Translation: AAI26949.1.
CCDSiCCDS39230.1. [A0JNT9-1]
RefSeqiNP_001074277.1. NM_001080808.1. [A0JNT9-1]
UniGeneiMm.233914.

Genome annotation databases

EnsembliENSMUST00000055408; ENSMUSP00000053547; ENSMUSG00000041609. [A0JNT9-1]
GeneIDi75665.
KEGGimmu:75665.
UCSCiuc008zel.1. mouse. [A0JNT9-1]
uc008zem.1. mouse. [A0JNT9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036757 mRNA. Translation: BAC29565.1.
AK041990 mRNA. Translation: BAC31124.1.
BC024804 mRNA. Translation: AAH24804.1.
BC126948 mRNA. Translation: AAI26949.1.
CCDSiCCDS39230.1. [A0JNT9-1]
RefSeqiNP_001074277.1. NM_001080808.1. [A0JNT9-1]
UniGeneiMm.233914.

3D structure databases

ProteinModelPortaliA0JNT9.
SMRiA0JNT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217656. 8 interactors.
IntActiA0JNT9. 18 interactors.
MINTiMINT-7898742.
STRINGi10090.ENSMUSP00000053547.

PTM databases

iPTMnetiA0JNT9.
PhosphoSitePlusiA0JNT9.

Proteomic databases

EPDiA0JNT9.
PaxDbiA0JNT9.
PRIDEiA0JNT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055408; ENSMUSP00000053547; ENSMUSG00000041609. [A0JNT9-1]
GeneIDi75665.
KEGGimmu:75665.
UCSCiuc008zel.1. mouse. [A0JNT9-1]
uc008zem.1. mouse. [A0JNT9-3]

Organism-specific databases

CTDi75665.
MGIiMGI:1922915. Ccdc64.

Phylogenomic databases

eggNOGiENOG410IHTB. Eukaryota.
ENOG410ZH4K. LUCA.
GeneTreeiENSGT00560000077255.
HOGENOMiHOG000015285.
HOVERGENiHBG097778.
InParanoidiA0JNT9.
KOiK16756.
OMAiKHLKERS.
OrthoDBiEOG091G0GHR.
PhylomeDBiA0JNT9.
TreeFamiTF326671.

Miscellaneous databases

PROiA0JNT9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041609.
CleanExiMM_CCDC64.
ExpressionAtlasiA0JNT9. baseline and differential.
GenevisibleiA0JNT9. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiBICL1_MOUSE
AccessioniPrimary (citable) accession number: A0JNT9
Secondary accession number(s): Q8C9J5, Q8CB56, Q8R1D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.